C-It-Loci: A knowledge database for tissue-enriched loci.

Institute of Cardiovascular Regeneration, Goethe-University Frankfurt am Main

Transcript Info
Description: growth factor receptor bound protein 2
Transcript Accession Transcript Name Contained in Gene Tax ID Strand Position Biotype
ENSMUST00000135065 Grb2-005 ENSMUSG00000059923 10090 - 11:115649857-115699928 protein_coding

Expression Patterns

Heat Map
Numeric Values
Transcript'; BrainOvaryPlacentaTestisENSMUST00000135065
Transcript ID Brain Ovary Placenta Testis
ENSMUST00000135065 215.669±0.00 134.341±0.00 310.897±218.08 13.364±0.00

Conserved Regions

Region IDSub-RegionRegion TypePosition
CIL_0008PW CIL_0008PW_0002 VISTA 11:115369788-115971497
CIL_00021R CIL_00021R_0002 CGP 11:115614178-115708597
CIL_0007J0 CIL_0007J0_0002 CGP 11:115644045-115799366

Gene Ontology

GO IDEvidence TypeGO Description
GO:0005070 IDA SH3/SH2 adaptor activity
GO:0005515 IPI protein binding
GO:0005737 IDA cytoplasm
GO:0005886 IDA plasma membrane
GO:0005911 IDA cell-cell junction
GO:0007265 TAS Ras protein signal transduction
GO:0009967 IDA positive regulation of signal transduction
GO:0012506 IDA vesicle membrane
GO:0016020 IDA membrane
GO:0019904 IPI protein domain specific binding
GO:0030154 IMP cell differentiation
GO:0030838 IGI positive regulation of actin filament polymerization
GO:0043408 IGI regulation of MAPK cascade
GO:0048646 IMP anatomical structure formation involved in morphogenesis
GO:0060670 IMP branching involved in labyrinthine layer morphogenesis

Homologs

ENSEMBL Accession Gene Name Biotype Species E-Value Bit Score
ENST00000316615 GRB2-201 protein_coding Homo_sapiens 0 381
ENST00000316804 GRB2-001 protein_coding Homo_sapiens 0 446
ENST00000392562 GRB2-002 protein_coding Homo_sapiens 0 444
ENST00000392563 GRB2-004 protein_coding Homo_sapiens 0 309
ENST00000392564 GRB2-003 protein_coding Homo_sapiens 0 448
ENST00000462266 GRB2-005 processed_transcript Homo_sapiens 0.0000000004 69
ENST00000577711 GRB2-006 retained_intron Homo_sapiens 0 250
ENST00000578961 GRB2-008 protein_coding Homo_sapiens 0 448
ENST00000582582 GRB2-007 protein_coding Homo_sapiens 0 444
ENST00000583912 GRB2-010 processed_transcript Homo_sapiens 0 250

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