C-It-Loci: A knowledge database for tissue-enriched loci.

Institute of Cardiovascular Regeneration, Goethe-University Frankfurt am Main

Gene Info

Description: arachidonate 5-lipoxygenase activating protein
Gene AccessionGene NameTax IDStrandPositionGene Biotype
ENSMUSG00000060063 Alox5ap 10090 + 5:149265058-149288045 protein_coding
  Transcript Accession Transcript Name Position Transcript Biotype
  ENSMUST00000071130 Alox5ap-201 149265058-149288045 protein_coding
  ENSMUST00000130144 Alox5ap-001 149265058-149265182 protein_coding

Expression Patterns

Heat Map
Numeric Values
Transcript'; AdiposeAdrenalBladderBrainBreastColonHeartKidneyLiverLungMuscleOvaryPlacentaTestisENSMUST00000071130
Transcript ID Adipose Adrenal Bladder Brain Breast Colon Heart Kidney Liver Lung Muscle Ovary Placenta Testis
ENSMUST00000071130 30.734±2.20 6.958±0.80 17.231±0.52 2.624±0.11 36.862±1.71 9.292±0.97 9.517±1.78 6.413±0.60 14.575±16.08 54.623±4.14 0.965±0.32 21.387±7.79 4.280±3.07 1.286±0.61

Conserved Regions

Region IDSub-RegionRegion TypePosition
CIL_0007UA CIL_0007UA_0002 VISTA 5:149020224-149622595
CIL_0004CN CIL_0004CN_0003 CGP 5:149184350-149288045
CIL_0002AA CIL_0002AA_0002 CGP 5:149265058-149431723

Gene Ontology
GO IDEvidence TypeGO Description
GO:0002540 IMP leukotriene production involved in inflammatory response
GO:0002675 IEA positive regulation of acute inflammatory response
GO:0004051 IEA arachidonate 5-lipoxygenase activity
GO:0005515 IPI protein binding
GO:0005634 IDA nucleus
GO:0005635 IBA:ISS nuclear envelope
GO:0005783 IBA endoplasmic reticulum
GO:0005829 IEA cytosol
GO:0008047 IEA enzyme activator activity
GO:0016020 IEA membrane
GO:0016021 IEA integral component of membrane
GO:0019370 IDA leukotriene biosynthetic process
GO:0019899 IEA enzyme binding
GO:0031965 ISS nuclear membrane
GO:0042803 IEA protein homodimerization activity
GO:0043085 IEA positive regulation of catalytic activity
GO:0046982 IEA protein heterodimerization activity
GO:0047485 IEA protein N-terminus binding
GO:0050544 ISS arachidonic acid binding
GO:0055114 IEA oxidation-reduction process
GO:0070207 IEA protein homotrimerization
GO:0071277 IEA cellular response to calcium ion

Homologs

ENSEMBL Accession Gene Name Description Biotype Species
ENSDARG00000054755 alox5ap arachidonate 5-lipoxygenase-activating protein protein_coding Danio_rerio
ENSG00000132965 ALOX5AP arachidonate 5-lipoxygenase-activating protein protein_coding Homo_sapiens

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