C-It-Loci: A knowledge database for tissue-enriched loci.

Institute of Cardiovascular Regeneration, Goethe-University Frankfurt am Main

Gene Info

Description: arachidonate 5-lipoxygenase-activating protein
Gene AccessionGene NameTax IDStrandPositionGene Biotype
ENSG00000132965 ALOX5AP 9606 + 13:30713478-30764426 protein_coding
  Transcript Accession Transcript Name Position Transcript Biotype
  ENST00000380490 ALOX5AP-001 30735508-30764426 protein_coding
  ENST00000479597 ALOX5AP-002 30742336-30744396 processed_transcript
  ENST00000617770 ALOX5AP-201 30713478-30764425 protein_coding

Expression Patterns

Heat Map
Numeric Values
Transcript'; AdiposeAdrenalBladderBrainBreastColonHeartKidneyLiverLungMuscleOvaryPlacentaTestisENST00000380490ENST00000617770
Transcript ID Adipose Adrenal Bladder Brain Breast Colon Heart Kidney Liver Lung Muscle Ovary Placenta Testis
ENST00000380490 19.582±0.00 19.031±0.00 0.351±0.00 8.243±4.61 4.673±3.89 6.479±0.85 4.988±2.66 8.348±7.70 3.673±1.52 47.109±18.02 1.664±0.00 6.689±2.62 28.034±3.74 4.166±2.37
ENST00000617770 N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A 0.204±0.00

Conserved Regions

Region IDSub-RegionRegion TypePosition
CIL_0007UA CIL_0007UA_0001 VISTA 13:30490781-31093754
CIL_0004CN CIL_0004CN_0002 CGP 13:30617693-30764426
CIL_0002AA CIL_0002AA_0001 CGP 13:30713478-30925572

Gene Ontology
GO IDEvidence TypeGO Description
GO:0002540 IEA leukotriene production involved in inflammatory response
GO:0002675 IEA positive regulation of acute inflammatory response
GO:0004051 IEA arachidonate 5-lipoxygenase activity
GO:0005515 IPI protein binding
GO:0005634 IEA nucleus
GO:0005635 IDA nuclear envelope
GO:0005783 IDA endoplasmic reticulum
GO:0005829 IEA cytosol
GO:0006691 TAS leukotriene metabolic process
GO:0008047 IEA enzyme activator activity
GO:0016020 IDA membrane
GO:0016021 IEA integral component of membrane
GO:0019369 TAS arachidonic acid metabolic process
GO:0019370 IDA leukotriene biosynthetic process
GO:0019372 TAS lipoxygenase pathway
GO:0019899 IEA enzyme binding
GO:0031965 IDA nuclear membrane
GO:0042803 IEA protein homodimerization activity
GO:0043085 IEA positive regulation of catalytic activity
GO:0044281 TAS small molecule metabolic process
GO:0046982 IEA protein heterodimerization activity
GO:0047485 IPI protein N-terminus binding
GO:0050544 IDA arachidonic acid binding
GO:0055114 IEA oxidation-reduction process
GO:0070207 IPI protein homotrimerization
GO:0071277 IDA cellular response to calcium ion
GO:2001300 TAS lipoxin metabolic process

Homologs

ENSEMBL Accession Gene Name Description Biotype Species
ENSDARG00000054755 alox5ap arachidonate 5-lipoxygenase-activating protein protein_coding Danio_rerio
ENSMUSG00000060063 Alox5ap arachidonate 5-lipoxygenase activating protein protein_coding Mus_musculus

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