C-It-Loci: A knowledge database for tissue-enriched loci.

Institute of Cardiovascular Regeneration, Goethe-University Frankfurt am Main

Gene Info

Description: interleukin-1 receptor-associated kinase 2
Gene AccessionGene NameTax IDStrandPositionGene Biotype
ENSMUSG00000060477 Irak2 10090 + 6:113638467-113695009 protein_coding
  Transcript Accession Transcript Name Position Transcript Biotype
  ENSMUST00000059286 Irak2-001 113638467-113695009 protein_coding
  ENSMUST00000089022 Irak2-004 113638528-113695009 protein_coding
  ENSMUST00000089023 Irak2-002 113638488-113693798 protein_coding
  ENSMUST00000113024 Irak2-005 113669778-113693798 protein_coding
  ENSMUST00000143948 Irak2-007 113692759-113694007 processed_transcript
  ENSMUST00000155554 Irak2-006 113668850-113672939 protein_coding

Expression Patterns

Heat Map
Numeric Values
Transcript'; AdiposeAdrenalBladderBrainBreastColonHeartKidneyLiverLungMuscleOvaryPlacentaTestisENSMUST00000059286ENSMUST00000089022ENSMUST00000089023ENSMUST00000113024
Transcript ID Adipose Adrenal Bladder Brain Breast Colon Heart Kidney Liver Lung Muscle Ovary Placenta Testis
ENSMUST00000059286 14.744±7.16 3.835±1.45 8.739±1.64 0.502±0.00 6.792±4.25 10.600±3.48 2.284±0.63 11.145±1.29 4.171±1.13 10.042±0.69 0.822±0.31 4.406±1.77 5.627±1.83 0.475±0.17
ENSMUST00000089022 3.968±2.03 1.445±0.16 7.866±1.19 0.662±0.47 4.928±1.23 6.122±1.31 0.832±0.08 3.450±0.28 2.618±1.32 4.002±0.65 0.706±0.13 1.690±0.86 6.076±3.76 0.232±0.00
ENSMUST00000089023 N/A 2.306±0.87 N/A N/A 3.797±0.00 4.147±0.00 N/A N/A 2.034±0.00 3.378±0.00 N/A 2.061±0.53 N/A N/A
ENSMUST00000113024 N/A 1.239±0.26 N/A N/A 3.350±0.72 4.085±0.36 N/A N/A 1.273±0.00 N/A N/A N/A N/A N/A

Conserved Regions

Region IDSub-RegionRegion TypePosition
CIL_00061P CIL_00061P_0002 CGP 6:113623959-113695009
CIL_00061O CIL_00061O_0002 CGP 6:113638467-113711069

Gene Ontology
GO IDEvidence TypeGO Description
GO:0001959 IEA regulation of cytokine-mediated signaling pathway
GO:0004672 ISO protein kinase activity
GO:0005515 IPI protein binding
GO:0005524 IEA ATP binding
GO:0006468 ISO protein phosphorylation
GO:0031663 IDA lipopolysaccharide-mediated signaling pathway
GO:0032088 IEA negative regulation of NF-kappaB transcription factor activity
GO:0042803 IEA protein homodimerization activity
GO:0042981 RCA regulation of apoptotic process
GO:0043433 IDA negative regulation of sequence-specific DNA binding transcription factor activity
GO:0046982 IEA protein heterodimerization activity
GO:0051092 IDA positive regulation of NF-kappaB transcription factor activity
GO:0070498 IEA interleukin-1-mediated signaling pathway
GO:0070555 IEA response to interleukin-1

Homologs

ENSEMBL Accession Gene Name Description Biotype Species
ENSG00000134070 IRAK2 interleukin-1 receptor-associated kinase 2 protein_coding Homo_sapiens

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