C-It-Loci: A knowledge database for tissue-enriched loci.

Institute of Cardiovascular Regeneration, Goethe-University Frankfurt am Main

Gene Info

Description: mitogen-activated protein kinase 1
Gene AccessionGene NameTax IDStrandPositionGene Biotype
ENSMUSG00000063358 Mapk1 10090 + 16:16983382-17047453 protein_coding
  Transcript Accession Transcript Name Position Transcript Biotype
  ENSMUST00000023462 Mapk1-002 16983382-17044749 protein_coding
  ENSMUST00000069107 Mapk1-001 16983382-17047453 protein_coding
  ENSMUST00000115731 Mapk1-003 16983567-17039040 protein_coding
  ENSMUST00000128958 Mapk1-008 17035338-17038705 processed_transcript
  ENSMUST00000129477 Mapk1-006 17026366-17043863 protein_coding
  ENSMUST00000138165 Mapk1-005 17026026-17027194 retained_intron
  ENSMUST00000138413 Mapk1-004 17018413-17024055 retained_intron
  ENSMUST00000145409 Mapk1-007 17035549-17044210 processed_transcript

Expression Patterns

Heat Map
Numeric Values
Transcript'; AdiposeAdrenalBladderBrainBreastColonHeartKidneyLiverLungMuscleOvaryPlacentaTestisENSMUST00000023462ENSMUST00000069107ENSMUST00000115731ENSMUST00000145409
Transcript ID Adipose Adrenal Bladder Brain Breast Colon Heart Kidney Liver Lung Muscle Ovary Placenta Testis
ENSMUST00000023462 9.591±2.22 11.667±0.10 26.922±3.85 33.271±13.60 10.507±4.50 22.180±5.90 11.243±0.98 8.171±1.91 16.427±6.15 12.343±4.27 12.402±0.79 18.128±5.06 27.646±5.68 4.466±1.22
ENSMUST00000069107 16.080±6.39 15.704±2.01 24.914±1.81 29.539±6.62 15.559±3.28 12.258±1.45 13.512±0.39 19.598±1.97 16.600±4.89 17.942±1.98 9.956±0.59 20.458±2.38 16.087±6.00 4.979±0.33
ENSMUST00000115731 N/A N/A N/A N/A N/A N/A N/A N/A 11.222±3.28 N/A 7.548±0.62 15.518±3.17 22.537±8.75 4.306±0.00
ENSMUST00000145409 20.188±1.59 35.505±2.51 N/A N/A 19.614±1.19 N/A N/A N/A 16.049±0.00 N/A N/A 54.578±0.00 N/A 12.088±4.64

Conserved Regions

Region IDSub-RegionRegion TypePosition
CIL_0008PT CIL_0008PT_0002 VISTA 16:16870677-17470725

Gene Ontology
GO IDEvidence TypeGO Description
GO:0000165 IDA MAPK cascade
GO:0000189 IEA MAPK import into nucleus
GO:0001784 IMP phosphotyrosine binding
GO:0004672 IDA protein kinase activity
GO:0004674 IDA protein serine/threonine kinase activity
GO:0004707 IMP MAP kinase activity
GO:0005515 IPI protein binding
GO:0005524 IEA ATP binding
GO:0005634 IDA nucleus
GO:0005654 TAS nucleoplasm
GO:0005737 IDA cytoplasm
GO:0005739 IDA mitochondrion
GO:0005769 TAS early endosome
GO:0005770 TAS late endosome
GO:0005794 TAS Golgi apparatus
GO:0005829 IDA cytosol
GO:0005856 TAS cytoskeleton
GO:0005901 TAS caveola
GO:0005925 TAS focal adhesion
GO:0006351 NAS transcription, DNA-templated
GO:0006468 IDA protein phosphorylation
GO:0006915 IEA apoptotic process
GO:0006974 IDA cellular response to DNA damage stimulus
GO:0007049 IEA cell cycle
GO:0007165 IEA signal transduction
GO:0008134 IEA transcription factor binding
GO:0008284 IEA positive regulation of cell proliferation
GO:0008353 IDA RNA polymerase II carboxy-terminal domain kinase activity
GO:0009636 IEA response to toxic substance
GO:0009887 IDA organ morphogenesis
GO:0010800 IEA positive regulation of peptidyl-threonine phosphorylation
GO:0015630 IEA microtubule cytoskeleton
GO:0016301 IDA kinase activity
GO:0018105 IDA peptidyl-serine phosphorylation
GO:0018107 IDA peptidyl-threonine phosphorylation
GO:0019233 IEA sensory perception of pain
GO:0019858 IDA cytosine metabolic process
GO:0019901 IEA protein kinase binding
GO:0019902 IEA phosphatase binding
GO:0030335 IEA positive regulation of cell migration
GO:0030424 IEA axon
GO:0031143 IDA pseudopodium
GO:0031435 IEA mitogen-activated protein kinase kinase kinase binding
GO:0031647 ISS regulation of protein stability
GO:0031663 IDA lipopolysaccharide-mediated signaling pathway
GO:0032496 IDA response to lipopolysaccharide
GO:0032839 IEA dendrite cytoplasm
GO:0032872 TAS regulation of stress-activated MAPK cascade
GO:0033598 IDA mammary gland epithelial cell proliferation
GO:0035556 IEA intracellular signal transduction
GO:0038127 IEA ERBB signaling pathway
GO:0043204 IEA perikaryon
GO:0043234 IEA protein complex
GO:0043330 IDA response to exogenous dsRNA
GO:0043627 IEA response to estrogen
GO:0045596 IGI negative regulation of cell differentiation
GO:0045727 IEA positive regulation of translation
GO:0045893 IEA positive regulation of transcription, DNA-templated
GO:0050852 IDA T cell receptor signaling pathway
GO:0050853 IDA B cell receptor signaling pathway
GO:0051090 NAS regulation of sequence-specific DNA binding transcription factor activity
GO:0051493 TAS regulation of cytoskeleton organization
GO:0060716 IMP labyrinthine layer blood vessel development
GO:0070062 IEA extracellular vesicular exosome
GO:0070371 IEA ERK1 and ERK2 cascade
GO:0070849 ISS response to epidermal growth factor
GO:0071310 IEA cellular response to organic substance
GO:0072584 TAS caveolin-mediated endocytosis
GO:0072686 ISS mitotic spindle
GO:0090170 TAS regulation of Golgi inheritance
GO:0097011 IDA cellular response to granulocyte macrophage colony-stimulating factor stimulus
GO:2000641 TAS regulation of early endosome to late endosome transport

Homologs

ENSEMBL Accession Gene Name Description Biotype Species
ENSDARG00000027552 mapk1 mitogen-activated protein kinase 1 protein_coding Danio_rerio
ENSG00000100030 MAPK1 mitogen-activated protein kinase 1 protein_coding Homo_sapiens

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