C-It-Loci: A knowledge database for tissue-enriched loci.

Institute of Cardiovascular Regeneration, Goethe-University Frankfurt am Main

Gene Info

Description: mitogen-activated protein kinase 1
Gene AccessionGene NameTax IDStrandPositionGene Biotype
ENSG00000100030 MAPK1 9606 - 22:21754500-21867680 protein_coding
  Transcript Accession Transcript Name Position Transcript Biotype
  ENST00000215832 MAPK1-001 21754500-21867629 protein_coding
  ENST00000398822 MAPK1-002 21769040-21867680 protein_coding
  ENST00000491588 MAPK1-003 21763984-21769428 processed_transcript
  ENST00000544786 MAPK1-201 21769204-21867440 protein_coding

Expression Patterns

Heat Map
Numeric Values
Transcript'; AdiposeBladderBrainBreastColonHeartKidneyLiverLungMuscleOvaryPlacentaTestisENST00000215832ENST00000398822ENST00000544786
Transcript ID Adipose Bladder Brain Breast Colon Heart Kidney Liver Lung Muscle Ovary Placenta Testis
ENST00000215832 N/A 2.275±0.00 17.453±7.56 3.273±0.00 5.743±2.30 1.429±0.00 2.288±0.00 1.908±0.00 2.523±0.00 3.374±2.10 4.639±3.64 7.267±0.00 7.081±0.00
ENST00000398822 11.322±0.00 2.983±0.00 14.817±0.00 N/A 4.123±0.00 8.022±4.84 7.973±0.00 8.762±0.00 13.020±0.00 3.056±0.00 11.325±1.33 11.886±1.33 22.460±0.04
ENST00000544786 N/A 5.348±0.00 28.663±0.00 8.118±0.00 11.444±0.00 N/A N/A 8.246±0.00 12.007±0.00 9.355±3.00 23.067±0.00 N/A 23.240±0.00

Conserved Regions

Region IDSub-RegionRegion TypePosition
CIL_0008PT CIL_0008PT_0001 VISTA 22:21299079-21900013
CIL_0003KO CIL_0003KO_0002 CGP 22:21697544-21867680
CIL_0003KZ CIL_0003KZ_0002 CGP 22:21754500-21952837

Gene Ontology
GO IDEvidence TypeGO Description
GO:0000165 TAS MAPK cascade
GO:0000186 TAS activation of MAPKK activity
GO:0000187 TAS activation of MAPK activity
GO:0000189 IEA MAPK import into nucleus
GO:0001784 IEA phosphotyrosine binding
GO:0002224 TAS toll-like receptor signaling pathway
GO:0002755 TAS MyD88-dependent toll-like receptor signaling pathway
GO:0002756 TAS MyD88-independent toll-like receptor signaling pathway
GO:0003677 IEA DNA binding
GO:0004672 IEA protein kinase activity
GO:0004674 IDA protein serine/threonine kinase activity
GO:0004707 IEA MAP kinase activity
GO:0004713 IEA protein tyrosine kinase activity
GO:0005515 IPI protein binding
GO:0005524 IEA ATP binding
GO:0005634 IDA nucleus
GO:0005654 TAS nucleoplasm
GO:0005737 ISS cytoplasm
GO:0005739 TAS mitochondrion
GO:0005769 TAS early endosome
GO:0005770 TAS late endosome
GO:0005794 TAS Golgi apparatus
GO:0005829 TAS cytosol
GO:0005856 TAS cytoskeleton
GO:0005901 TAS caveola
GO:0005925 TAS focal adhesion
GO:0006351 IEA transcription, DNA-templated
GO:0006468 IEA protein phosphorylation
GO:0006915 IEA apoptotic process
GO:0006935 TAS chemotaxis
GO:0006950 TAS response to stress
GO:0006974 IEA cellular response to DNA damage stimulus
GO:0007049 IEA cell cycle
GO:0007165 TAS signal transduction
GO:0007173 TAS epidermal growth factor receptor signaling pathway
GO:0007264 TAS small GTPase mediated signal transduction
GO:0007265 TAS Ras protein signal transduction
GO:0007268 TAS synaptic transmission
GO:0007411 TAS axon guidance
GO:0007596 TAS blood coagulation
GO:0008134 IEA transcription factor binding
GO:0008284 IEA positive regulation of cell proliferation
GO:0008286 TAS insulin receptor signaling pathway
GO:0008353 ISS RNA polymerase II carboxy-terminal domain kinase activity
GO:0008543 TAS fibroblast growth factor receptor signaling pathway
GO:0009636 IEA response to toxic substance
GO:0009887 IEA organ morphogenesis
GO:0010800 IDA positive regulation of peptidyl-threonine phosphorylation
GO:0015630 IDA microtubule cytoskeleton
GO:0016032 IEA viral process
GO:0016301 IEA kinase activity
GO:0016772 IEA transferase activity, transferring phosphorus-containing groups
GO:0018105 IDA peptidyl-serine phosphorylation
GO:0018107 ISS peptidyl-threonine phosphorylation
GO:0019233 IEA sensory perception of pain
GO:0019858 IEA cytosine metabolic process
GO:0019901 IEA protein kinase binding
GO:0019902 IPI phosphatase binding
GO:0030168 TAS platelet activation
GO:0030335 IEA positive regulation of cell migration
GO:0030424 IEA axon
GO:0031143 IEA pseudopodium
GO:0031435 IEA mitogen-activated protein kinase kinase kinase binding
GO:0031647 ISS regulation of protein stability
GO:0031663 IEA lipopolysaccharide-mediated signaling pathway
GO:0032496 IEA response to lipopolysaccharide
GO:0032839 IEA dendrite cytoplasm
GO:0032872 TAS regulation of stress-activated MAPK cascade
GO:0033598 IEA mammary gland epithelial cell proliferation
GO:0034134 TAS toll-like receptor 2 signaling pathway
GO:0034138 TAS toll-like receptor 3 signaling pathway
GO:0034142 TAS toll-like receptor 4 signaling pathway
GO:0034146 TAS toll-like receptor 5 signaling pathway
GO:0034162 TAS toll-like receptor 9 signaling pathway
GO:0034166 TAS toll-like receptor 10 signaling pathway
GO:0035556 IEA intracellular signal transduction
GO:0035666 TAS TRIF-dependent toll-like receptor signaling pathway
GO:0038095 TAS Fc-epsilon receptor signaling pathway
GO:0038096 TAS Fc-gamma receptor signaling pathway involved in phagocytosis
GO:0038123 TAS toll-like receptor TLR1:TLR2 signaling pathway
GO:0038124 TAS toll-like receptor TLR6:TLR2 signaling pathway
GO:0038127 IDA ERBB signaling pathway
GO:0043204 IEA perikaryon
GO:0043234 IEA protein complex
GO:0043330 IEA response to exogenous dsRNA
GO:0043627 IEA response to estrogen
GO:0045087 TAS innate immune response
GO:0045596 IEA negative regulation of cell differentiation
GO:0045727 IEA positive regulation of translation
GO:0045893 IEA positive regulation of transcription, DNA-templated
GO:0048011 TAS neurotrophin TRK receptor signaling pathway
GO:0050852 IEA T cell receptor signaling pathway
GO:0050853 IEA B cell receptor signaling pathway
GO:0051090 TAS regulation of sequence-specific DNA binding transcription factor activity
GO:0051403 TAS stress-activated MAPK cascade
GO:0051493 TAS regulation of cytoskeleton organization
GO:0060397 TAS JAK-STAT cascade involved in growth hormone signaling pathway
GO:0060716 IEA labyrinthine layer blood vessel development
GO:0070062 IDA extracellular vesicular exosome
GO:0070371 IDA ERK1 and ERK2 cascade
GO:0070849 IDA response to epidermal growth factor
GO:0071310 IEA cellular response to organic substance
GO:0072584 TAS caveolin-mediated endocytosis
GO:0072686 ISS mitotic spindle
GO:0090170 TAS regulation of Golgi inheritance
GO:0097011 IEA cellular response to granulocyte macrophage colony-stimulating factor stimulus
GO:2000641 TAS regulation of early endosome to late endosome transport

Homologs

ENSEMBL Accession Gene Name Description Biotype Species
ENSDARG00000027552 mapk1 mitogen-activated protein kinase 1 protein_coding Danio_rerio
ENSMUSG00000063358 Mapk1 mitogen-activated protein kinase 1 protein_coding Mus_musculus

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