C-It-Loci: A knowledge database for tissue-enriched loci.

Institute of Cardiovascular Regeneration, Goethe-University Frankfurt am Main

Gene Info

Description: mitogen-activated protein kinase kinase kinase 5
Gene AccessionGene NameTax IDStrandPositionGene Biotype
ENSMUSG00000071369 Map3k5 10090 + 10:19934472-20142753 protein_coding
  Transcript Accession Transcript Name Position Transcript Biotype
  ENSMUST00000095806 Map3k5-001 19934472-20142753 protein_coding
  ENSMUST00000120259 Map3k5-002 19934526-20141670 protein_coding
  ENSMUST00000129437 Map3k5-003 19935223-20100158 protein_coding
  ENSMUST00000138994 Map3k5-005 20099525-20105437 processed_transcript
  ENSMUST00000142726 Map3k5-007 20127684-20138551 retained_intron
  ENSMUST00000152533 Map3k5-004 19951055-20023699 protein_coding
  ENSMUST00000156369 Map3k5-006 20124801-20127684 retained_intron

Expression Patterns

Heat Map
Numeric Values
Transcript'; AdiposeAdrenalBladderBrainBreastColonHeartKidneyLiverLungMuscleOvaryPlacentaTestisENSMUST00000095806ENSMUST00000120259ENSMUST00000142726
Transcript ID Adipose Adrenal Bladder Brain Breast Colon Heart Kidney Liver Lung Muscle Ovary Placenta Testis
ENSMUST00000095806 1.945±0.52 0.816±0.02 10.415±0.10 0.881±0.63 1.545±0.61 1.401±0.39 3.220±0.15 3.488±0.80 1.135±0.26 3.190±0.37 1.042±0.22 5.420±4.92 2.582±0.10 0.175±0.00
ENSMUST00000120259 1.044±0.20 0.939±0.23 N/A 1.155±1.44 1.018±0.28 0.754±0.00 1.487±0.37 1.150±0.21 0.501±0.01 1.302±0.24 N/A 2.352±0.94 0.605±0.00 0.189±0.07
ENSMUST00000142726 N/A N/A N/A 11.419±0.00 N/A N/A N/A N/A 2.671±0.00 N/A N/A 21.346±0.00 4.251±0.88 1.721±1.13

Conserved Regions

Gene is not located within a conserved region.

Gene Ontology
GO IDEvidence TypeGO Description
GO:0000165 ISS MAPK cascade
GO:0000186 IEA activation of MAPKK activity
GO:0000187 IDA activation of MAPK activity
GO:0000287 ISS magnesium ion binding
GO:0001934 IEA positive regulation of protein phosphorylation
GO:0002931 IEA response to ischemia
GO:0004674 IEA protein serine/threonine kinase activity
GO:0004709 IDA MAP kinase kinase kinase activity
GO:0005515 IPI protein binding
GO:0005524 IEA:ISS ATP binding
GO:0005783 IEA endoplasmic reticulum
GO:0006468 IEA protein phosphorylation
GO:0006919 IEA activation of cysteine-type endopeptidase activity involved in apoptotic process
GO:0007254 IEA JNK cascade
GO:0008631 IDA intrinsic apoptotic signaling pathway in response to oxidative stress
GO:0008656 ISS cysteine-type endopeptidase activator activity involved in apoptotic process
GO:0010941 IGI regulation of cell death
GO:0019901 IPI protein kinase binding
GO:0019903 IEA protein phosphatase binding
GO:0042803 ISS protein homodimerization activity
GO:0043065 IDA positive regulation of apoptotic process
GO:0043280 IEA positive regulation of cysteine-type endopeptidase activity involved in apoptotic process
GO:0045087 IEA innate immune response
GO:0070301 IEA cellular response to hydrogen peroxide
GO:0097300 IMP programmed necrotic cell death
GO:1901216 IEA positive regulation of neuron death
GO:1902170 IMP cellular response to reactive nitrogen species
GO:1902911 IEA protein kinase complex

Homologs

ENSEMBL Accession Gene Name Description Biotype Species
ENSDARG00000005416 map3k5 mitogen-activated protein kinase kinase kinase 5 protein_coding Danio_rerio
ENSG00000197442 MAP3K5 mitogen-activated protein kinase kinase kinase 5 protein_coding Homo_sapiens

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