C-It-Loci: A knowledge database for tissue-enriched loci.

Institute of Cardiovascular Regeneration, Goethe-University Frankfurt am Main

Transcript Info
Description: mitogen-activated protein kinase kinase kinase 5
Transcript Accession Transcript Name Contained in Gene Tax ID Strand Position Biotype
ENSMUST00000095806 Map3k5-001 ENSMUSG00000071369 10090 + 10:19934472-20142753 protein_coding

Expression Patterns

Heat Map
Numeric Values
Transcript'; AdiposeAdrenalBladderBrainBreastColonHeartKidneyLiverLungMuscleOvaryPlacentaTestisENSMUST00000095806
Transcript ID Adipose Adrenal Bladder Brain Breast Colon Heart Kidney Liver Lung Muscle Ovary Placenta Testis
ENSMUST00000095806 1.945±0.52 0.816±0.02 10.415±0.10 0.881±0.63 1.545±0.61 1.401±0.39 3.220±0.15 3.488±0.80 1.135±0.26 3.190±0.37 1.042±0.22 5.420±4.92 2.582±0.10 0.175±0.00

Conserved Regions

Gene is not located within a conserved region.

Gene Ontology

GO IDEvidence TypeGO Description
GO:0000165 ISS MAPK cascade
GO:0000186 IEA activation of MAPKK activity
GO:0000187 IDA activation of MAPK activity
GO:0000287 ISS magnesium ion binding
GO:0001934 IEA positive regulation of protein phosphorylation
GO:0002931 IEA response to ischemia
GO:0004709 IDA MAP kinase kinase kinase activity
GO:0005515 IPI protein binding
GO:0005524 IEA:ISS ATP binding
GO:0005783 IEA endoplasmic reticulum
GO:0006468 IEA protein phosphorylation
GO:0006919 IEA activation of cysteine-type endopeptidase activity involved in apoptotic process
GO:0007254 IEA JNK cascade
GO:0008631 IDA intrinsic apoptotic signaling pathway in response to oxidative stress
GO:0008656 ISS cysteine-type endopeptidase activator activity involved in apoptotic process
GO:0010941 IGI regulation of cell death
GO:0019901 IPI protein kinase binding
GO:0019903 IEA protein phosphatase binding
GO:0042803 ISS protein homodimerization activity
GO:0043065 IDA positive regulation of apoptotic process
GO:0043280 IEA positive regulation of cysteine-type endopeptidase activity involved in apoptotic process
GO:0045087 IEA innate immune response
GO:0070301 IEA cellular response to hydrogen peroxide
GO:0097300 IMP programmed necrotic cell death
GO:1901216 IEA positive regulation of neuron death
GO:1902170 IMP cellular response to reactive nitrogen species
GO:1902911 IEA protein kinase complex

Homologs

ENSEMBL Accession Gene Name Biotype Species E-Value Bit Score
ENSDART00000046641 map3k5-201 protein_coding Danio_rerio 0 1171
ENSDART00000152495 map3k5-001 protein_coding Danio_rerio 0 1072
ENST00000359015 MAP3K5-001 protein_coding Homo_sapiens 0 4817
ENST00000463140 MAP3K5-002 processed_transcript Homo_sapiens 0 324

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