C-It-Loci: A knowledge database for tissue-enriched loci.

Institute of Cardiovascular Regeneration, Goethe-University Frankfurt am Main

Gene Info

Description: deiodinase, iodothyronine type III
Gene AccessionGene NameTax IDStrandPositionGene Biotype
ENSMUSG00000075707 Dio3 10090 + 12:110279068-110281097 protein_coding
  Transcript Accession Transcript Name Position Transcript Biotype
  ENSMUST00000097228 Dio3-201 110279260-110280708 protein_coding
  ENSMUST00000173014 Dio3-001 110279068-110281097 protein_coding

Expression Patterns

Heat Map
Numeric Values
Transcript'; AdiposeBladderBrainBreastColonHeartKidneyLiverLungMuscleOvaryPlacentaTestisENSMUST00000097228ENSMUST00000173014
Transcript ID Adipose Bladder Brain Breast Colon Heart Kidney Liver Lung Muscle Ovary Placenta Testis
ENSMUST00000097228 0.373±0.26 0.125±0.06 1.770±0.71 0.162±0.04 0.268±0.05 0.125±0.04 0.170±0.09 0.060±0.03 0.176±0.00 0.071±0.05 N/A 8.468±3.72 0.091±0.03
ENSMUST00000173014 0.549±0.39 0.207±0.03 0.855±0.19 0.037±0.00 0.166±0.02 0.052±0.00 0.108±0.04 0.089±0.03 0.096±0.02 0.162±0.08 2.135±1.26 17.531±13.59 0.113±0.06

Conserved Regions

Region IDSub-RegionRegion TypePosition
CIL_0004AB CIL_0004AB_0002 CGP 12:109589194-110281097
CIL_0004A7 CIL_0004A7_0002 CGP 12:110279068-110583061

Gene Ontology
GO IDEvidence TypeGO Description
GO:0004800 IMP thyroxine 5'-deiodinase activity
GO:0005768 IEA endosome
GO:0005886 IEA plasma membrane
GO:0016021 IEA integral component of membrane
GO:0033798 IDA thyroxine 5-deiodinase activity
GO:0040018 IMP positive regulation of multicellular organism growth
GO:0042404 IMP thyroid hormone catabolic process
GO:0042446 IEA hormone biosynthetic process
GO:0055114 IEA oxidation-reduction process

Homologs

ENSEMBL Accession Gene Name Description Biotype Species
ENSDARG00000089937 dio3a deiodinase, iodothyronine, type IIIa protein_coding Danio_rerio
ENSG00000197406 DIO3 deiodinase, iodothyronine, type III protein_coding Homo_sapiens

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