C-It-Loci: A knowledge database for tissue-enriched loci.

Institute of Cardiovascular Regeneration, Goethe-University Frankfurt am Main

Gene Info

Description: SRY (sex determining region Y)-box 4
Gene AccessionGene NameTax IDStrandPositionGene Biotype
ENSMUSG00000076431 Sox4 10090 - 13:28948919-28953713 protein_coding
  Transcript Accession Transcript Name Position Transcript Biotype
  ENSMUST00000067230 Sox4-001 28948919-28953713 protein_coding

Expression Patterns

Heat Map
Numeric Values
Transcript'; AdiposeAdrenalBladderBrainBreastColonHeartKidneyLiverLungMuscleOvaryPlacentaTestisENSMUST00000067230
Transcript ID Adipose Adrenal Bladder Brain Breast Colon Heart Kidney Liver Lung Muscle Ovary Placenta Testis
ENSMUST00000067230 21.778±11.75 24.599±3.55 10.782±1.50 96.090±71.39 19.611±11.87 14.696±1.59 4.543±0.87 5.256±1.77 1.501±1.12 19.641±4.43 0.649±0.19 113.057±44.33 4.087±1.41 0.804±0.28

Conserved Regions

Region IDSub-RegionRegion TypePosition
CIL_0008YC CIL_0008YC_0002 VISTA 13:28417646-29019441
CIL_00084D CIL_00084D_0002 VISTA 13:28658215-29260360
CIL_0005MW CIL_0005MW_0002 CGP 13:28948919-29855674

Gene Ontology
GO IDEvidence TypeGO Description
GO:0000976 IDA transcription regulatory region sequence-specific DNA binding
GO:0000981 IDA sequence-specific DNA binding RNA polymerase II transcription factor activity
GO:0001046 IDA core promoter sequence-specific DNA binding
GO:0001071 ISS nucleic acid binding transcription factor activity
GO:0001077 IDA RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription
GO:0001105 IDA RNA polymerase II transcription coactivator activity
GO:0001501 IMP skeletal system development
GO:0001841 IMP neural tube formation
GO:0002328 IMP pro-B cell differentiation
GO:0003183 IMP mitral valve morphogenesis
GO:0003211 IMP cardiac ventricle formation
GO:0003215 IMP cardiac right ventricle morphogenesis
GO:0003289 IMP atrial septum primum morphogenesis
GO:0003357 IMP noradrenergic neuron differentiation
GO:0003700 ISS sequence-specific DNA binding transcription factor activity
GO:0005515 IPI protein binding
GO:0005634 ISS nucleus
GO:0005737 ISS cytoplasm
GO:0005739 ISS mitochondrion
GO:0006355 ISS regulation of transcription, DNA-templated
GO:0006366 IDA transcription from RNA polymerase II promoter
GO:0006977 ISS DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest
GO:0007507 IMP heart development
GO:0008284 ISS positive regulation of cell proliferation
GO:0008285 ISS negative regulation of cell proliferation
GO:0014009 IMP glial cell proliferation
GO:0021510 IMP spinal cord development
GO:0021522 IMP spinal cord motor neuron differentiation
GO:0021782 IMP glial cell development
GO:0030177 IMP positive regulation of Wnt signaling pathway
GO:0030217 IMP T cell differentiation
GO:0031018 IMP endocrine pancreas development
GO:0031397 ISS negative regulation of protein ubiquitination
GO:0031647 ISS regulation of protein stability
GO:0032024 IMP positive regulation of insulin secretion
GO:0035019 IDA somatic stem cell maintenance
GO:0035910 IMP ascending aorta morphogenesis
GO:0042593 IMP glucose homeostasis
GO:0042769 ISS DNA damage response, detection of DNA damage
GO:0043065 IEA positive regulation of apoptotic process
GO:0044798 IDA nuclear transcription factor complex
GO:0045727 ISS positive regulation of translation
GO:0045893 IDA positive regulation of transcription, DNA-templated
GO:0045944 ISS positive regulation of transcription from RNA polymerase II promoter
GO:0046826 ISS negative regulation of protein export from nucleus
GO:0046982 IDA protein heterodimerization activity
GO:0048485 IMP sympathetic nervous system development
GO:0050821 IMP protein stabilization
GO:0060070 IMP canonical Wnt signaling pathway
GO:0060174 IMP limb bud formation
GO:0060412 IMP ventricular septum morphogenesis
GO:0060548 IMP negative regulation of cell death
GO:0060563 IMP neuroepithelial cell differentiation
GO:0060993 IMP kidney morphogenesis
GO:0071333 IMP cellular response to glucose stimulus
GO:0090263 IDA positive regulation of canonical Wnt signaling pathway
GO:2000761 ISS positive regulation of N-terminal peptidyl-lysine acetylation

Homologs

ENSEMBL Accession Gene Name Description Biotype Species
ENSDARG00000004588 sox4a SRY-box containing gene 4a protein_coding Danio_rerio
ENSDARG00000043235 sox4b SRY-box containing gene 4b protein_coding Danio_rerio
ENSG00000124766 SOX4 SRY (sex determining region Y)-box 4 protein_coding Homo_sapiens

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