C-It-Loci: A knowledge database for tissue-enriched loci.

Institute of Cardiovascular Regeneration, Goethe-University Frankfurt am Main

Transcript Info
Description: hairy/enhancer-of-split related with YRPW motif 2
Transcript Accession Transcript Name Contained in Gene Tax ID Strand Position Biotype
ENSMUST00000019924 Hey2-001 ENSMUSG00000019789 10090 - 10:30832359-30842801 protein_coding

Expression Patterns

Heat Map
Numeric Values
Transcript'; AdiposeAdrenalBladderBrainBreastColonHeartKidneyLiverLungMuscleOvaryPlacentaTestisENSMUST00000019924
Transcript ID Adipose Adrenal Bladder Brain Breast Colon Heart Kidney Liver Lung Muscle Ovary Placenta Testis
ENSMUST00000019924 2.704±1.17 2.916±1.05 0.872±0.02 2.869±1.21 2.107±0.84 2.591±1.03 2.250±0.41 1.181±0.63 0.351±0.13 4.116±1.36 0.142±0.03 41.192±19.74 0.515±0.13 0.441±0.15

Conserved Regions

Region IDSub-RegionRegion TypePosition
CIL_0008OG CIL_0008OG_0002 VISTA 10:30697657-31298999
CIL_0008OH CIL_0008OH_0002 VISTA 10:30727819-31328728
CIL_0008OI CIL_0008OI_0002 VISTA 10:30734051-31335579
CIL_0008OD CIL_0008OD_0002 VISTA 10:30753081-31354088

Gene Ontology

GO IDEvidence TypeGO Description
GO:0000122 IDA negative regulation of transcription from RNA polymerase II promoter
GO:0000983 IDA RNA polymerase II core promoter sequence-specific DNA binding transcription factor activity
GO:0000988 IEA protein binding transcription factor activity
GO:0001102 IEA RNA polymerase II activating transcription factor binding
GO:0001568 IGI blood vessel development
GO:0001570 IGI vasculogenesis
GO:0003150 IMP muscular septum morphogenesis
GO:0003151 IMP outflow tract morphogenesis
GO:0003171 IMP atrioventricular valve development
GO:0003184 IMP pulmonary valve morphogenesis
GO:0003186 IMP tricuspid valve morphogenesis
GO:0003195 IMP tricuspid valve formation
GO:0003199 IGI endocardial cushion to mesenchymal transition involved in heart valve formation
GO:0003208 IMP cardiac ventricle morphogenesis
GO:0003214 IMP cardiac left ventricle morphogenesis
GO:0003215 IMP cardiac right ventricle morphogenesis
GO:0003222 IGI ventricular trabecula myocardium morphogenesis
GO:0003300 IMP cardiac muscle hypertrophy
GO:0003677 IMP DNA binding
GO:0003700 ISS sequence-specific DNA binding transcription factor activity
GO:0005515 IPI protein binding
GO:0005634 IDA nucleus
GO:0005654 TAS nucleoplasm
GO:0005667 ISS transcription factor complex
GO:0005737 IDA cytoplasm
GO:0006357 ISS regulation of transcription from RNA polymerase II promoter
GO:0006366 IDA transcription from RNA polymerase II promoter
GO:0007219 IDA Notch signaling pathway
GO:0007389 IGI pattern specification process
GO:0007507 IEA heart development
GO:0008134 IPI transcription factor binding
GO:0009948 IGI anterior/posterior axis specification
GO:0010460 IMP positive regulation of heart rate
GO:0010468 IMP regulation of gene expression
GO:0010629 IMP negative regulation of gene expression
GO:0010667 IMP negative regulation of cardiac muscle cell apoptotic process
GO:0014031 IMP mesenchymal cell development
GO:0014898 IDA cardiac muscle hypertrophy in response to stress
GO:0016580 IEA Sin3 complex
GO:0017053 IEA transcriptional repressor complex
GO:0035910 IMP ascending aorta morphogenesis
GO:0035912 IGI dorsal aorta morphogenesis
GO:0035939 IDA microsatellite binding
GO:0036304 IGI umbilical cord morphogenesis
GO:0042826 IEA histone deacetylase binding
GO:0043565 IDA sequence-specific DNA binding
GO:0045165 IMP cell fate commitment
GO:0045607 IGI regulation of auditory receptor cell differentiation
GO:0045746 IMP negative regulation of Notch signaling pathway
GO:0045892 IDA negative regulation of transcription, DNA-templated
GO:0045944 IMP positive regulation of transcription from RNA polymerase II promoter
GO:0046983 IEA protein dimerization activity
GO:0055015 IMP ventricular cardiac muscle cell development
GO:0060045 IMP positive regulation of cardiac muscle cell proliferation
GO:0060317 IMP cardiac epithelial to mesenchymal transition
GO:0060347 IMP heart trabecula formation
GO:0060411 IMP cardiac septum morphogenesis
GO:0060412 IMP ventricular septum morphogenesis
GO:0060413 IMP atrial septum morphogenesis
GO:0060633 IEA negative regulation of transcription initiation from RNA polymerase II promoter
GO:0060716 IGI labyrinthine layer blood vessel development
GO:0060840 IGI artery development
GO:0060842 IGI arterial endothelial cell differentiation
GO:0060948 IMP cardiac vascular smooth muscle cell development
GO:0060977 IMP coronary vasculature morphogenesis
GO:0061156 IMP pulmonary artery morphogenesis
GO:0061314 IC Notch signaling involved in heart development
GO:0065004 IDA protein-DNA complex assembly
GO:0090102 IGI cochlea development
GO:0097084 IEA vascular smooth muscle cell development
GO:2000678 IDA negative regulation of transcription regulatory region DNA binding
GO:2000820 IDA negative regulation of transcription from RNA polymerase II promoter involved in smooth muscle cell differentiation
GO:2001212 IGI regulation of vasculogenesis

Homologs

ENSEMBL Accession Gene Name Biotype Species E-Value Bit Score
ENST00000368364 HEY2-001 protein_coding Homo_sapiens 0 1288
ENST00000368365 HEY2-002 protein_coding Homo_sapiens 0 1171

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