C-It-Loci: A knowledge database for tissue-enriched loci.

Institute of Cardiovascular Regeneration, Goethe-University Frankfurt am Main

Transcript Info
Description: retinoblastoma 1
Transcript Accession Transcript Name Contained in Gene Tax ID Strand Position Biotype
ENSMUST00000022701 Rb1-001 ENSMUSG00000022105 10090 - 14:73195502-73325822 protein_coding

Expression Patterns

Heat Map
Numeric Values
Transcript'; AdiposeBladderBrainBreastColonHeartKidneyLiverLungMuscleOvaryPlacentaTestisENSMUST00000022701
Transcript ID Adipose Bladder Brain Breast Colon Heart Kidney Liver Lung Muscle Ovary Placenta Testis
ENSMUST00000022701 7.386±1.16 3.419±0.36 10.927±5.90 5.932±1.78 4.636±0.91 2.888±0.34 4.067±1.58 12.427±4.39 5.993±0.25 3.144±0.31 6.862±2.90 7.371±7.73 4.386±1.39

Conserved Regions

Region IDSub-RegionRegion TypePosition
CIL_00078H CIL_00078H_0003 CGP 14:73183673-73325822

Gene Ontology

GO IDEvidence TypeGO Description
GO:0000082 IMP G1/S transition of mitotic cell cycle
GO:0000122 IDA negative regulation of transcription from RNA polymerase II promoter
GO:0001047 IEA core promoter binding
GO:0001102 IPI RNA polymerase II activating transcription factor binding
GO:0005515 IPI protein binding
GO:0005634 ISS nucleus
GO:0005667 IDA transcription factor complex
GO:0005819 IDA spindle
GO:0006351 IEA transcription, DNA-templated
GO:0006469 ISS negative regulation of protein kinase activity
GO:0007050 IMP cell cycle arrest
GO:0007265 IEA Ras protein signal transduction
GO:0007346 IEA regulation of mitotic cell cycle
GO:0008134 ISS transcription factor binding
GO:0008285 IGI negative regulation of cell proliferation
GO:0016568 IEA chromatin modification
GO:0016605 ISS PML body
GO:0019899 IPI enzyme binding
GO:0019900 ISS kinase binding
GO:0030182 IMP neuron differentiation
GO:0031134 IEA sister chromatid biorientation
GO:0031175 IMP neuron projection development
GO:0031625 IEA ubiquitin protein ligase binding
GO:0034088 IEA maintenance of mitotic sister chromatid cohesion
GO:0034349 IMP glial cell apoptotic process
GO:0035189 IDA Rb-E2F complex
GO:0035914 IMP skeletal muscle cell differentiation
GO:0042551 IMP neuron maturation
GO:0042802 IEA identical protein binding
GO:0043353 IGI enucleate erythrocyte differentiation
GO:0043550 ISS regulation of lipid kinase activity
GO:0045445 ISS myoblast differentiation
GO:0045651 IGI positive regulation of macrophage differentiation
GO:0045786 IMP negative regulation of cell cycle
GO:0045842 IEA positive regulation of mitotic metaphase/anaphase transition
GO:0045879 IMP negative regulation of smoothened signaling pathway
GO:0045892 IDA negative regulation of transcription, DNA-templated
GO:0045930 IGI negative regulation of mitotic cell cycle
GO:0045944 IDA positive regulation of transcription from RNA polymerase II promoter
GO:0048565 IMP digestive tract development
GO:0048667 IMP cell morphogenesis involved in neuron differentiation
GO:0050680 IMP negative regulation of epithelial cell proliferation
GO:0051146 IGI striated muscle cell differentiation
GO:0051219 IEA phosphoprotein binding
GO:0051301 IMP cell division
GO:0051402 IMP neuron apoptotic process
GO:0051726 IMP regulation of cell cycle
GO:0071459 IEA protein localization to chromosome, centromeric region
GO:0071922 IEA regulation of cohesin localization to chromatin
GO:0071930 IGI negative regulation of transcription involved in G1/S transition of mitotic cell cycle
GO:0097284 IMP hepatocyte apoptotic process
GO:2000134 IMP negative regulation of G1/S transition of mitotic cell cycle

Homologs

ENSEMBL Accession Gene Name Biotype Species E-Value Bit Score
ENST00000267163 RB1-002 protein_coding Homo_sapiens 0 3426
ENST00000467505 RB1-003 nonsense_mediated_decay Homo_sapiens 0 228
ENST00000525036 RB1-006 retained_intron Homo_sapiens 0 850

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