C-It-Loci: A knowledge database for tissue-enriched loci.

Institute of Cardiovascular Regeneration, Goethe-University Frankfurt am Main

Transcript Info
Description: glycogen synthase kinase 3 beta
Transcript Accession Transcript Name Contained in Gene Tax ID Strand Position Biotype
ENSMUST00000023507 Gsk3b-001 ENSMUSG00000022812 10090 + 16:38089001-38246084 protein_coding

Expression Patterns

Heat Map
Numeric Values
Transcript'; AdiposeAdrenalBladderBrainBreastColonHeartKidneyLiverLungMuscleOvaryPlacentaTestisENSMUST00000023507
Transcript ID Adipose Adrenal Bladder Brain Breast Colon Heart Kidney Liver Lung Muscle Ovary Placenta Testis
ENSMUST00000023507 8.263±4.12 16.067±3.42 3.645±0.42 13.689±8.31 8.581±3.33 11.413±1.40 2.486±0.35 6.744±1.53 3.049±1.18 16.169±0.87 5.455±0.76 18.077±8.41 4.092±2.62 2.107±0.88

Conserved Regions

Gene is not located within a conserved region.

Gene Ontology

GO IDEvidence TypeGO Description
GO:0000320 IDA re-entry into mitotic cell cycle
GO:0001085 IEA RNA polymerase II transcription factor binding
GO:0001837 ISS epithelial to mesenchymal transition
GO:0001954 IEA positive regulation of cell-matrix adhesion
GO:0002039 IEA p53 binding
GO:0004672 IDA protein kinase activity
GO:0004674 ISS protein serine/threonine kinase activity
GO:0005178 IEA integrin binding
GO:0005515 IPI protein binding
GO:0005634 ISS nucleus
GO:0005654 TAS nucleoplasm
GO:0005737 ISS cytoplasm
GO:0005813 IEA centrosome
GO:0005829 IDA cytosol
GO:0005886 ISS plasma membrane
GO:0005977 IEA glycogen metabolic process
GO:0006349 IMP regulation of gene expression by genetic imprinting
GO:0006468 IDA protein phosphorylation
GO:0006611 IDA protein export from nucleus
GO:0006983 IDA ER overload response
GO:0007010 TAS cytoskeleton organization
GO:0007163 IEA establishment or maintenance of cell polarity
GO:0007409 IGI axonogenesis
GO:0007520 IDA myoblast fusion
GO:0007623 IMP circadian rhythm
GO:0008013 IPI beta-catenin binding
GO:0008283 TAS cell proliferation
GO:0009887 IMP organ morphogenesis
GO:0010226 IEA response to lithium ion
GO:0010614 IDA negative regulation of cardiac muscle hypertrophy
GO:0010800 IDA positive regulation of peptidyl-threonine phosphorylation
GO:0010975 IGI regulation of neuron projection development
GO:0010977 IGI negative regulation of neuron projection development
GO:0014043 IGI negative regulation of neuron maturation
GO:0014902 IGI myotube differentiation
GO:0016020 ISS membrane
GO:0016055 IGI Wnt signaling pathway
GO:0016301 ISS kinase activity
GO:0016310 IMP phosphorylation
GO:0016477 IGI cell migration
GO:0018105 IDA peptidyl-serine phosphorylation
GO:0019901 IEA protein kinase binding
GO:0021766 IEA hippocampus development
GO:0030010 IEA establishment of cell polarity
GO:0030426 IDA growth cone
GO:0030529 IDA ribonucleoprotein complex
GO:0030877 IDA beta-catenin destruction complex
GO:0031333 IEA negative regulation of protein complex assembly
GO:0031334 IEA positive regulation of protein complex assembly
GO:0031625 IEA ubiquitin protein ligase binding
GO:0032091 IEA negative regulation of protein binding
GO:0032092 IDA positive regulation of protein binding
GO:0032436 IGI positive regulation of proteasomal ubiquitin-dependent protein catabolic process
GO:0032855 IEA positive regulation of Rac GTPase activity
GO:0032886 IDA regulation of microtubule-based process
GO:0033138 IDA positive regulation of peptidyl-serine phosphorylation
GO:0034236 IEA protein kinase A catalytic subunit binding
GO:0035255 IEA ionotropic glutamate receptor binding
GO:0035372 IGI protein localization to microtubule
GO:0035556 ISO intracellular signal transduction
GO:0036016 IDA cellular response to interleukin-3
GO:0042493 IEA response to drug
GO:0043025 IDA neuronal cell body
GO:0043065 IEA positive regulation of apoptotic process
GO:0043066 IMP negative regulation of apoptotic process
GO:0043197 IEA dendritic spine
GO:0043198 IDA dendritic shaft
GO:0043227 IDA membrane-bounded organelle
GO:0043234 IEA protein complex
GO:0043407 IEA negative regulation of MAP kinase activity
GO:0044027 IMP hypermethylation of CpG island
GO:0044297 IDA cell body
GO:0044337 IMP canonical Wnt signaling pathway involved in positive regulation of apoptotic process
GO:0045121 IEA membrane raft
GO:0045444 IDA fat cell differentiation
GO:0045773 IGI positive regulation of axon extension
GO:0045944 IMP positive regulation of transcription from RNA polymerase II promoter
GO:0046827 IEA positive regulation of protein export from nucleus
GO:0048156 IEA tau protein binding
GO:0048168 IEA regulation of neuronal synaptic plasticity
GO:0048471 IDA perinuclear region of cytoplasm
GO:0050321 IDA tau-protein kinase activity
GO:0050774 IEA negative regulation of dendrite morphogenesis
GO:0051059 IEA NF-kappaB binding
GO:0051534 ISS negative regulation of NFAT protein import into nucleus
GO:0060070 IDA canonical Wnt signaling pathway
GO:0071109 IEA superior temporal gyrus development
GO:0071260 IEA cellular response to mechanical stimulus
GO:0097192 IDA extrinsic apoptotic signaling pathway in absence of ligand
GO:1901030 IDA positive regulation of mitochondrial outer membrane permeabilization involved in apoptotic signaling pathway
GO:2000738 IMP positive regulation of stem cell differentiation

Homologs

ENSEMBL Accession Gene Name Biotype Species E-Value Bit Score
ENST00000264235 GSK3B-001 protein_coding Homo_sapiens 0 3223
ENST00000316626 GSK3B-002 protein_coding Homo_sapiens 0 1550
ENST00000473886 GSK3B-004 processed_transcript Homo_sapiens 0 425
ENST00000474830 GSK3B-003 retained_intron Homo_sapiens 0 333

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