C-It-Loci: A knowledge database for tissue-enriched loci.

Institute of Cardiovascular Regeneration, Goethe-University Frankfurt am Main

Transcript Info
Description: glycogen synthase kinase 3 beta
Transcript Accession Transcript Name Contained in Gene Tax ID Strand Position Biotype
ENST00000264235 GSK3B-001 ENSG00000082701 9606 - 3:119821323-120094417 protein_coding

Expression Patterns

Heat Map
Numeric Values
Transcript'; AdiposeAdrenalBladderBrainBreastColonHeartKidneyLiverLungMuscleOvaryPlacentaTestisENST00000264235
Transcript ID Adipose Adrenal Bladder Brain Breast Colon Heart Kidney Liver Lung Muscle Ovary Placenta Testis
ENST00000264235 6.787±0.00 3.767±0.00 2.229±0.00 9.058±1.71 4.789±1.53 3.502±0.64 3.586±2.76 3.392±0.00 2.275±1.04 4.021±1.13 5.050±0.00 3.482±0.84 4.002±0.09 4.235±1.28

Conserved Regions

Region IDSub-RegionRegion TypePosition
CIL_0005BP CIL_0005BP_0002 CGP 3:119780484-120094417
CIL_0002U6 CIL_0002U6_0002 CGP 3:119821323-120285094

Gene Ontology

GO IDEvidence TypeGO Description
GO:0001085 IPI RNA polymerase II transcription factor binding
GO:0001837 IMP epithelial to mesenchymal transition
GO:0001954 IMP positive regulation of cell-matrix adhesion
GO:0002039 IDA p53 binding
GO:0004672 IEA protein kinase activity
GO:0004674 ISS protein serine/threonine kinase activity
GO:0004713 IEA protein tyrosine kinase activity
GO:0005515 IPI protein binding
GO:0005524 IEA ATP binding
GO:0005634 IDA nucleus
GO:0005737 IDA cytoplasm
GO:0005813 IDA centrosome
GO:0005829 TAS cytosol
GO:0005886 IDA plasma membrane
GO:0005977 IDA glycogen metabolic process
GO:0006468 IDA:IEA protein phosphorylation
GO:0006983 IDA ER overload response
GO:0007173 TAS epidermal growth factor receptor signaling pathway
GO:0007411 TAS axon guidance
GO:0007623 ISS circadian rhythm
GO:0008013 IPI beta-catenin binding
GO:0008543 TAS fibroblast growth factor receptor signaling pathway
GO:0016301 IDA kinase activity
GO:0016772 IEA transferase activity, transferring phosphorus-containing groups
GO:0018105 IDA peptidyl-serine phosphorylation
GO:0019901 IPI protein kinase binding
GO:0021766 IMP hippocampus development
GO:0030877 IDA beta-catenin destruction complex
GO:0031333 IMP negative regulation of protein complex assembly
GO:0031334 IDA positive regulation of protein complex assembly
GO:0031625 IPI ubiquitin protein ligase binding
GO:0032091 IDA negative regulation of protein binding
GO:0032092 ISS positive regulation of protein binding
GO:0032855 IMP positive regulation of Rac GTPase activity
GO:0032886 IMP regulation of microtubule-based process
GO:0034236 IPI protein kinase A catalytic subunit binding
GO:0035556 IDA intracellular signal transduction
GO:0036016 ISS cellular response to interleukin-3
GO:0038095 TAS Fc-epsilon receptor signaling pathway
GO:0043066 IDA negative regulation of apoptotic process
GO:0045087 TAS innate immune response
GO:0045719 TAS negative regulation of glycogen biosynthetic process
GO:0045732 IC positive regulation of protein catabolic process
GO:0046827 IDA positive regulation of protein export from nucleus
GO:0048011 TAS neurotrophin TRK receptor signaling pathway
GO:0048015 TAS phosphatidylinositol-mediated signaling
GO:0050321 IDA tau-protein kinase activity
GO:0051059 IPI NF-kappaB binding
GO:0051534 IMP negative regulation of NFAT protein import into nucleus
GO:0060070 IDA canonical Wnt signaling pathway
GO:0071109 IMP superior temporal gyrus development
GO:0090090 TAS negative regulation of canonical Wnt signaling pathway
GO:0097192 ISS extrinsic apoptotic signaling pathway in absence of ligand
GO:1901030 ISS positive regulation of mitochondrial outer membrane permeabilization involved in apoptotic signaling pathway
GO:2000077 TAS negative regulation of type B pancreatic cell development
GO:2000466 TAS negative regulation of glycogen (starch) synthase activity

Homologs

ENSEMBL Accession Gene Name Biotype Species E-Value Bit Score
ENSMUST00000023507 Gsk3b-001 protein_coding Mus_musculus 0 3223
ENSMUST00000114750 Gsk3b-003 protein_coding Mus_musculus 0 1550
ENSMUST00000132057 Gsk3b-002 retained_intron Mus_musculus 0 1168
ENSMUST00000134870 Gsk3b-004 processed_transcript Mus_musculus 0 920

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