C-It-Loci: A knowledge database for tissue-enriched loci.

Institute of Cardiovascular Regeneration, Goethe-University Frankfurt am Main

Transcript Info
Description: notch 1
Transcript Accession Transcript Name Contained in Gene Tax ID Strand Position Biotype
ENSMUST00000028288 Notch1-001 ENSMUSG00000026923 10090 - 2:26457903-26503822 protein_coding

Expression Patterns

Heat Map
Numeric Values
Transcript'; AdiposeAdrenalBladderBrainBreastColonHeartKidneyLiverLungMuscleOvaryPlacentaTestisENSMUST00000028288
Transcript ID Adipose Adrenal Bladder Brain Breast Colon Heart Kidney Liver Lung Muscle Ovary Placenta Testis
ENSMUST00000028288 14.829±1.16 8.736±0.66 8.603±1.08 18.817±17.89 19.126±8.24 9.506±1.44 7.047±0.93 6.078±0.55 2.070±0.85 36.942±11.56 1.534±0.31 12.041±4.48 1.662±0.57 1.472±0.14

Conserved Regions

Region IDSub-RegionRegion TypePosition
CIL_0003X5 CIL_0003X5_0002 CGP 2:26457903-26593120

Gene Ontology

GO IDEvidence TypeGO Description
GO:0000122 IDA negative regulation of transcription from RNA polymerase II promoter
GO:0000139 TAS Golgi membrane
GO:0001047 IDA core promoter binding
GO:0001190 IDA RNA polymerase II transcription factor binding transcription factor activity involved in positive regulation of transcription
GO:0001669 IEA acrosomal vesicle
GO:0001701 IMP in utero embryonic development
GO:0001708 IMP cell fate specification
GO:0001726 ISS ruffle
GO:0001837 IMP epithelial to mesenchymal transition
GO:0001889 IMP liver development
GO:0001947 IGI heart looping
GO:0002040 IMP sprouting angiogenesis
GO:0002051 NAS osteoblast fate commitment
GO:0002052 IEA positive regulation of neuroblast proliferation
GO:0002193 IEA MAML1-RBP-Jkappa- ICN1 complex
GO:0002437 IGI inflammatory response to antigenic stimulus
GO:0003157 IMP endocardium development
GO:0003160 IEP endocardium morphogenesis
GO:0003162 IMP atrioventricular node development
GO:0003169 IMP coronary vein morphogenesis
GO:0003180 ISS aortic valve morphogenesis
GO:0003181 IMP atrioventricular valve morphogenesis
GO:0003184 IEA pulmonary valve morphogenesis
GO:0003192 IEA mitral valve formation
GO:0003198 IMP epithelial to mesenchymal transition involved in endocardial cushion formation
GO:0003203 IMP endocardial cushion morphogenesis
GO:0003207 IMP cardiac chamber formation
GO:0003208 IMP cardiac ventricle morphogenesis
GO:0003209 IMP cardiac atrium morphogenesis
GO:0003213 IMP cardiac right atrium morphogenesis
GO:0003214 IMP cardiac left ventricle morphogenesis
GO:0003219 IMP cardiac right ventricle formation
GO:0003222 IMP ventricular trabecula myocardium morphogenesis
GO:0003241 IMP growth involved in heart morphogenesis
GO:0003256 IMP regulation of transcription from RNA polymerase II promoter involved in myocardial precursor cell differentiation
GO:0003264 IEA regulation of cardioblast proliferation
GO:0003270 IMP Notch signaling pathway involved in regulation of secondary heart field cardioblast proliferation
GO:0003273 IMP cell migration involved in endocardial cushion formation
GO:0003344 IMP pericardium morphogenesis
GO:0003682 IDA chromatin binding
GO:0003700 IDA sequence-specific DNA binding transcription factor activity
GO:0004857 IDA enzyme inhibitor activity
GO:0004872 IEA receptor activity
GO:0005509 IEA calcium ion binding
GO:0005515 IPI protein binding
GO:0005576 TAS extracellular region
GO:0005634 IDA nucleus
GO:0005654 TAS nucleoplasm
GO:0005737 IDA cytoplasm
GO:0005789 TAS endoplasmic reticulum membrane
GO:0005794 IEA Golgi apparatus
GO:0005829 TAS cytosol
GO:0005856 ISS cytoskeleton
GO:0005886 IDA plasma membrane
GO:0005887 IC integral component of plasma membrane
GO:0006351 IEA transcription, DNA-templated
GO:0006357 IGI regulation of transcription from RNA polymerase II promoter
GO:0006959 IGI humoral immune response
GO:0007219 IC Notch signaling pathway
GO:0007221 IGI positive regulation of transcription of Notch receptor target
GO:0007283 IEA spermatogenesis
GO:0007368 IMP determination of left/right symmetry
GO:0007386 IMP compartment pattern specification
GO:0007409 IDA axonogenesis
GO:0007420 IEA brain development
GO:0007440 IMP foregut morphogenesis
GO:0007492 IMP endoderm development
GO:0007507 IMP heart development
GO:0008284 IGI positive regulation of cell proliferation
GO:0008285 ISS negative regulation of cell proliferation
GO:0008544 IGI epidermis development
GO:0009912 IMP auditory receptor cell fate commitment
GO:0009986 IDA cell surface
GO:0010001 IMP glial cell differentiation
GO:0010468 IMP regulation of gene expression
GO:0010718 IMP positive regulation of epithelial to mesenchymal transition
GO:0010812 IEA negative regulation of cell-substrate adhesion
GO:0010832 IDA negative regulation of myotube differentiation
GO:0014031 IMP mesenchymal cell development
GO:0014807 IMP regulation of somitogenesis
GO:0019899 IPI enzyme binding
GO:0021515 IEA cell differentiation in spinal cord
GO:0021915 IMP neural tube development
GO:0030027 ISS lamellipodium
GO:0030154 IMP cell differentiation
GO:0030182 IMP neuron differentiation
GO:0030216 IMP keratinocyte differentiation
GO:0030279 IMP negative regulation of ossification
GO:0030324 IMP lung development
GO:0030326 IGI embryonic limb morphogenesis
GO:0030334 IMP regulation of cell migration
GO:0030335 IMP positive regulation of cell migration
GO:0030513 IDA positive regulation of BMP signaling pathway
GO:0030514 IMP negative regulation of BMP signaling pathway
GO:0030900 IGI forebrain development
GO:0031069 IMP hair follicle morphogenesis
GO:0031100 IEA organ regeneration
GO:0031490 IDA chromatin DNA binding
GO:0031960 IEA response to corticosteroid
GO:0032495 IDA response to muramyl dipeptide
GO:0032496 IEA response to lipopolysaccharide
GO:0035116 IMP embryonic hindlimb morphogenesis
GO:0035148 ISS tube formation
GO:0035914 IMP skeletal muscle cell differentiation
GO:0035924 ISS cellular response to vascular endothelial growth factor stimulus
GO:0042127 IEA regulation of cell proliferation
GO:0042246 IEA tissue regeneration
GO:0043065 IDA positive regulation of apoptotic process
GO:0043086 IDA negative regulation of catalytic activity
GO:0043235 ISO receptor complex
GO:0043565 IDA sequence-specific DNA binding
GO:0045165 IMP cell fate commitment
GO:0045596 IMP negative regulation of cell differentiation
GO:0045603 IEA positive regulation of endothelial cell differentiation
GO:0045618 IGI positive regulation of keratinocyte differentiation
GO:0045662 IEA negative regulation of myoblast differentiation
GO:0045665 IGI negative regulation of neuron differentiation
GO:0045668 IMP negative regulation of osteoblast differentiation
GO:0045687 IEA positive regulation of glial cell differentiation
GO:0045892 IDA negative regulation of transcription, DNA-templated
GO:0045893 IDA positive regulation of transcription, DNA-templated
GO:0045944 IDA positive regulation of transcription from RNA polymerase II promoter
GO:0045955 IMP negative regulation of calcium ion-dependent exocytosis
GO:0046427 IDA positive regulation of JAK-STAT cascade
GO:0046533 IMP negative regulation of photoreceptor cell differentiation
GO:0048103 IDA somatic stem cell division
GO:0048663 IGI neuron fate commitment
GO:0048708 IEA astrocyte differentiation
GO:0048709 IEA oligodendrocyte differentiation
GO:0048711 IDA positive regulation of astrocyte differentiation
GO:0048715 IDA negative regulation of oligodendrocyte differentiation
GO:0048754 IMP branching morphogenesis of an epithelial tube
GO:0050678 IMP regulation of epithelial cell proliferation
GO:0050679 IGI positive regulation of epithelial cell proliferation
GO:0050767 IMP regulation of neurogenesis
GO:0050768 IDA negative regulation of neurogenesis
GO:0055008 IMP cardiac muscle tissue morphogenesis
GO:0060038 IMP cardiac muscle cell proliferation
GO:0060045 IMP positive regulation of cardiac muscle cell proliferation
GO:0060253 IDA negative regulation of glial cell proliferation
GO:0060271 ISS cilium morphogenesis
GO:0060317 IMP cardiac epithelial to mesenchymal transition
GO:0060411 IMP cardiac septum morphogenesis
GO:0060412 IEA ventricular septum morphogenesis
GO:0060528 IMP secretory columnal luminar epithelial cell differentiation involved in prostate glandular acinus development
GO:0060548 IMP negative regulation of cell death
GO:0060740 IMP prostate gland epithelium morphogenesis
GO:0060768 IMP regulation of epithelial cell proliferation involved in prostate gland development
GO:0060842 IMP arterial endothelial cell differentiation
GO:0060843 IMP venous endothelial cell differentiation
GO:0060948 IMP cardiac vascular smooth muscle cell development
GO:0060956 IMP endocardial cell differentiation
GO:0060979 IMP vasculogenesis involved in coronary vascular morphogenesis
GO:0060982 IMP coronary artery morphogenesis
GO:0061314 IMP Notch signaling involved in heart development
GO:0061344 IC regulation of cell adhesion involved in heart morphogenesis
GO:0061384 IMP heart trabecula morphogenesis
GO:0061419 IDA positive regulation of transcription from RNA polymerase II promoter in response to hypoxia
GO:0070986 IGI left/right axis specification
GO:0071372 IEA cellular response to follicle-stimulating hormone stimulus
GO:0071944 IDA cell periphery
GO:0072017 IEP distal tubule development
GO:0072044 IEP collecting duct development
GO:0072144 IEP glomerular mesangial cell development
GO:0072602 IGI interleukin-4 secretion
GO:0090051 ISS negative regulation of cell migration involved in sprouting angiogenesis
GO:0090090 IMP negative regulation of canonical Wnt signaling pathway
GO:0097150 IEA neuronal stem cell maintenance
GO:1901189 IC positive regulation of ephrin receptor signaling pathway
GO:1901201 IMP regulation of extracellular matrix assembly
GO:1902263 IMP apoptotic process involved in embryonic digit morphogenesis
GO:2000737 IEA negative regulation of stem cell differentiation
GO:2000811 IEA negative regulation of anoikis
GO:2000974 IMP negative regulation of pro-B cell differentiation
GO:2001027 ISS negative regulation of endothelial cell chemotaxis

Homologs

ENSEMBL Accession Gene Name Biotype Species E-Value Bit Score
ENSDART00000130888 notch1b-001 protein_coding Danio_rerio 0 1515
ENSDART00000050855 notch1b-201 protein_coding Danio_rerio 0 584
ENSDART00000050858 notch1a-204 protein_coding Danio_rerio 0 372
ENST00000277541 NOTCH1-001 protein_coding Homo_sapiens 0 5373
ENST00000494783 NOTCH1-002 processed_transcript Homo_sapiens 0 219

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