C-It-Loci: A knowledge database for tissue-enriched loci.

Institute of Cardiovascular Regeneration, Goethe-University Frankfurt am Main

Transcript Info
Description: cyclin-dependent kinase 5
Transcript Accession Transcript Name Contained in Gene Tax ID Strand Position Biotype
ENSMUST00000030814 Cdk5-201 ENSMUSG00000028969 10090 - 5:24418250-24423530 protein_coding

Expression Patterns

Heat Map
Numeric Values
Transcript'; AdiposeAdrenalBladderBrainBreastColonHeartKidneyLiverLungMuscleOvaryPlacentaTestisENSMUST00000030814
Transcript ID Adipose Adrenal Bladder Brain Breast Colon Heart Kidney Liver Lung Muscle Ovary Placenta Testis
ENSMUST00000030814 23.717±6.08 26.023±2.89 20.017±0.43 47.212±9.94 19.850±2.57 17.954±6.17 7.784±2.43 19.623±7.32 10.119±1.81 14.447±5.44 4.099±0.53 29.934±9.30 18.952±4.08 14.270±5.65

Conserved Regions

Region IDSub-RegionRegion TypePosition
CIL_0008T1 CIL_0008T1_0002 VISTA 5:24041638-24646055
CIL_0004ET CIL_0004ET_0002 CGP 5:24413451-24423530
CIL_0004ES CIL_0004ES_0002 CGP 5:24418250-24440950

Gene Ontology

GO IDEvidence TypeGO Description
GO:0001764 IMP neuron migration
GO:0001963 IMP synaptic transmission, dopaminergic
GO:0002039 IPI p53 binding
GO:0004672 IDA protein kinase activity
GO:0004674 ISS protein serine/threonine kinase activity
GO:0004693 ISS cyclin-dependent protein serine/threonine kinase activity
GO:0005176 IDA ErbB-2 class receptor binding
GO:0005515 IPI protein binding
GO:0005524 IEA ATP binding
GO:0005634 ISS nucleus
GO:0005737 ISS cytoplasm
GO:0005829 IDA cytosol
GO:0005856 IEA cytoskeleton
GO:0006468 IDA protein phosphorylation
GO:0006886 IMP intracellular protein transport
GO:0006887 IEA exocytosis
GO:0006913 IEA nucleocytoplasmic transport
GO:0006915 IDA apoptotic process
GO:0007049 IEA cell cycle
GO:0007160 IDA cell-matrix adhesion
GO:0007409 IMP axonogenesis
GO:0007416 IMP synapse assembly
GO:0007519 IDA skeletal muscle tissue development
GO:0008045 IMP motor neuron axon guidance
GO:0008092 IEA cytoskeletal protein binding
GO:0008306 IMP associative learning
GO:0008542 IMP visual learning
GO:0009611 IEA response to wounding
GO:0009790 ISS embryo development
GO:0014044 IMP Schwann cell development
GO:0014069 ISS postsynaptic density
GO:0016020 ISS membrane
GO:0016301 ISS kinase activity
GO:0016310 IEA phosphorylation
GO:0016477 IDA cell migration
GO:0016533 IEA cyclin-dependent protein kinase 5 holoenzyme complex
GO:0018105 IDA peptidyl-serine phosphorylation
GO:0018107 IDA peptidyl-threonine phosphorylation
GO:0019233 IMP sensory perception of pain
GO:0021537 IMP telencephalon development
GO:0021549 IMP cerebellum development
GO:0021695 IMP cerebellar cortex development
GO:0021697 IMP cerebellar cortex formation
GO:0021766 IMP hippocampus development
GO:0021819 IMP layer formation in cerebral cortex
GO:0021954 IMP central nervous system neuron development
GO:0021987 IMP cerebral cortex development
GO:0022038 IMP corpus callosum development
GO:0030027 IDA lamellipodium
GO:0030054 IEA cell junction
GO:0030175 IDA filopodium
GO:0030182 ISS neuron differentiation
GO:0030334 IMP regulation of cell migration
GO:0030424 ISS axon
GO:0030425 ISS dendrite
GO:0030426 ISS growth cone
GO:0030517 IGI negative regulation of axon extension
GO:0030549 IDA acetylcholine receptor activator activity
GO:0030866 IEA cortical actin cytoskeleton organization
GO:0030900 IMP forebrain development
GO:0031175 ISS neuron projection development
GO:0031397 IMP negative regulation of protein ubiquitination
GO:0031594 ISS neuromuscular junction
GO:0031914 IMP negative regulation of synaptic plasticity
GO:0032092 IMP positive regulation of protein binding
GO:0032801 IMP receptor catabolic process
GO:0033136 IDA serine phosphorylation of STAT3 protein
GO:0035249 IMP synaptic transmission, glutamatergic
GO:0035418 IMP protein localization to synapse
GO:0042220 IMP response to cocaine
GO:0043025 ISS neuronal cell body
GO:0043113 IMP receptor clustering
GO:0043125 IDA ErbB-3 class receptor binding
GO:0043525 ISS positive regulation of neuron apoptotic process
GO:0045055 IEA regulated secretory pathway
GO:0045211 IEA postsynaptic membrane
GO:0045786 IMP negative regulation of cell cycle
GO:0045860 IMP positive regulation of protein kinase activity
GO:0045861 IEA negative regulation of proteolysis
GO:0045892 IEA negative regulation of transcription, DNA-templated
GO:0045956 IDA positive regulation of calcium ion-dependent exocytosis
GO:0046777 IEA protein autophosphorylation
GO:0046826 IMP negative regulation of protein export from nucleus
GO:0046875 IEA ephrin receptor binding
GO:0048148 IMP behavioral response to cocaine
GO:0048167 ISS regulation of synaptic plasticity
GO:0048488 IEA synaptic vesicle endocytosis
GO:0048511 IEA rhythmic process
GO:0048709 IEA oligodendrocyte differentiation
GO:0048812 IEA neuron projection morphogenesis
GO:0048813 IMP dendrite morphogenesis
GO:0050321 ISS tau-protein kinase activity
GO:0051301 IEA cell division
GO:0051402 IMP neuron apoptotic process
GO:0060078 IMP regulation of postsynaptic membrane potential
GO:0060079 IMP regulation of excitatory postsynaptic membrane potential
GO:0061001 IMP regulation of dendritic spine morphogenesis
GO:0070509 IMP calcium ion import
GO:0090314 IMP positive regulation of protein targeting to membrane
GO:1901215 IEA negative regulation of neuron death
GO:2000273 IDA positive regulation of receptor activity

Homologs

ENSEMBL Accession Gene Name Biotype Species E-Value Bit Score
ENST00000297518 CDK5-003 protein_coding Homo_sapiens 0 634
ENST00000360066 CDK18-001 protein_coding Homo_sapiens 0.000000000003 79
ENST00000429964 CDK18-003 protein_coding Homo_sapiens 0.000000000002 79
ENST00000442838 CDK5PS-001 processed_pseudogene Homo_sapiens 0 968
ENST00000469108 CDK5-005 retained_intron Homo_sapiens 0 333
ENST00000485972 CDK5-001 protein_coding Homo_sapiens 0 1352
ENST00000487703 CDK5-004 retained_intron Homo_sapiens 0 726
ENST00000489617 CDK18-002 retained_intron Homo_sapiens 0.000000000003 79
ENST00000504648 CDK18-013 nonsense_mediated_decay Homo_sapiens 0.000000000003 79
ENST00000505932 CDK18-018 processed_transcript Homo_sapiens 0.000000000002 79
ENST00000506489 CDK18-021 processed_transcript Homo_sapiens 0.000000000007 75
ENST00000506784 CDK18-006 protein_coding Homo_sapiens 0.000000000002 79
ENST00000515494 CDK18-017 nonsense_mediated_decay Homo_sapiens 0.000000000004 79
ENST00000618146 CDK5-201 protein_coding Homo_sapiens 0 1352

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