C-It-Loci: A knowledge database for tissue-enriched loci.

Institute of Cardiovascular Regeneration, Goethe-University Frankfurt am Main

Transcript Info
Description: insulin-like growth factor 1
Transcript Accession Transcript Name Contained in Gene Tax ID Strand Position Biotype
ENSMUST00000062862 Igf1-002 ENSMUSG00000020053 10090 + 10:87860030-87915894 protein_coding

Expression Patterns

Heat Map
Numeric Values
Transcript'; AdrenalBreastColonOvaryENSMUST00000062862
Transcript ID Adrenal Breast Colon Ovary
ENSMUST00000062862 1.123±0.30 4.749±0.00 0.284±0.00 3.042±0.29

Conserved Regions

Region IDSub-RegionRegion TypePosition
CIL_0008WS CIL_0008WS_0002 VISTA 10:87568234-88170738

Gene Ontology

GO IDEvidence TypeGO Description
GO:0001775 ISO cell activation
GO:0001932 IDA regulation of protein phosphorylation
GO:0001974 IGI blood vessel remodeling
GO:0005158 IEA insulin receptor binding
GO:0005159 IPI insulin-like growth factor receptor binding
GO:0005178 IEA integrin binding
GO:0005515 IPI protein binding
GO:0005615 IDA extracellular space
GO:0007399 IMP nervous system development
GO:0008083 IEA growth factor activity
GO:0008284 IGI positive regulation of cell proliferation
GO:0008285 IGI negative regulation of cell proliferation
GO:0010001 IMP glial cell differentiation
GO:0010613 IEA positive regulation of cardiac muscle hypertrophy
GO:0014068 IDA positive regulation of phosphatidylinositol 3-kinase signaling
GO:0014834 IEA skeletal muscle satellite cell maintenance involved in skeletal muscle regeneration
GO:0014896 IEA muscle hypertrophy
GO:0014904 IEA myotube cell development
GO:0014911 IEA positive regulation of smooth muscle cell migration
GO:0021940 IDA positive regulation of cerebellar granule cell precursor proliferation
GO:0030104 IGI water homeostasis
GO:0030166 IEA proteoglycan biosynthetic process
GO:0030324 IGI lung development
GO:0030879 IMP mammary gland development
GO:0031017 IMP exocrine pancreas development
GO:0032878 IDA regulation of establishment or maintenance of cell polarity
GO:0033160 IEA positive regulation of protein import into nucleus, translocation
GO:0034392 IEA negative regulation of smooth muscle cell apoptotic process
GO:0035264 IDA multicellular organism growth
GO:0035630 IEA bone mineralization involved in bone maturation
GO:0040014 IEA regulation of multicellular organism growth
GO:0042104 IEA positive regulation of activated T cell proliferation
GO:0042523 IEA positive regulation of tyrosine phosphorylation of Stat5 protein
GO:0043066 IDA negative regulation of apoptotic process
GO:0043388 IEA positive regulation of DNA binding
GO:0043410 IEA positive regulation of MAPK cascade
GO:0043568 IEA positive regulation of insulin-like growth factor receptor signaling pathway
GO:0045445 IEA myoblast differentiation
GO:0045669 IEA positive regulation of osteoblast differentiation
GO:0045725 IEA positive regulation of glycogen biosynthetic process
GO:0045821 IEA positive regulation of glycolytic process
GO:0045840 IEA positive regulation of mitosis
GO:0045893 IEA positive regulation of transcription, DNA-templated
GO:0045944 IDA positive regulation of transcription from RNA polymerase II promoter
GO:0046326 IEA positive regulation of glucose import
GO:0046579 IEA positive regulation of Ras protein signal transduction
GO:0048009 IDA insulin-like growth factor receptor signaling pathway
GO:0048015 IEA phosphatidylinositol-mediated signaling
GO:0048146 IEA positive regulation of fibroblast proliferation
GO:0048286 IGI lung alveolus development
GO:0048468 IMP cell development
GO:0048661 IEA positive regulation of smooth muscle cell proliferation
GO:0048754 IMP branching morphogenesis of an epithelial tube
GO:0048839 IDA inner ear development
GO:0050650 IDA chondroitin sulfate proteoglycan biosynthetic process
GO:0050679 IEA positive regulation of epithelial cell proliferation
GO:0050731 IEA positive regulation of peptidyl-tyrosine phosphorylation
GO:0051246 IGI regulation of protein metabolic process
GO:0051450 IEA myoblast proliferation
GO:0051897 IDA positive regulation of protein kinase B signaling
GO:0060426 IGI lung vasculature development
GO:0060463 IGI lung lobe morphogenesis
GO:0060509 IMP Type I pneumocyte differentiation
GO:0060510 IMP Type II pneumocyte differentiation
GO:0060527 IMP prostate epithelial cord arborization involved in prostate glandular acinus morphogenesis
GO:0060736 IDA prostate gland growth
GO:0060740 IMP prostate gland epithelium morphogenesis
GO:0060741 IMP prostate gland stromal morphogenesis
GO:0060766 IMP negative regulation of androgen receptor signaling pathway
GO:0070373 IGI negative regulation of ERK1 and ERK2 cascade
GO:0070886 IEA positive regulation of calcineurin-NFAT signaling cascade
GO:0097192 IDA extrinsic apoptotic signaling pathway in absence of ligand
GO:2000288 IMP positive regulation of myoblast proliferation
GO:2001237 IEA negative regulation of extrinsic apoptotic signaling pathway

Homologs

ENSEMBL Accession Gene Name Biotype Species E-Value Bit Score
ENST00000307046 IGF1-002 protein_coding Homo_sapiens 0 483
ENST00000337514 IGF1-001 protein_coding Homo_sapiens 0 411
ENST00000392904 IGF1-005 protein_coding Homo_sapiens 0 433
ENST00000392905 IGF1-003 protein_coding Homo_sapiens 0 433
ENST00000424202 IGF1-004 protein_coding Homo_sapiens 0 582
ENST00000456098 IGF1-201 protein_coding Homo_sapiens 0 433

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