C-It-Loci: A knowledge database for tissue-enriched loci.

Institute of Cardiovascular Regeneration, Goethe-University Frankfurt am Main

Transcript Info
Description: G protein-coupled estrogen receptor 1
Transcript Accession Transcript Name Contained in Gene Tax ID Strand Position Biotype
ENSMUST00000066211 Gper1-001 ENSMUSG00000053647 10090 + 5:139423151-139427800 protein_coding

Expression Patterns

Heat Map
Numeric Values
Transcript'; AdiposeAdrenalBladderBrainBreastColonHeartKidneyLiverLungMuscleOvaryPlacentaTestisENSMUST00000066211
Transcript ID Adipose Adrenal Bladder Brain Breast Colon Heart Kidney Liver Lung Muscle Ovary Placenta Testis
ENSMUST00000066211 1.634±0.62 2.281±0.66 0.452±0.05 1.592±0.53 0.811±0.27 1.058±0.26 0.716±0.13 0.949±0.23 0.050±0.04 0.733±0.22 0.458±0.16 1.190±0.51 0.062±0.02 0.090±0.02

Conserved Regions

Region IDSub-RegionRegion TypePosition
CIL_0008V5 CIL_0008V5_0002 VISTA 5:139236245-139837428
CIL_0008DL CIL_0008DL_0002 VISTA 5:139238772-139840184
CIL_0000ZU CIL_0000ZU_0002 CGP 5:139352617-139460502
CIL_0000ZR CIL_0000ZR_0002 CGP 5:139359739-139460502
CIL_0000ZS CIL_0000ZS_0002 CGP 5:139423151-139484549

Gene Ontology

GO IDEvidence TypeGO Description
GO:0001934 ISS positive regulation of protein phosphorylation
GO:0001956 ISS positive regulation of neurotransmitter secretion
GO:0002695 ISS negative regulation of leukocyte activation
GO:0003682 IEA chromatin binding
GO:0004930 IEA G-protein coupled receptor activity
GO:0005496 ISS steroid binding
GO:0005515 IEA protein binding
GO:0005622 IDA intracellular
GO:0005634 ISS nucleus
GO:0005635 ISS nuclear envelope
GO:0005737 IDA cytoplasm
GO:0005769 ISS early endosome
GO:0005783 ISS endoplasmic reticulum
GO:0005794 ISS Golgi apparatus
GO:0005802 ISS trans-Golgi network
GO:0005886 ISS plasma membrane
GO:0006954 IEA inflammatory response
GO:0007049 IEA cell cycle
GO:0007204 IDA positive regulation of cytosolic calcium ion concentration
GO:0008284 ISS positive regulation of cell proliferation
GO:0008285 ISS negative regulation of cell proliferation
GO:0010579 ISS positive regulation of adenylate cyclase activity involved in G-protein coupled receptor signaling pathway
GO:0010628 ISS positive regulation of gene expression
GO:0010629 ISS negative regulation of gene expression
GO:0014068 ISS positive regulation of phosphatidylinositol 3-kinase signaling
GO:0014069 ISS postsynaptic density
GO:0016021 IEA integral component of membrane
GO:0017082 ISS mineralocorticoid receptor activity
GO:0019228 ISS neuronal action potential
GO:0030054 IEA cell junction
GO:0030263 ISS apoptotic chromosome condensation
GO:0030264 ISS nuclear fragmentation involved in apoptotic nuclear change
GO:0030284 ISS estrogen receptor activity
GO:0030335 ISS positive regulation of cell migration
GO:0030424 ISS axon
GO:0030425 ISS dendrite
GO:0030518 ISS intracellular steroid hormone receptor signaling pathway
GO:0030659 ISS cytoplasmic vesicle membrane
GO:0030819 ISS positive regulation of cAMP biosynthetic process
GO:0031959 ISS mineralocorticoid receptor signaling pathway
GO:0031966 ISS mitochondrial membrane
GO:0032024 IDA positive regulation of insulin secretion
GO:0032591 ISS dendritic spine membrane
GO:0032962 ISS positive regulation of inositol trisphosphate biosynthetic process
GO:0042734 ISS presynaptic membrane
GO:0043065 ISS positive regulation of apoptotic process
GO:0043198 ISS dendritic shaft
GO:0043280 ISS positive regulation of cysteine-type endopeptidase activity involved in apoptotic process
GO:0043401 IEA steroid hormone mediated signaling pathway
GO:0043410 IDA positive regulation of MAPK cascade
GO:0043679 ISS axon terminus
GO:0044327 ISS dendritic spine head
GO:0045087 IEA innate immune response
GO:0045095 ISS keratin filament
GO:0045211 IEA postsynaptic membrane
GO:0045599 IDA negative regulation of fat cell differentiation
GO:0045742 ISS positive regulation of epidermal growth factor receptor signaling pathway
GO:0045745 ISS positive regulation of G-protein coupled receptor protein signaling pathway
GO:0045909 ISS positive regulation of vasodilation
GO:0045944 IDA positive regulation of transcription from RNA polymerase II promoter
GO:0048471 ISS perinuclear region of cytoplasm
GO:0048786 ISS presynaptic active zone
GO:0050728 ISS negative regulation of inflammatory response
GO:0050769 IDA positive regulation of neurogenesis
GO:0051053 ISS negative regulation of DNA metabolic process
GO:0051055 IDA negative regulation of lipid biosynthetic process
GO:0051281 ISS positive regulation of release of sequestered calcium ion into cytosol
GO:0051480 ISS cytosolic calcium ion homeostasis
GO:0055037 ISS recycling endosome
GO:0070374 ISS positive regulation of ERK1 and ERK2 cascade
GO:0070474 ISS positive regulation of uterine smooth muscle contraction
GO:0071157 IDA negative regulation of cell cycle arrest
GO:0071333 IDA cellular response to glucose stimulus
GO:0071356 ISS cellular response to tumor necrosis factor
GO:0071375 ISS cellular response to peptide hormone stimulus
GO:0071389 ISS cellular response to mineralocorticoid stimulus
GO:0071392 ISS cellular response to estradiol stimulus
GO:0090004 ISS positive regulation of establishment of protein localization to plasma membrane
GO:0090200 ISS positive regulation of release of cytochrome c from mitochondria
GO:0097481 ISS neuronal postsynaptic density
GO:2000353 ISS positive regulation of endothelial cell apoptotic process
GO:2001238 ISS positive regulation of extrinsic apoptotic signaling pathway

Homologs

ENSEMBL Accession Gene Name Biotype Species E-Value Bit Score
ENST00000297469 GPER1-030 protein_coding Homo_sapiens 0 1151
ENST00000397088 GPER1-031 protein_coding Homo_sapiens 0 1151
ENST00000397092 GPER1-201 protein_coding Homo_sapiens 0 1151
ENST00000401670 GPER1-032 protein_coding Homo_sapiens 0 1151
ENST00000617001 GPER1-202 protein_coding Homo_sapiens 0 933

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