C-It-Loci: A knowledge database for tissue-enriched loci.

Institute of Cardiovascular Regeneration, Goethe-University Frankfurt am Main

Transcript Info
Description: promyelocytic leukemia
Transcript Accession Transcript Name Contained in Gene Tax ID Strand Position Biotype
ENSMUST00000085673 Pml-001 ENSMUSG00000036986 10090 - 9:58218076-58249786 protein_coding

Expression Patterns

Heat Map
Numeric Values
Transcript'; AdiposeAdrenalBladderBrainBreastColonHeartKidneyLiverLungMuscleOvaryPlacentaENSMUST00000085673
Transcript ID Adipose Adrenal Bladder Brain Breast Colon Heart Kidney Liver Lung Muscle Ovary Placenta
ENSMUST00000085673 4.559±0.77 3.399±0.00 1.122±0.00 0.434±0.05 8.459±3.20 4.434±1.15 1.083±0.19 3.093±1.57 4.375±2.42 2.926±0.89 0.155±0.01 3.691±1.41 1.559±0.82

Conserved Regions

Gene is not located within a conserved region.

Gene Ontology

GO IDEvidence TypeGO Description
GO:0001666 ISS response to hypoxia
GO:0001932 IMP regulation of protein phosphorylation
GO:0002230 IEA positive regulation of defense response to virus by host
GO:0003677 IEA DNA binding
GO:0003713 TAS transcription coactivator activity
GO:0005515 IPI protein binding
GO:0005634 IDA nucleus
GO:0005654 ISS nucleoplasm
GO:0005730 ISS nucleolus
GO:0005737 IEA cytoplasm
GO:0005768 IEA endosome
GO:0005829 IDA cytosol
GO:0006351 IEA transcription, DNA-templated
GO:0006355 IDA regulation of transcription, DNA-templated
GO:0006461 ISS protein complex assembly
GO:0006605 ISS protein targeting
GO:0006915 IEA apoptotic process
GO:0006919 IMP activation of cysteine-type endopeptidase activity involved in apoptotic process
GO:0006977 IMP DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest
GO:0007050 IMP cell cycle arrest
GO:0007179 IMP transforming growth factor beta receptor signaling pathway
GO:0007182 IMP common-partner SMAD protein phosphorylation
GO:0007184 IMP SMAD protein import into nucleus
GO:0007569 IMP cell aging
GO:0008270 IEA zinc ion binding
GO:0008285 IMP negative regulation of cell proliferation
GO:0008630 IMP intrinsic apoptotic signaling pathway in response to DNA damage
GO:0008631 IMP intrinsic apoptotic signaling pathway in response to oxidative stress
GO:0009411 IMP response to UV
GO:0010332 IMP response to gamma radiation
GO:0010522 IMP regulation of calcium ion transport into cytosol
GO:0016032 IEA viral process
GO:0016363 IDA nuclear matrix
GO:0016525 ISS negative regulation of angiogenesis
GO:0016605 IMP PML body
GO:0030099 IMP myeloid cell differentiation
GO:0030308 ISS negative regulation of cell growth
GO:0030578 IDA PML body organization
GO:0031065 ISS positive regulation of histone deacetylation
GO:0031625 IEA ubiquitin protein ligase binding
GO:0031965 IEA nuclear membrane
GO:0032183 IEA SUMO binding
GO:0032211 IEA negative regulation of telomere maintenance via telomerase
GO:0032469 IMP endoplasmic reticulum calcium ion homeostasis
GO:0032922 IDA circadian regulation of gene expression
GO:0032938 IEA negative regulation of translation in response to oxidative stress
GO:0034097 IEA response to cytokine
GO:0042406 IDA extrinsic component of endoplasmic reticulum membrane
GO:0042752 IDA regulation of circadian rhythm
GO:0042771 IMP intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator
GO:0042803 IEA protein homodimerization activity
GO:0043153 IDA entrainment of circadian clock by photoperiod
GO:0043161 ISS proteasome-mediated ubiquitin-dependent protein catabolic process
GO:0045087 IDA innate immune response
GO:0045165 IMP cell fate commitment
GO:0045343 IDA regulation of MHC class I biosynthetic process
GO:0045892 ISS negative regulation of transcription, DNA-templated
GO:0045930 IEA negative regulation of mitotic cell cycle
GO:0046332 IDA SMAD binding
GO:0046982 IEA protein heterodimerization activity
GO:0048384 IMP retinoic acid receptor signaling pathway
GO:0050821 IEA protein stabilization
GO:0050897 IEA cobalt ion binding
GO:0051457 ISO maintenance of protein location in nucleus
GO:0051607 IEA defense response to virus
GO:0051974 IEA negative regulation of telomerase activity
GO:0060058 IEA positive regulation of apoptotic process involved in mammary gland involution
GO:0060444 IMP branching involved in mammary gland duct morphogenesis
GO:0070059 IMP intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress
GO:0071353 IDA cellular response to interleukin-4
GO:0072332 IMP intrinsic apoptotic signaling pathway by p53 class mediator
GO:0090398 ISS cellular senescence
GO:0097191 IMP extrinsic apoptotic signaling pathway
GO:1902187 IDA negative regulation of viral release from host cell
GO:2000059 IEA negative regulation of protein ubiquitination involved in ubiquitin-dependent protein catabolic process
GO:2000779 ISS regulation of double-strand break repair
GO:2001235 IGI positive regulation of apoptotic signaling pathway
GO:2001238 IEA positive regulation of extrinsic apoptotic signaling pathway

Homologs

ENSEMBL Accession Gene Name Biotype Species E-Value Bit Score
ENST00000268058 PML-001 protein_coding Homo_sapiens 0 1578
ENST00000359928 PML-013 protein_coding Homo_sapiens 1.99993e-41 174
ENST00000395135 PML-006 protein_coding Homo_sapiens 0 1044
ENST00000564428 PML-012 protein_coding Homo_sapiens 0 270
ENST00000565317 PML-021 processed_transcript Homo_sapiens 4e-30 135
ENST00000565898 PML-005 protein_coding Homo_sapiens 0 804
ENST00000569965 PML-008 protein_coding Homo_sapiens 0 1013

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