C-It-Loci: A knowledge database for tissue-enriched loci.

Institute of Cardiovascular Regeneration, Goethe-University Frankfurt am Main

Transcript Info
Description: dedicator of cyto-kinesis 2
Transcript Accession Transcript Name Contained in Gene Tax ID Strand Position Biotype
ENSMUST00000101364 Dock2-201 ENSMUSG00000020143 10090 - 11:34361959-34688479 protein_coding

Expression Patterns

No expression data.

Conserved Regions

Region IDSub-RegionRegion TypePosition
CIL_0000OV CIL_0000OV_0003 CGP 11:34226815-34783892

Gene Ontology

GO IDEvidence TypeGO Description
GO:0001766 IMP membrane raft polarization
GO:0001768 IMP establishment of T cell polarity
GO:0001771 IMP immunological synapse formation
GO:0005085 IEA guanyl-nucleotide exchange factor activity
GO:0006935 IMP chemotaxis
GO:0007010 IDA cytoskeleton organization
GO:0007264 IEA small GTPase mediated signal transduction
GO:0030675 IMP Rac GTPase activator activity
GO:0032855 IMP positive regulation of Rac GTPase activity
GO:0035022 IC positive regulation of Rac protein signal transduction
GO:0042098 IMP T cell proliferation
GO:0042110 IMP T cell activation
GO:0045059 IMP positive thymic T cell selection
GO:0045060 IMP negative thymic T cell selection
GO:0046631 IMP alpha-beta T cell activation
GO:0046633 IMP alpha-beta T cell proliferation

Homologs

ENSEMBL Accession Gene Name Biotype Species E-Value Bit Score
ENST00000256935 DOCK2-001 protein_coding Homo_sapiens 0 874
ENST00000519628 DOCK2-015 protein_coding Homo_sapiens 0 481
ENST00000520181 DOCK2-017 processed_transcript Homo_sapiens 0 616
ENST00000520836 DOCK2-014 processed_transcript Homo_sapiens 0 732
ENST00000520908 DOCK2-004 protein_coding Homo_sapiens 0 874
ENST00000523351 DOCK2-016 processed_transcript Homo_sapiens 0 429
ENST00000524185 DOCK2-002 nonsense_mediated_decay Homo_sapiens 0 874
ENST00000540750 DOCK2-201 protein_coding Homo_sapiens 0 608

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