C-It-Loci: A knowledge database for tissue-enriched loci.

Institute of Cardiovascular Regeneration, Goethe-University Frankfurt am Main

Transcript Info
Description: NLR family, pyrin domain containing 12
Transcript Accession Transcript Name Contained in Gene Tax ID Strand Position Biotype
ENSMUST00000108653 Nlrp12-201 ENSMUSG00000078817 10090 - 7:3221510-3249740 protein_coding

Expression Patterns

Heat Map
Numeric Values
Transcript'; AdiposeBladderBrainBreastColonHeartKidneyLiverLungOvaryPlacentaTestisENSMUST00000108653
Transcript ID Adipose Bladder Brain Breast Colon Heart Kidney Liver Lung Ovary Placenta Testis
ENSMUST00000108653 0.081±0.06 0.017±0.00 0.008±0.01 0.083±0.08 0.038±0.03 0.036±0.02 0.007±0.00 1.238±1.00 0.221±0.04 0.089±0.06 0.050±0.04 0.027±0.01

Conserved Regions

Region IDSub-RegionRegion TypePosition
CIL_0004ML CIL_0004ML_0002 CGP 7:3221510-3299345

Gene Ontology

GO IDEvidence TypeGO Description
GO:0005515 IPI protein binding
GO:0005524 IEA ATP binding
GO:0005737 IEA cytoplasm
GO:0008588 IEA release of cytoplasmic sequestered NF-kappaB
GO:0009968 IEA negative regulation of signal transduction
GO:0031953 IEA negative regulation of protein autophosphorylation
GO:0032088 IEA negative regulation of NF-kappaB transcription factor activity
GO:0036336 IMP dendritic cell migration
GO:0043122 IEA regulation of I-kappaB kinase/NF-kappaB signaling
GO:0043124 IEA negative regulation of I-kappaB kinase/NF-kappaB signaling
GO:0043281 IEA regulation of cysteine-type endopeptidase activity involved in apoptotic process
GO:0045345 IEA positive regulation of MHC class I biosynthetic process
GO:0045409 IEA negative regulation of interleukin-6 biosynthetic process
GO:0045751 IEA negative regulation of Toll signaling pathway
GO:0050710 IEA negative regulation of cytokine secretion
GO:0050711 IEA negative regulation of interleukin-1 secretion
GO:0050728 IEA negative regulation of inflammatory response
GO:0070373 IMP negative regulation of ERK1 and ERK2 cascade
GO:0071345 IMP cellular response to cytokine stimulus
GO:1901223 IMP negative regulation of NIK/NF-kappaB signaling

Homologs

ENSEMBL Accession Gene Name Biotype Species E-Value Bit Score
ENST00000324134 NLRP12-001 protein_coding Homo_sapiens 0 1784
ENST00000345770 NLRP12-004 protein_coding Homo_sapiens 0 1572
ENST00000391772 NLRP12-007 protein_coding Homo_sapiens 0 1351
ENST00000391773 NLRP12-002 protein_coding Homo_sapiens 0 1777
ENST00000391775 NLRP12-003 protein_coding Homo_sapiens 0 1476

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