C-It-Loci: A knowledge database for tissue-enriched loci.

Institute of Cardiovascular Regeneration, Goethe-University Frankfurt am Main

Transcript Info
Description: presenilin 2
Transcript Accession Transcript Name Contained in Gene Tax ID Strand Position Biotype
ENSMUST00000111104 Psen2-004 ENSMUSG00000010609 10090 - 1:180227445-180245757 protein_coding

Expression Patterns

Heat Map
Numeric Values
Transcript'; AdiposeAdrenalBrainBreastColonHeartLiverOvaryPlacentaTestisENSMUST00000111104
Transcript ID Adipose Adrenal Brain Breast Colon Heart Liver Ovary Placenta Testis
ENSMUST00000111104 9.476±0.73 9.353±1.26 1.974±0.42 15.179±1.45 3.651±1.56 2.546±0.00 2.980±0.00 22.946±7.07 3.607±0.00 0.936±0.06

Conserved Regions

Region IDSub-RegionRegion TypePosition
CIL_000985 CIL_000985_0002 VISTA 1:179908053-180512549
CIL_0008CY CIL_0008CY_0002 VISTA 1:179968494-180569356

Gene Ontology

GO IDEvidence TypeGO Description
GO:0000122 IMP negative regulation of transcription from RNA polymerase II promoter
GO:0001708 IGI cell fate specification
GO:0001756 IGI somitogenesis
GO:0001921 IMP positive regulation of receptor recycling
GO:0001933 IGI negative regulation of protein phosphorylation
GO:0001942 IGI hair follicle development
GO:0002244 IGI hematopoietic progenitor cell differentiation
GO:0002286 IGI T cell activation involved in immune response
GO:0002573 IGI myeloid leukocyte differentiation
GO:0004175 IMP endopeptidase activity
GO:0004190 IEA aspartic-type endopeptidase activity
GO:0005515 IPI protein binding
GO:0005634 IBA nucleus
GO:0005743 IBA mitochondrial inner membrane
GO:0005765 IBA lysosomal membrane
GO:0005783 IDA:ISS endoplasmic reticulum
GO:0005794 ISS Golgi apparatus
GO:0005829 IDA cytosol
GO:0005886 TAS plasma membrane
GO:0005887 IBA:ISS integral component of plasma membrane
GO:0005938 IBA cell cortex
GO:0006509 IBA:ISS membrane protein ectodomain proteolysis
GO:0006816 IPI calcium ion transport
GO:0007175 IMP negative regulation of epidermal growth factor-activated receptor activity
GO:0007176 IGI regulation of epidermal growth factor-activated receptor activity
GO:0007219 IGI Notch signaling pathway
GO:0007220 IBA Notch receptor processing
GO:0007611 IGI learning or memory
GO:0007613 IGI memory
GO:0009986 IBA cell surface
GO:0015031 IGI protein transport
GO:0016020 IDA membrane
GO:0016324 IBA apical plasma membrane
GO:0016485 IGI:ISS protein processing
GO:0021904 IGI dorsal/ventral neural tube patterning
GO:0030018 IDA Z disc
GO:0030326 IGI embryonic limb morphogenesis
GO:0030424 IBA axon
GO:0030426 IBA growth cone
GO:0030900 IGI forebrain development
GO:0031333 IDA negative regulation of protein complex assembly
GO:0031594 IBA neuromuscular junction
GO:0032091 IDA negative regulation of protein binding
GO:0032436 IMP positive regulation of proteasomal ubiquitin-dependent protein catabolic process
GO:0032469 IGI endoplasmic reticulum calcium ion homeostasis
GO:0035253 IBA ciliary rootlet
GO:0035556 IEA intracellular signal transduction
GO:0036064 IDA ciliary basal body
GO:0040011 IGI locomotion
GO:0042987 IBA amyloid precursor protein catabolic process
GO:0043025 IDA neuronal cell body
GO:0043065 IGI positive regulation of apoptotic process
GO:0043066 IBA negative regulation of apoptotic process
GO:0043085 ISS positive regulation of catalytic activity
GO:0043198 IBA dendritic shaft
GO:0043393 IGI regulation of protein binding
GO:0043589 IMP skin morphogenesis
GO:0044267 IGI cellular protein metabolic process
GO:0045121 IBA membrane raft
GO:0048167 IGI regulation of synaptic plasticity
GO:0048286 IMP lung alveolus development
GO:0048471 IBA perinuclear region of cytoplasm
GO:0048538 IGI thymus development
GO:0048854 IGI brain morphogenesis
GO:0050435 IDA beta-amyloid metabolic process
GO:0050820 IMP positive regulation of coagulation
GO:0050852 IGI T cell receptor signaling pathway
GO:0051444 IMP negative regulation of ubiquitin-protein transferase activity
GO:0051604 IGI protein maturation
GO:0060048 IMP cardiac muscle contraction
GO:1902042 IDA negative regulation of extrinsic apoptotic signaling pathway via death domain receptors
GO:1902043 IDA positive regulation of extrinsic apoptotic signaling pathway via death domain receptors
GO:2000059 IMP negative regulation of protein ubiquitination involved in ubiquitin-dependent protein catabolic process
GO:2001234 IGI negative regulation of apoptotic signaling pathway

Homologs

ENSEMBL Accession Gene Name Biotype Species E-Value Bit Score
ENST00000366782 PSEN2-002 protein_coding Homo_sapiens 0 1742
ENST00000366783 PSEN2-001 protein_coding Homo_sapiens 0 1742
ENST00000422240 PSEN2-007 protein_coding Homo_sapiens 0 1757
ENST00000460775 PSEN2-005 protein_coding Homo_sapiens 0 621
ENST00000471728 PSEN2-009 processed_transcript Homo_sapiens 0 532
ENST00000472139 PSEN2-006 protein_coding Homo_sapiens 0 1339
ENST00000495488 PSEN2-004 protein_coding Homo_sapiens 0 444
ENST00000524196 PSEN2-010 protein_coding Homo_sapiens 8e-18 95

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