C-It-Loci: A knowledge database for tissue-enriched loci.

Institute of Cardiovascular Regeneration, Goethe-University Frankfurt am Main

Transcript Info
Description: presenilin 2
Transcript Accession Transcript Name Contained in Gene Tax ID Strand Position Biotype
ENSMUST00000111108 Psen2-001 ENSMUSG00000010609 10090 - 1:180227004-180256300 protein_coding

Mus musculus EnsemblGRCm38

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Genes
Structures from Ensembl
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Transcripts
Structures from Ensembl
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Expression Patterns

Heat Map
Numeric Values
Transcript'; AdiposeAdrenalBladderBrainBreastColonHeartKidneyLiverLungMuscleOvaryPlacentaTestisENSMUST00000111108
Transcript ID Adipose Adrenal Bladder Brain Breast Colon Heart Kidney Liver Lung Muscle Ovary Placenta Testis
ENSMUST00000111108 23.783±2.66 17.669±5.80 13.650±1.54 3.567±1.46 22.871±9.88 12.104±1.82 7.773±1.13 14.838±1.48 18.419±6.48 23.269±1.46 3.743±0.94 26.890±6.33 9.188±4.46 2.064±1.23

Conserved Regions

Region IDSub-RegionRegion TypePosition
CIL_000985 CIL_000985_0002 VISTA 1:179908053-180512549
CIL_0008CY CIL_0008CY_0002 VISTA 1:179968494-180569356

Gene Ontology

GO IDEvidence TypeGO Description
GO:0000139 IEA Golgi membrane
GO:0001708 IGI cell fate specification
GO:0001756 IGI somitogenesis
GO:0001933 IGI negative regulation of protein phosphorylation
GO:0001942 IGI hair follicle development
GO:0002244 IGI hematopoietic progenitor cell differentiation
GO:0002286 IGI T cell activation involved in immune response
GO:0002573 IGI myeloid leukocyte differentiation
GO:0004175 IMP endopeptidase activity
GO:0004190 IEA aspartic-type endopeptidase activity
GO:0005515 IPI protein binding
GO:0005634 IBA nucleus
GO:0005743 IBA mitochondrial inner membrane
GO:0005765 IBA lysosomal membrane
GO:0005783 IDA endoplasmic reticulum
GO:0005789 IEA endoplasmic reticulum membrane
GO:0005829 IDA cytosol
GO:0005887 IBA integral component of plasma membrane
GO:0005938 IBA cell cortex
GO:0006509 IBA membrane protein ectodomain proteolysis
GO:0006816 IPI calcium ion transport
GO:0007176 IGI regulation of epidermal growth factor-activated receptor activity
GO:0007219 IGI Notch signaling pathway
GO:0007220 IBA Notch receptor processing
GO:0007611 IGI learning or memory
GO:0007613 IGI memory
GO:0009986 IBA cell surface
GO:0015031 IGI protein transport
GO:0016020 IDA membrane
GO:0016324 IBA apical plasma membrane
GO:0016485 IGI protein processing
GO:0021904 IGI dorsal/ventral neural tube patterning
GO:0030018 IDA Z disc
GO:0030326 IGI embryonic limb morphogenesis
GO:0030424 IBA axon
GO:0030426 IBA growth cone
GO:0030900 IGI forebrain development
GO:0031333 IDA negative regulation of protein complex assembly
GO:0031594 IBA neuromuscular junction
GO:0032091 IDA negative regulation of protein binding
GO:0032469 IGI endoplasmic reticulum calcium ion homeostasis
GO:0035253 IBA ciliary rootlet
GO:0035556 IEA intracellular signal transduction
GO:0036064 IDA ciliary basal body
GO:0040011 IGI locomotion
GO:0042987 IBA amyloid precursor protein catabolic process
GO:0043025 IDA neuronal cell body
GO:0043065 IGI positive regulation of apoptotic process
GO:0043066 IBA negative regulation of apoptotic process
GO:0043198 IBA dendritic shaft
GO:0043393 IGI regulation of protein binding
GO:0044267 IGI cellular protein metabolic process
GO:0045121 IBA membrane raft
GO:0048167 IGI regulation of synaptic plasticity
GO:0048286 IMP lung alveolus development
GO:0048471 IBA perinuclear region of cytoplasm
GO:0048538 IGI thymus development
GO:0048854 IGI brain morphogenesis
GO:0050435 IDA beta-amyloid metabolic process
GO:0050820 IMP positive regulation of coagulation
GO:0050852 IGI T cell receptor signaling pathway
GO:0051604 IGI protein maturation
GO:0060048 IMP cardiac muscle contraction
GO:1902042 IDA negative regulation of extrinsic apoptotic signaling pathway via death domain receptors
GO:1902043 IDA positive regulation of extrinsic apoptotic signaling pathway via death domain receptors
GO:2001234 IGI negative regulation of apoptotic signaling pathway

Homologs

ENSEMBL Accession Gene Name Biotype Species E-Value Bit Score
ENST00000366782 PSEN2-002 protein_coding Homo_sapiens 0 1762
ENST00000366783 PSEN2-001 protein_coding Homo_sapiens 0 1762
ENST00000422240 PSEN2-007 protein_coding Homo_sapiens 0 1742
ENST00000460775 PSEN2-005 protein_coding Homo_sapiens 0 621
ENST00000471728 PSEN2-009 processed_transcript Homo_sapiens 0 518
ENST00000472139 PSEN2-006 protein_coding Homo_sapiens 0 1360
ENST00000495488 PSEN2-004 protein_coding Homo_sapiens 0 444
ENST00000524196 PSEN2-010 protein_coding Homo_sapiens 8e-18 95

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