C-It-Loci: A knowledge database for tissue-enriched loci.

Institute of Cardiovascular Regeneration, Goethe-University Frankfurt am Main

Transcript Info
Description: nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha
Transcript Accession Transcript Name Contained in Gene Tax ID Strand Position Biotype
ENST00000216797 NFKBIA-001 ENSG00000100906 9606 - 14:35401511-35404746 protein_coding

Expression Patterns

Heat Map
Numeric Values
Transcript'; AdiposeAdrenalBladderBrainBreastColonHeartKidneyLiverLungMuscleOvaryPlacentaTestisENST00000216797
Transcript ID Adipose Adrenal Bladder Brain Breast Colon Heart Kidney Liver Lung Muscle Ovary Placenta Testis
ENST00000216797 18.237±0.00 68.348±0.00 3.593±0.00 6.084±2.25 12.193±1.23 25.062±18.25 6.471±2.62 22.730±11.89 9.026±0.36 38.484±17.32 9.992±8.83 53.417±36.46 58.714±28.07 23.220±20.37

Conserved Regions

Region IDSub-RegionRegion TypePosition
CIL_0008MF CIL_0008MF_0001 VISTA 14:35250818-35851792
CIL_0008ME CIL_0008ME_0001 VISTA 14:35273755-35874460
CIL_0001RJ CIL_0001RJ_0001 CGP 14:35278633-35404749

Gene Ontology

GO IDEvidence TypeGO Description
GO:0000060 IEA protein import into nucleus, translocation
GO:0002224 TAS toll-like receptor signaling pathway
GO:0002755 TAS MyD88-dependent toll-like receptor signaling pathway
GO:0002756 TAS MyD88-independent toll-like receptor signaling pathway
GO:0005515 IPI:IEA protein binding
GO:0005634 IDA nucleus
GO:0005737 IDA cytoplasm
GO:0005829 TAS cytosol
GO:0005886 IDA plasma membrane
GO:0006915 TAS apoptotic process
GO:0007253 IMP cytoplasmic sequestering of NF-kappaB
GO:0008134 TAS transcription factor binding
GO:0008139 IPI nuclear localization sequence binding
GO:0010468 IEA regulation of gene expression
GO:0010745 IMP negative regulation of macrophage derived foam cell differentiation
GO:0010875 IMP positive regulation of cholesterol efflux
GO:0010888 IMP negative regulation of lipid storage
GO:0016032 IEA viral process
GO:0019899 IPI enzyme binding
GO:0031072 IEA heat shock protein binding
GO:0031625 IPI ubiquitin protein ligase binding
GO:0031663 IEA lipopolysaccharide-mediated signaling pathway
GO:0032088 IDA negative regulation of NF-kappaB transcription factor activity
GO:0032270 IMP positive regulation of cellular protein metabolic process
GO:0032403 IEA protein complex binding
GO:0032481 TAS positive regulation of type I interferon production
GO:0032495 IEA response to muramyl dipeptide
GO:0032496 IEA response to lipopolysaccharide
GO:0033256 TAS I-kappaB/NF-kappaB complex
GO:0034134 TAS toll-like receptor 2 signaling pathway
GO:0034138 TAS toll-like receptor 3 signaling pathway
GO:0034142 TAS toll-like receptor 4 signaling pathway
GO:0034146 TAS toll-like receptor 5 signaling pathway
GO:0034162 TAS toll-like receptor 9 signaling pathway
GO:0034166 TAS toll-like receptor 10 signaling pathway
GO:0035666 TAS TRIF-dependent toll-like receptor signaling pathway
GO:0038095 TAS Fc-epsilon receptor signaling pathway
GO:0038123 TAS toll-like receptor TLR1:TLR2 signaling pathway
GO:0038124 TAS toll-like receptor TLR6:TLR2 signaling pathway
GO:0042127 IEA regulation of cell proliferation
GO:0042345 NAS regulation of NF-kappaB import into nucleus
GO:0042802 IPI identical protein binding
GO:0042994 IDA cytoplasmic sequestering of transcription factor
GO:0043066 TAS negative regulation of apoptotic process
GO:0043234 IEA protein complex
GO:0043330 IEA response to exogenous dsRNA
GO:0043392 NAS negative regulation of DNA binding
GO:0045087 TAS innate immune response
GO:0045638 IEA negative regulation of myeloid cell differentiation
GO:0045746 IEA negative regulation of Notch signaling pathway
GO:0045893 IEA positive regulation of transcription, DNA-templated
GO:0045944 IMP positive regulation of transcription from RNA polymerase II promoter
GO:0048011 TAS neurotrophin TRK receptor signaling pathway
GO:0050852 TAS T cell receptor signaling pathway
GO:0051059 IDA NF-kappaB binding
GO:0051092 TAS positive regulation of NF-kappaB transcription factor activity
GO:0070417 NAS cellular response to cold
GO:0070427 IEA nucleotide-binding oligomerization domain containing 1 signaling pathway
GO:0070431 IEA nucleotide-binding oligomerization domain containing 2 signaling pathway

Homologs

ENSEMBL Accession Gene Name Biotype Species E-Value Bit Score
ENSMUST00000021413 Nfkbia-201 protein_coding Mus_musculus 0 1262

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