C-It-Loci: A knowledge database for tissue-enriched loci.

Institute of Cardiovascular Regeneration, Goethe-University Frankfurt am Main

Transcript Info
Description: activin A receptor, type IIA
Transcript Accession Transcript Name Contained in Gene Tax ID Strand Position Biotype
ENST00000241416 ACVR2A-001 ENSG00000121989 9606 + 2:147844517-147930824 protein_coding

Homo sapiens EnsemblGRCh38

Genome
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Genes
Structures from Ensembl
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Transcripts
Structures from Ensembl
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Expression Patterns

Heat Map
Numeric Values
Transcript'; AdiposeAdrenalBladderBreastLiverLungMuscleOvaryPlacentaTestisENST00000241416
Transcript ID Adipose Adrenal Bladder Breast Liver Lung Muscle Ovary Placenta Testis
ENST00000241416 1.262±0.00 1.910±0.00 2.349±0.00 1.927±0.00 0.696±0.00 4.268±0.00 1.365±0.00 1.774±0.00 1.398±0.64 2.297±0.00

Conserved Regions

Region IDSub-RegionRegion TypePosition
CIL_0007GY CIL_0007GY_0001 CGP 2:144388001-147930826
CIL_0006MB CIL_0006MB_0001 CGP 2:147844517-148021604

Gene Ontology

GO IDEvidence TypeGO Description
GO:0001702 IEA gastrulation with mouth forming second
GO:0001934 IMP positive regulation of protein phosphorylation
GO:0004672 IEA protein kinase activity
GO:0004674 EXP protein serine/threonine kinase activity
GO:0004675 TAS:IEA transmembrane receptor protein serine/threonine kinase activity
GO:0004702 IEA receptor signaling protein serine/threonine kinase activity
GO:0004713 IEA protein tyrosine kinase activity
GO:0005024 IEA transforming growth factor beta-activated receptor activity
GO:0005515 IPI protein binding
GO:0005524 IEA ATP binding
GO:0005737 IDA cytoplasm
GO:0005886 TAS plasma membrane
GO:0005887 TAS integral component of plasma membrane
GO:0006468 IEA protein phosphorylation
GO:0007178 TAS transmembrane receptor protein serine/threonine kinase signaling pathway
GO:0007283 IEA spermatogenesis
GO:0007368 IEA determination of left/right symmetry
GO:0007498 IEA mesoderm development
GO:0008584 IEA male gonad development
GO:0009952 IEA anterior/posterior pattern specification
GO:0009966 IEA regulation of signal transduction
GO:0009986 IEA cell surface
GO:0010862 IMP positive regulation of pathway-restricted SMAD protein phosphorylation
GO:0015026 IDA coreceptor activity
GO:0016020 IEA membrane
GO:0016772 IEA transferase activity, transferring phosphorus-containing groups
GO:0017002 IDA activin-activated receptor activity
GO:0019838 IEA growth factor binding
GO:0023014 IEA signal transduction by phosphorylation
GO:0030165 IEA PDZ domain binding
GO:0030501 IMP positive regulation of bone mineralization
GO:0030509 IMP BMP signaling pathway
GO:0030510 IEA regulation of BMP signaling pathway
GO:0032924 IDA activin receptor signaling pathway
GO:0032927 IDA positive regulation of activin receptor signaling pathway
GO:0034673 IDA inhibin-betaglycan-ActRII complex
GO:0034711 IEA inhibin binding
GO:0042713 IEA sperm ejaculation
GO:0043084 IEA penile erection
GO:0043621 IEA protein self-association
GO:0045648 IDA positive regulation of erythrocyte differentiation
GO:0045669 IMP positive regulation of osteoblast differentiation
GO:0046872 IEA metal ion binding
GO:0048185 IPI activin binding
GO:0048706 IEA embryonic skeletal system development
GO:0050999 IEA regulation of nitric-oxide synthase activity
GO:0060011 IEA Sertoli cell proliferation
GO:0071773 IMP cellular response to BMP stimulus

Homologs

ENSEMBL Accession Gene Name Biotype Species E-Value Bit Score
ENSMUST00000063886 Acvr2a-001 protein_coding Mus_musculus 0 4970
ENSMUST00000156681 Acvr2a-002 processed_transcript Mus_musculus 0 900
ENSMUST00000028098 Orc4-001 protein_coding Mus_musculus 0 558

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