C-It-Loci: A knowledge database for tissue-enriched loci.

Institute of Cardiovascular Regeneration, Goethe-University Frankfurt am Main

Transcript Info
Description: 5-hydroxytryptamine (serotonin) receptor 2B, G protein-coupled
Transcript Accession Transcript Name Contained in Gene Tax ID Strand Position Biotype
ENST00000258400 HTR2B-001 ENSG00000135914 9606 - 2:231108230-231125118 protein_coding

Expression Patterns

Heat Map
Numeric Values
Transcript'; PlacentaENST00000258400
Transcript ID Placenta
ENST00000258400 3.566±0.00

Conserved Regions

Region IDSub-RegionRegion TypePosition
CIL_00076M CIL_00076M_0001 CGP 2:231037490-231172827
CIL_0004KX CIL_0004KX_0002 CGP 2:231056864-231172827

Gene Ontology

GO IDEvidence TypeGO Description
GO:0001755 ISS neural crest cell migration
GO:0001819 IDA positive regulation of cytokine production
GO:0001938 IMP positive regulation of endothelial cell proliferation
GO:0001965 IMP G-protein alpha-subunit binding
GO:0002031 IEA G-protein coupled receptor internalization
GO:0003007 ISS heart morphogenesis
GO:0003300 ISS cardiac muscle hypertrophy
GO:0004930 IEA G-protein coupled receptor activity
GO:0004993 IDA serotonin receptor activity
GO:0005099 ISS Ras GTPase activator activity
GO:0005737 IDA cytoplasm
GO:0005886 IDA plasma membrane
GO:0005887 IEA integral component of plasma membrane
GO:0006182 IDA cGMP biosynthetic process
GO:0006874 IDA cellular calcium ion homeostasis
GO:0007186 IMP:IEA G-protein coupled receptor signaling pathway
GO:0007202 IDA activation of phospholipase C activity
GO:0007205 ISS protein kinase C-activating G-protein coupled receptor signaling pathway
GO:0007210 IMP serotonin receptor signaling pathway
GO:0007507 IEA heart development
GO:0007610 IEA behavior
GO:0008144 IDA drug binding
GO:0008284 IDA positive regulation of cell proliferation
GO:0010507 IMP negative regulation of autophagy
GO:0010513 IDA positive regulation of phosphatidylinositol biosynthetic process
GO:0014033 ISS neural crest cell differentiation
GO:0014065 IDA phosphatidylinositol 3-kinase signaling
GO:0014827 IMP intestine smooth muscle contraction
GO:0016021 IEA integral component of membrane
GO:0016310 IMP phosphorylation
GO:0019722 IMP calcium-mediated signaling
GO:0030054 IEA cell junction
GO:0032320 IEA positive regulation of Ras GTPase activity
GO:0042310 IMP vasoconstriction
GO:0042493 IDA response to drug
GO:0043005 IEA neuron projection
GO:0043066 ISS negative regulation of apoptotic process
GO:0043123 IEP positive regulation of I-kappaB kinase/NF-kappaB signaling
GO:0043406 IDA positive regulation of MAP kinase activity
GO:0045202 IEA synapse
GO:0048598 ISS embryonic morphogenesis
GO:0050715 ISS positive regulation of cytokine secretion
GO:0050795 IMP regulation of behavior
GO:0051000 IDA positive regulation of nitric-oxide synthase activity
GO:0051209 IDA release of sequestered calcium ion into cytosol
GO:0051378 IDA serotonin binding
GO:0051781 ISS positive regulation of cell division
GO:0060548 IMP negative regulation of cell death
GO:0070371 IMP ERK1 and ERK2 cascade
GO:0070374 IDA positive regulation of ERK1 and ERK2 cascade
GO:0070528 IMP protein kinase C signaling
GO:0071502 ISS cellular response to temperature stimulus

Homologs

ENSEMBL Accession Gene Name Biotype Species E-Value Bit Score
ENSMUST00000027431 Htr2b-001 protein_coding Mus_musculus 0 1530
ENSMUST00000155077 Htr2b-002 protein_coding Mus_musculus 0 427

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