C-It-Loci: A knowledge database for tissue-enriched loci.

Institute of Cardiovascular Regeneration, Goethe-University Frankfurt am Main

Transcript Info
Description: interleukin-1 receptor-associated kinase 3
Transcript Accession Transcript Name Contained in Gene Tax ID Strand Position Biotype
ENST00000261233 IRAK3-001 ENSG00000090376 9606 + 12:66188879-66254622 protein_coding

Expression Patterns

Heat Map
Numeric Values
Transcript'; AdiposeAdrenalBladderBrainBreastColonHeartKidneyLiverLungMuscleOvaryPlacentaTestisENST00000261233
Transcript ID Adipose Adrenal Bladder Brain Breast Colon Heart Kidney Liver Lung Muscle Ovary Placenta Testis
ENST00000261233 7.716±0.00 2.320±0.00 0.071±0.00 0.424±0.08 1.065±0.17 1.070±0.66 1.644±0.81 0.633±0.00 0.929±0.45 3.670±0.85 0.407±0.00 0.689±0.46 0.781±0.29 0.848±0.20

Conserved Regions

Gene is not located within a conserved region.

Gene Ontology

GO IDEvidence TypeGO Description
GO:0000287 IDA magnesium ion binding
GO:0001960 IC negative regulation of cytokine-mediated signaling pathway
GO:0002755 TAS MyD88-dependent toll-like receptor signaling pathway
GO:0004672 IEA protein kinase activity
GO:0004674 IDA protein serine/threonine kinase activity
GO:0004713 IEA protein tyrosine kinase activity
GO:0005515 IEA protein binding
GO:0005524 IDA:IEA ATP binding
GO:0005634 IDA nucleus
GO:0005737 IDA cytoplasm
GO:0006468 IDA:IEA protein phosphorylation
GO:0007165 IEA signal transduction
GO:0009615 IC response to virus
GO:0010933 ISS positive regulation of macrophage tolerance induction
GO:0010936 ISS negative regulation of macrophage cytokine production
GO:0016772 IEA transferase activity, transferring phosphorus-containing groups
GO:0019221 ISS cytokine-mediated signaling pathway
GO:0032088 IMP negative regulation of NF-kappaB transcription factor activity
GO:0032494 ISS response to peptidoglycan
GO:0032496 ISS response to lipopolysaccharide
GO:0032695 ISS negative regulation of interleukin-12 production
GO:0032715 ISS negative regulation of interleukin-6 production
GO:0032720 IMP negative regulation of tumor necrosis factor production
GO:0034122 ISS negative regulation of toll-like receptor signaling pathway
GO:0042177 IMP negative regulation of protein catabolic process
GO:0042803 IPI protein homodimerization activity
GO:0043242 IMP negative regulation of protein complex disassembly
GO:0043244 ISS regulation of protein complex disassembly
GO:0043330 ISS response to exogenous dsRNA
GO:0043407 IMP negative regulation of MAP kinase activity
GO:0045824 ISS negative regulation of innate immune response
GO:0046777 IEA protein autophosphorylation
GO:0046982 IPI protein heterodimerization activity
GO:0051092 IMP positive regulation of NF-kappaB transcription factor activity
GO:0070498 IMP interleukin-1-mediated signaling pathway
GO:0070555 IMP response to interleukin-1

Homologs

ENSEMBL Accession Gene Name Biotype Species E-Value Bit Score
ENSMUST00000135106 Irak3-004 nonsense_mediated_decay Mus_musculus 0 351
ENSMUST00000143100 Irak3-003 retained_intron Mus_musculus 0 351
ENSMUST00000020448 Irak3-001 protein_coding Mus_musculus 0 351
ENSMUST00000145665 Irak3-002 protein_coding Mus_musculus 0 235

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