C-It-Loci: A knowledge database for tissue-enriched loci.

Institute of Cardiovascular Regeneration, Goethe-University Frankfurt am Main

Transcript Info
Description: low density lipoprotein receptor-related protein 6
Transcript Accession Transcript Name Contained in Gene Tax ID Strand Position Biotype
ENST00000261349 LRP6-001 ENSG00000070018 9606 - 12:12116025-12266812 protein_coding

Expression Patterns

Heat Map
Numeric Values
Transcript'; AdiposeAdrenalBrainBreastColonHeartKidneyLiverLungMuscleOvaryPlacentaTestisENST00000261349
Transcript ID Adipose Adrenal Brain Breast Colon Heart Kidney Liver Lung Muscle Ovary Placenta Testis
ENST00000261349 1.364±0.00 1.039±0.00 1.855±0.00 1.856±0.00 3.002±0.74 1.560±0.00 3.259±1.28 1.304±0.02 3.967±1.94 0.343±0.00 2.678±1.65 2.712±0.23 1.511±0.00

Conserved Regions

Region IDSub-RegionRegion TypePosition
CIL_0000K4 CIL_0000K4_0001 CGP 12:11649854-12211084
CIL_0003HK CIL_0003HK_0001 CGP 12:12049844-12267012
CIL_0006X9 CIL_0006X9_0002 CGP 12:12116025-12350541

Gene Ontology

GO IDEvidence TypeGO Description
GO:0001702 IBA gastrulation with mouth forming second
GO:0001756 IEA somitogenesis
GO:0001843 IBA neural tube closure
GO:0001933 IMP negative regulation of protein phosphorylation
GO:0001947 IEA heart looping
GO:0002053 IEA positive regulation of mesenchymal cell proliferation
GO:0003344 IBA pericardium morphogenesis
GO:0003401 IEA axis elongation
GO:0005041 IDA low-density lipoprotein receptor activity
GO:0005102 IPI receptor binding
GO:0005109 IPI frizzled binding
GO:0005515 IPI:IEA protein binding
GO:0005769 IDA early endosome
GO:0005783 IEA endoplasmic reticulum
GO:0005794 IDA Golgi apparatus
GO:0005886 IDA plasma membrane
GO:0005901 IDA caveola
GO:0006355 IEA regulation of transcription, DNA-templated
GO:0006469 IMP negative regulation of protein kinase activity
GO:0007204 IEA positive regulation of cytosolic calcium ion concentration
GO:0007268 IBA synaptic transmission
GO:0009880 IBA embryonic pattern specification
GO:0009950 IEA dorsal/ventral axis specification
GO:0009952 IBA anterior/posterior pattern specification
GO:0009986 IDA cell surface
GO:0014029 IDA neural crest formation
GO:0014033 IDA neural crest cell differentiation
GO:0016020 IEA membrane
GO:0016021 IEA integral component of membrane
GO:0016055 IMP Wnt signaling pathway
GO:0016337 IEA single organismal cell-cell adhesion
GO:0017147 IPI Wnt-protein binding
GO:0019210 IMP kinase inhibitor activity
GO:0019534 IMP toxin transporter activity
GO:0021587 IBA cerebellum morphogenesis
GO:0021794 IBA thalamus development
GO:0021795 IEA cerebral cortex cell migration
GO:0021861 IEA forebrain radial glial cell differentiation
GO:0021872 IEA forebrain generation of neurons
GO:0021874 IEA Wnt signaling pathway involved in forebrain neuroblast division
GO:0021915 IEA neural tube development
GO:0021943 IEA formation of radial glial scaffolds
GO:0021987 IBA cerebral cortex development
GO:0030178 IEA negative regulation of Wnt signaling pathway
GO:0030278 IBA regulation of ossification
GO:0030326 IBA embryonic limb morphogenesis
GO:0030900 IEA forebrain development
GO:0030901 IBA midbrain development
GO:0030917 IBA midbrain-hindbrain boundary development
GO:0031410 IDA cytoplasmic vesicle
GO:0034185 IBA apolipoprotein binding
GO:0034392 IMP negative regulation of smooth muscle cell apoptotic process
GO:0035108 IEA limb morphogenesis
GO:0035115 IEA embryonic forelimb morphogenesis
GO:0035116 IEA embryonic hindlimb morphogenesis
GO:0035261 IBA external genitalia morphogenesis
GO:0036342 IEA post-anal tail morphogenesis
GO:0042074 IEA cell migration involved in gastrulation
GO:0042127 IEA regulation of cell proliferation
GO:0042475 IBA odontogenesis of dentin-containing tooth
GO:0042733 IEA embryonic digit morphogenesis
GO:0042802 IPI identical protein binding
GO:0042803 IPI protein homodimerization activity
GO:0042813 IBA Wnt-activated receptor activity
GO:0043025 IBA neuronal cell body
GO:0043065 IEA positive regulation of apoptotic process
GO:0043235 IBA receptor complex
GO:0043434 IEA response to peptide hormone
GO:0044332 IDA Wnt signaling pathway involved in dorsal/ventral axis specification
GO:0044335 IC canonical Wnt signaling pathway involved in neural crest cell differentiation
GO:0044340 IC canonical Wnt signaling pathway involved in regulation of cell proliferation
GO:0045202 IBA synapse
GO:0045598 IBA regulation of fat cell differentiation
GO:0045599 IEA negative regulation of fat cell differentiation
GO:0045778 IEA positive regulation of ossification
GO:0045780 IEA positive regulation of bone resorption
GO:0045787 IMP positive regulation of cell cycle
GO:0045893 IMP positive regulation of transcription, DNA-templated
GO:0045944 IDA positive regulation of transcription from RNA polymerase II promoter
GO:0046849 IBA bone remodeling
GO:0048596 IBA embryonic camera-type eye morphogenesis
GO:0048699 IEA generation of neurons
GO:0048705 IEA skeletal system morphogenesis
GO:0050680 IEA negative regulation of epithelial cell proliferation
GO:0051091 IDA positive regulation of sequence-specific DNA binding transcription factor activity
GO:0051593 IEA response to folic acid
GO:0060021 IBA palate development
GO:0060026 IBA convergent extension
GO:0060042 IEA retina morphogenesis in camera-type eye
GO:0060059 IBA embryonic retina morphogenesis in camera-type eye
GO:0060070 IDA canonical Wnt signaling pathway
GO:0060284 IEA regulation of cell development
GO:0060325 IBA face morphogenesis
GO:0060349 IBA bone morphogenesis
GO:0060444 IBA branching involved in mammary gland duct morphogenesis
GO:0060535 IBA trachea cartilage morphogenesis
GO:0060596 IEA mammary placode formation
GO:0060603 IEA mammary gland duct morphogenesis
GO:0061310 IEA canonical Wnt signaling pathway involved in cardiac neural crest cell differentiation involved in heart development
GO:0061324 IEA canonical Wnt signaling pathway involved in positive regulation of cardiac outflow tract cell proliferation
GO:0071397 IMP cellular response to cholesterol
GO:0071542 IEA dopaminergic neuron differentiation
GO:0071901 IDA negative regulation of protein serine/threonine kinase activity
GO:0071936 IDA coreceptor activity involved in Wnt signaling pathway
GO:0090009 IBA primitive streak formation
GO:0090118 IBA receptor-mediated endocytosis of low-density lipoprotein particle involved in cholesterol transport
GO:0090244 IBA Wnt signaling pathway involved in somitogenesis
GO:0090245 IBA axis elongation involved in somitogenesis
GO:0090263 IDA positive regulation of canonical Wnt signaling pathway
GO:1901998 IMP toxin transport
GO:2000051 IEA negative regulation of non-canonical Wnt signaling pathway
GO:2000055 IDA positive regulation of Wnt signaling pathway involved in dorsal/ventral axis specification
GO:2000149 IEA negative regulation of planar cell polarity pathway involved in ventricular septum morphogenesis
GO:2000151 IEA negative regulation of planar cell polarity pathway involved in cardiac muscle tissue morphogenesis
GO:2000162 IEA negative regulation of planar cell polarity pathway involved in cardiac right atrium morphogenesis
GO:2000164 IEA negative regulation of planar cell polarity pathway involved in outflow tract morphogenesis
GO:2000166 IEA negative regulation of planar cell polarity pathway involved in pericardium morphogenesis
GO:2000168 IEA negative regulation of planar cell polarity pathway involved in neural tube closure

Homologs

ENSEMBL Accession Gene Name Biotype Species E-Value Bit Score
ENSMUST00000032322 Lrp6-001 protein_coding Mus_musculus 0 7081
ENSMUST00000111950 Lrp6-003 protein_coding Mus_musculus 0 3068
ENSMUST00000126836 Lrp6-002 processed_transcript Mus_musculus 0 579

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