C-It-Loci: A knowledge database for tissue-enriched loci.

Institute of Cardiovascular Regeneration, Goethe-University Frankfurt am Main

Transcript Info
Description: platelet-derived growth factor receptor, beta polypeptide
Transcript Accession Transcript Name Contained in Gene Tax ID Strand Position Biotype
ENST00000261799 PDGFRB-001 ENSG00000113721 9606 - 5:150113837-150155860 protein_coding

Expression Patterns

Heat Map
Numeric Values
Transcript'; AdiposeAdrenalBladderBrainBreastColonHeartKidneyLiverLungMuscleOvaryPlacentaTestisENST00000261799
Transcript ID Adipose Adrenal Bladder Brain Breast Colon Heart Kidney Liver Lung Muscle Ovary Placenta Testis
ENST00000261799 96.605±0.00 26.757±0.00 3.571±0.00 4.105±3.53 19.139±13.16 14.773±13.40 12.764±0.00 16.143±0.00 1.603±0.26 24.501±20.63 5.691±4.96 25.661±23.04 31.355±10.65 23.359±17.85

Conserved Regions

Region IDSub-RegionRegion TypePosition
CIL_00091Q CIL_00091Q_0001 VISTA 5:150006686-150608670

Gene Ontology

GO IDEvidence TypeGO Description
GO:0001701 IEA in utero embryonic development
GO:0001822 IEA kidney development
GO:0001894 IEA tissue homeostasis
GO:0004672 IEA protein kinase activity
GO:0004713 IDA:IEA protein tyrosine kinase activity
GO:0004714 IEA transmembrane receptor protein tyrosine kinase activity
GO:0004871 IEA signal transducer activity
GO:0004992 TAS platelet activating factor receptor activity
GO:0005017 TAS platelet-derived growth factor-activated receptor activity
GO:0005019 IDA platelet-derived growth factor beta-receptor activity
GO:0005102 IPI receptor binding
GO:0005161 IPI platelet-derived growth factor receptor binding
GO:0005515 IPI:IEA protein binding
GO:0005524 IEA ATP binding
GO:0005634 ISS nucleus
GO:0005737 ISS cytoplasm
GO:0005764 IEA lysosome
GO:0005886 TAS plasma membrane
GO:0005925 IDA focal adhesion
GO:0006024 IEA glycosaminoglycan biosynthetic process
GO:0006468 IEA protein phosphorylation
GO:0006807 IEA nitrogen compound metabolic process
GO:0007165 IDA signal transduction
GO:0007169 IEA transmembrane receptor protein tyrosine kinase signaling pathway
GO:0007173 TAS epidermal growth factor receptor signaling pathway
GO:0007186 TAS G-protein coupled receptor signaling pathway
GO:0008284 IMP positive regulation of cell proliferation
GO:0008543 TAS fibroblast growth factor receptor signaling pathway
GO:0009636 IEA response to toxic substance
GO:0009986 IEA cell surface
GO:0010863 IDA positive regulation of phospholipase C activity
GO:0014068 ISS positive regulation of phosphatidylinositol 3-kinase signaling
GO:0014070 IEA response to organic cyclic compound
GO:0014911 ISS positive regulation of smooth muscle cell migration
GO:0016020 IDA membrane
GO:0016021 IEA integral component of membrane
GO:0016301 IEA kinase activity
GO:0016324 ISS apical plasma membrane
GO:0016477 IMP cell migration
GO:0016772 IEA transferase activity, transferring phosphorus-containing groups
GO:0018108 IDA peptidyl-tyrosine phosphorylation
GO:0019901 IPI protein kinase binding
GO:0030325 IEA adrenal gland development
GO:0030335 IDA positive regulation of cell migration
GO:0031226 IDA intrinsic component of plasma membrane
GO:0031410 IEA cytoplasmic vesicle
GO:0032355 IEA response to estradiol
GO:0032516 IDA positive regulation of phosphoprotein phosphatase activity
GO:0032526 IEA response to retinoic acid
GO:0032956 ISS regulation of actin cytoskeleton organization
GO:0032967 IEA positive regulation of collagen biosynthetic process
GO:0033993 IEA response to lipid
GO:0034405 IEA response to fluid shear stress
GO:0035441 ISS cell migration involved in vasculogenesis
GO:0035556 IEA intracellular signal transduction
GO:0035789 IEA metanephric mesenchymal cell migration
GO:0035791 IMP platelet-derived growth factor receptor-beta signaling pathway
GO:0035793 ISS positive regulation of metanephric mesenchymal cell migration by platelet-derived growth factor receptor-beta signaling pathway
GO:0035909 ISS aorta morphogenesis
GO:0036120 TAS cellular response to platelet-derived growth factor stimulus
GO:0038085 IPI vascular endothelial growth factor binding
GO:0038091 IDA positive regulation of cell proliferation by VEGF-activated platelet derived growth factor receptor signaling pathway
GO:0038095 TAS Fc-epsilon receptor signaling pathway
GO:0042060 IEA wound healing
GO:0042542 IEA response to hydrogen peroxide
GO:0043066 IEA negative regulation of apoptotic process
GO:0043406 ISS positive regulation of MAP kinase activity
GO:0043548 IEA phosphatidylinositol 3-kinase binding
GO:0043552 IDA positive regulation of phosphatidylinositol 3-kinase activity
GO:0043627 IEA response to estrogen
GO:0045087 TAS innate immune response
GO:0045840 ISS positive regulation of mitosis
GO:0046488 IMP phosphatidylinositol metabolic process
GO:0046777 IDA protein autophosphorylation
GO:0048008 IDA platelet-derived growth factor receptor signaling pathway
GO:0048011 TAS neurotrophin TRK receptor signaling pathway
GO:0048015 IMP phosphatidylinositol-mediated signaling
GO:0048407 IPI platelet-derived growth factor binding
GO:0048661 ISS positive regulation of smooth muscle cell proliferation
GO:0048705 IEA skeletal system morphogenesis
GO:0048745 IEA smooth muscle tissue development
GO:0048839 IEA inner ear development
GO:0050730 IEA regulation of peptidyl-tyrosine phosphorylation
GO:0050921 ISS positive regulation of chemotaxis
GO:0055003 ISS cardiac myofibril assembly
GO:0055093 IEA response to hyperoxia
GO:0060326 IDA cell chemotaxis
GO:0060981 ISS cell migration involved in coronary angiogenesis
GO:0061298 ISS retina vasculature development in camera-type eye
GO:0070062 IDA extracellular vesicular exosome
GO:0070374 ISS positive regulation of ERK1 and ERK2 cascade
GO:0071670 ISS smooth muscle cell chemotaxis
GO:0072075 IEA metanephric mesenchyme development
GO:0072262 ISS metanephric glomerular mesangial cell proliferation involved in metanephros development
GO:0072275 IEA metanephric glomerulus morphogenesis
GO:0072277 ISS metanephric glomerular capillary formation
GO:0072278 IEA metanephric comma-shaped body morphogenesis
GO:0072284 IEA metanephric S-shaped body morphogenesis
GO:0090280 ISS positive regulation of calcium ion import
GO:2000379 ISS positive regulation of reactive oxygen species metabolic process
GO:2000573 ISS positive regulation of DNA biosynthetic process

Homologs

ENSEMBL Accession Gene Name Biotype Species E-Value Bit Score
ENSMUST00000025522 Pdgfrb-001 protein_coding Mus_musculus 0 3134
ENSMUST00000115274 Pdgfrb-002 protein_coding Mus_musculus 0 3120

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