C-It-Loci: A knowledge database for tissue-enriched loci.

Institute of Cardiovascular Regeneration, Goethe-University Frankfurt am Main

Transcript Info
Description: SMAD specific E3 ubiquitin protein ligase 2
Transcript Accession Transcript Name Contained in Gene Tax ID Strand Position Biotype
ENST00000262435 SMURF2-001 ENSG00000108854 9606 - 17:64545365-64662068 protein_coding

Expression Patterns

No expression data.

Conserved Regions

Region IDSub-RegionRegion TypePosition
CIL_00012F CIL_00012F_0001 CGP 17:64499616-64542461
CIL_0006GQ CIL_0006GQ_0001 CGP 17:64506588-64662068

Gene Ontology

GO IDEvidence TypeGO Description
GO:0000122 TAS negative regulation of transcription from RNA polymerase II promoter
GO:0000151 IDA ubiquitin ligase complex
GO:0004842 IDA:IEA ubiquitin-protein transferase activity
GO:0005160 IEA transforming growth factor beta receptor binding
GO:0005515 IPI:IEA protein binding
GO:0005634 IBA nucleus
GO:0005654 TAS nucleoplasm
GO:0005737 IBA cytoplasm
GO:0005829 TAS cytosol
GO:0005886 IEA plasma membrane
GO:0006351 TAS transcription, DNA-templated
GO:0006367 TAS transcription initiation from RNA polymerase II promoter
GO:0006511 IDA ubiquitin-dependent protein catabolic process
GO:0007179 IBA transforming growth factor beta receptor signaling pathway
GO:0010467 TAS gene expression
GO:0016874 IEA ligase activity
GO:0017015 NAS regulation of transforming growth factor beta receptor signaling pathway
GO:0030509 TAS BMP signaling pathway
GO:0030512 TAS negative regulation of transforming growth factor beta receptor signaling pathway
GO:0030579 IDA ubiquitin-dependent SMAD protein catabolic process
GO:0042787 IBA protein ubiquitination involved in ubiquitin-dependent protein catabolic process
GO:0042802 IPI identical protein binding
GO:0045892 NAS negative regulation of transcription, DNA-templated
GO:0046332 IPI SMAD binding

Homologs

ENSEMBL Accession Gene Name Biotype Species E-Value Bit Score
ENSMUST00000092517 Smurf2-002 protein_coding Mus_musculus 0 3554
ENSMUST00000103067 Smurf2-001 protein_coding Mus_musculus 0 3354
ENSMUST00000167787 Smurf2-201 protein_coding Mus_musculus 0 3203
ENSMUST00000139297 Smurf2-003 processed_transcript Mus_musculus 0 2756
ENSMUST00000144027 Smurf2-004 processed_transcript Mus_musculus 0 800

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