C-It-Loci: A knowledge database for tissue-enriched loci.

Institute of Cardiovascular Regeneration, Goethe-University Frankfurt am Main

Gene Info

Description: SMAD specific E3 ubiquitin protein ligase 2
Gene AccessionGene NameTax IDStrandPositionGene Biotype
ENSG00000108854 SMURF2 9606 - 17:64542295-64662068 protein_coding
  Transcript Accession Transcript Name Position Transcript Biotype
  ENST00000262435 SMURF2-001 64545365-64662068 protein_coding
  ENST00000578200 SMURF2-007 64560840-64660862 processed_transcript
  ENST00000578386 SMURF2-004 64545068-64661928 nonsense_mediated_decay
  ENST00000580072 SMURF2-006 64557641-64563165 retained_intron
  ENST00000580246 SMURF2-005 64593015-64598445 retained_intron
  ENST00000582081 SMURF2-003 64542295-64661897 nonsense_mediated_decay
  ENST00000585301 SMURF2-002 64554881-64661912 protein_coding

Expression Patterns

Heat Map
Numeric Values
Transcript'; ColonENST00000582081
Transcript ID Colon
ENST00000582081 3.900±0.00

Conserved Regions

Region IDSub-RegionRegion TypePosition
CIL_00012F CIL_00012F_0001 CGP 17:64499616-64542461
CIL_0006GQ CIL_0006GQ_0001 CGP 17:64506588-64662068

Gene Ontology
GO IDEvidence TypeGO Description
GO:0000122 TAS negative regulation of transcription from RNA polymerase II promoter
GO:0000151 IDA ubiquitin ligase complex
GO:0004842 IDA:IEA ubiquitin-protein transferase activity
GO:0005160 IEA transforming growth factor beta receptor binding
GO:0005515 IPI:IEA protein binding
GO:0005634 IBA nucleus
GO:0005654 TAS nucleoplasm
GO:0005737 IBA cytoplasm
GO:0005829 TAS cytosol
GO:0005886 IEA plasma membrane
GO:0006351 TAS transcription, DNA-templated
GO:0006367 TAS transcription initiation from RNA polymerase II promoter
GO:0006511 IDA ubiquitin-dependent protein catabolic process
GO:0007179 IBA transforming growth factor beta receptor signaling pathway
GO:0010467 TAS gene expression
GO:0016567 IEA protein ubiquitination
GO:0016874 IEA ligase activity
GO:0017015 NAS regulation of transforming growth factor beta receptor signaling pathway
GO:0030509 TAS BMP signaling pathway
GO:0030512 TAS negative regulation of transforming growth factor beta receptor signaling pathway
GO:0030579 IDA ubiquitin-dependent SMAD protein catabolic process
GO:0042787 IBA protein ubiquitination involved in ubiquitin-dependent protein catabolic process
GO:0042802 IPI identical protein binding
GO:0045892 NAS negative regulation of transcription, DNA-templated
GO:0046332 IPI SMAD binding

Homologs

ENSEMBL Accession Gene Name Description Biotype Species
ENSDARG00000038067 smurf2 SMAD specific E3 ubiquitin protein ligase 2 protein_coding Danio_rerio
ENSMUSG00000018363 Smurf2 SMAD specific E3 ubiquitin protein ligase 2 protein_coding Mus_musculus

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