C-It-Loci: A knowledge database for tissue-enriched loci.

Institute of Cardiovascular Regeneration, Goethe-University Frankfurt am Main

Transcript Info
Description: interleukin 1, beta
Transcript Accession Transcript Name Contained in Gene Tax ID Strand Position Biotype
ENST00000263341 IL1B-001 ENSG00000125538 9606 - 2:112829751-112836903 protein_coding

Expression Patterns

Heat Map
Numeric Values
Transcript'; AdiposeAdrenalBladderBrainBreastColonHeartKidneyLiverLungMuscleOvaryPlacentaTestisENST00000263341
Transcript ID Adipose Adrenal Bladder Brain Breast Colon Heart Kidney Liver Lung Muscle Ovary Placenta Testis
ENST00000263341 0.050±0.00 3.610±0.00 0.169±0.00 1.251±0.54 0.989±0.00 0.255±0.07 0.510±0.00 0.627±0.46 0.290±0.24 6.367±1.59 0.267±0.00 2.215±0.55 6.978±3.11 0.340±0.00

Conserved Regions

Region IDSub-RegionRegion TypePosition
CIL_00018X CIL_00018X_0001 CGP 2:112773915-112836903

Gene Ontology

GO IDEvidence TypeGO Description
GO:0000165 IMP MAPK cascade
GO:0000187 IDA activation of MAPK activity
GO:0001660 IEA fever generation
GO:0001934 IDA positive regulation of protein phosphorylation
GO:0002711 IC positive regulation of T cell mediated immunity
GO:0005125 IDA cytokine activity
GO:0005149 IEA:NAS interleukin-1 receptor binding
GO:0005576 NAS extracellular region
GO:0005615 IDA:IEA extracellular space
GO:0005829 TAS cytosol
GO:0006915 TAS apoptotic process
GO:0006954 IEA:IDA inflammatory response
GO:0006955 IEA immune response
GO:0007165 TAS signal transduction
GO:0007267 TAS cell-cell signaling
GO:0007566 TAS embryo implantation
GO:0008285 IDA negative regulation of cell proliferation
GO:0009743 IEA response to carbohydrate
GO:0010575 ISS positive regulation vascular endothelial growth factor production
GO:0010628 IDA positive regulation of gene expression
GO:0010829 ISS negative regulation of glucose transport
GO:0014805 NAS smooth muscle adaptation
GO:0019221 IDA cytokine-mediated signaling pathway
GO:0019904 IPI protein domain specific binding
GO:0030141 IEA secretory granule
GO:0030213 IDA hyaluronan biosynthetic process
GO:0030593 IEA neutrophil chemotaxis
GO:0030730 IDA sequestering of triglyceride
GO:0030949 IC positive regulation of vascular endothelial growth factor receptor signaling pathway
GO:0031622 ISS positive regulation of fever generation
GO:0031663 IDA lipopolysaccharide-mediated signaling pathway
GO:0031982 IEA vesicle
GO:0032308 ISS positive regulation of prostaglandin secretion
GO:0032496 IEA response to lipopolysaccharide
GO:0032611 IEA interleukin-1 beta production
GO:0032725 IDA positive regulation of granulocyte macrophage colony-stimulating factor production
GO:0032729 IDA positive regulation of interferon-gamma production
GO:0032755 TAS positive regulation of interleukin-6 production
GO:0032757 IDA positive regulation of interleukin-8 production
GO:0033129 NAS positive regulation of histone phosphorylation
GO:0033198 IEA response to ATP
GO:0034116 IDA positive regulation of heterotypic cell-cell adhesion
GO:0035066 NAS positive regulation of histone acetylation
GO:0035234 IEA ectopic germ cell programmed cell death
GO:0035505 IDA positive regulation of myosin light chain kinase activity
GO:0035690 IDA cellular response to drug
GO:0042102 IDA positive regulation of T cell proliferation
GO:0042346 IDA positive regulation of NF-kappaB import into nucleus
GO:0043122 IDA regulation of I-kappaB kinase/NF-kappaB signaling
GO:0043123 IEA positive regulation of I-kappaB kinase/NF-kappaB signaling
GO:0043407 ISS negative regulation of MAP kinase activity
GO:0043491 IMP protein kinase B signaling
GO:0045080 IEA positive regulation of chemokine biosynthetic process
GO:0045086 IMP positive regulation of interleukin-2 biosynthetic process
GO:0045410 IEA positive regulation of interleukin-6 biosynthetic process
GO:0045429 IDA positive regulation of nitric oxide biosynthetic process
GO:0045766 ISS positive regulation of angiogenesis
GO:0045833 ISS negative regulation of lipid metabolic process
GO:0045840 IMP positive regulation of mitosis
GO:0045893 IDA positive regulation of transcription, DNA-templated
GO:0045944 IEA positive regulation of transcription from RNA polymerase II promoter
GO:0046330 IEA positive regulation of JNK cascade
GO:0046627 ISS negative regulation of insulin receptor signaling pathway
GO:0046827 NAS positive regulation of protein export from nucleus
GO:0050796 IDA regulation of insulin secretion
GO:0050900 IEA leukocyte migration
GO:0050995 IDA negative regulation of lipid catabolic process
GO:0050996 ISS positive regulation of lipid catabolic process
GO:0051044 IDA positive regulation of membrane protein ectodomain proteolysis
GO:0051091 IDA positive regulation of sequence-specific DNA binding transcription factor activity
GO:0051092 IDA positive regulation of NF-kappaB transcription factor activity
GO:0051781 IEA positive regulation of cell division
GO:0060355 NAS positive regulation of cell adhesion molecule production
GO:0060559 IDA positive regulation of calcidiol 1-monooxygenase activity
GO:0070164 ISS negative regulation of adiponectin secretion
GO:0070487 IDA monocyte aggregation
GO:0071260 IEP cellular response to mechanical stimulus
GO:0071310 IDA cellular response to organic substance
GO:0071407 IDA cellular response to organic cyclic compound
GO:0071639 IDA positive regulation of monocyte chemotactic protein-1 production
GO:0097192 IEA extrinsic apoptotic signaling pathway in absence of ligand
GO:2001240 IDA negative regulation of extrinsic apoptotic signaling pathway in absence of ligand

Homologs

ENSEMBL Accession Gene Name Biotype Species E-Value Bit Score
ENSMUST00000028881 Il1b-001 protein_coding Mus_musculus 0 569
ENSMUST00000141979 Il1b-002 processed_transcript Mus_musculus 0 268
ENSDART00000123399 gcfc2-001 protein_coding Danio_rerio 0.00005 55

Loading