C-It-Loci: A knowledge database for tissue-enriched loci.

Institute of Cardiovascular Regeneration, Goethe-University Frankfurt am Main

Transcript Info
Description: phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit alpha
Transcript Accession Transcript Name Contained in Gene Tax ID Strand Position Biotype
ENST00000263967 PIK3CA-001 ENSG00000121879 9606 + 3:179148523-179240093 protein_coding

Expression Patterns

Heat Map
Numeric Values
Transcript'; AdrenalBrainColonHeartKidneyLiverLungMuscleOvaryPlacentaTestisENST00000263967
Transcript ID Adrenal Brain Colon Heart Kidney Liver Lung Muscle Ovary Placenta Testis
ENST00000263967 1.713±0.00 0.970±0.08 2.872±0.25 2.242±0.00 2.372±0.00 2.398±1.77 2.959±0.90 1.174±0.61 1.785±0.25 2.008±0.72 2.764±0.01

Conserved Regions

Region IDSub-RegionRegion TypePosition
CIL_0001FJ CIL_0001FJ_0001 CGP 3:179017223-179240093
CIL_0001FK CIL_0001FK_0001 CGP 3:179148114-179267002

Gene Ontology

GO IDEvidence TypeGO Description
GO:0001525 IEA angiogenesis
GO:0001944 TAS vasculature development
GO:0004674 IEA protein serine/threonine kinase activity
GO:0005488 IEA binding
GO:0005515 IPI:IEA protein binding
GO:0005524 IEA ATP binding
GO:0005829 TAS cytosol
GO:0005886 IBA plasma membrane
GO:0005942 ISS phosphatidylinositol 3-kinase complex
GO:0005943 IDA phosphatidylinositol 3-kinase complex, class IA
GO:0006006 IEA glucose metabolic process
GO:0006468 IEA protein phosphorylation
GO:0006644 TAS phospholipid metabolic process
GO:0006661 TAS phosphatidylinositol biosynthetic process
GO:0007173 TAS epidermal growth factor receptor signaling pathway
GO:0007596 TAS blood coagulation
GO:0008286 TAS insulin receptor signaling pathway
GO:0008543 TAS fibroblast growth factor receptor signaling pathway
GO:0016301 TAS kinase activity
GO:0016303 IDA 1-phosphatidylinositol-3-kinase activity
GO:0016772 IEA transferase activity, transferring phosphorus-containing groups
GO:0016773 IEA phosphotransferase activity, alcohol group as acceptor
GO:0030027 IEA lamellipodium
GO:0030168 TAS platelet activation
GO:0030295 IEA protein kinase activator activity
GO:0031295 TAS T cell costimulation
GO:0033138 IEA positive regulation of peptidyl-serine phosphorylation
GO:0035004 ISS phosphatidylinositol 3-kinase activity
GO:0035005 IBA 1-phosphatidylinositol-4-phosphate 3-kinase activity
GO:0036092 IEA phosphatidylinositol-3-phosphate biosynthetic process
GO:0038028 TAS insulin receptor signaling pathway via phosphatidylinositol 3-kinase
GO:0038095 TAS Fc-epsilon receptor signaling pathway
GO:0038096 TAS Fc-gamma receptor signaling pathway involved in phagocytosis
GO:0040014 IEA regulation of multicellular organism growth
GO:0043491 IEA protein kinase B signaling
GO:0043524 IEA negative regulation of neuron apoptotic process
GO:0043542 TAS endothelial cell migration
GO:0043560 IEA insulin receptor substrate binding
GO:0044029 IEA hypomethylation of CpG island
GO:0044281 TAS small molecule metabolic process
GO:0045087 TAS innate immune response
GO:0045860 IEA positive regulation of protein kinase activity
GO:0046854 ISS phosphatidylinositol phosphorylation
GO:0046934 TAS phosphatidylinositol-4,5-bisphosphate 3-kinase activity
GO:0048011 TAS neurotrophin TRK receptor signaling pathway
GO:0048015 IEA:TAS phosphatidylinositol-mediated signaling
GO:0050852 TAS T cell receptor signaling pathway
GO:0050900 TAS leukocyte migration
GO:0060048 TAS cardiac muscle contraction
GO:2000270 IEA negative regulation of fibroblast apoptotic process
GO:2000653 IEA regulation of genetic imprinting
GO:2000811 IMP negative regulation of anoikis

Homologs

ENSEMBL Accession Gene Name Biotype Species E-Value Bit Score
ENSMUST00000029201 Pik3ca-201 protein_coding Mus_musculus 0 4835
ENSMUST00000108243 Pik3ca-001 protein_coding Mus_musculus 0 4835
ENSMUST00000108242 Pik3ca-002 protein_coding Mus_musculus 0 4311
ENSDART00000112973 PIK3CA (2 of 2)-201 protein_coding Danio_rerio 0 1783
ENSDART00000114004 PIK3CA (1 of 2)-201 protein_coding Danio_rerio 0 1760

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