C-It-Loci: A knowledge database for tissue-enriched loci.

Institute of Cardiovascular Regeneration, Goethe-University Frankfurt am Main

Transcript Info
Description: IQ motif containing GTPase activating protein 1
Transcript Accession Transcript Name Contained in Gene Tax ID Strand Position Biotype
ENST00000268182 IQGAP1-001 ENSG00000140575 9606 + 15:90388218-90502243 protein_coding

Expression Patterns

Heat Map
Numeric Values
Transcript'; AdiposeAdrenalBladderBrainBreastColonHeartKidneyLiverLungMuscleOvaryPlacentaTestisENST00000268182
Transcript ID Adipose Adrenal Bladder Brain Breast Colon Heart Kidney Liver Lung Muscle Ovary Placenta Testis
ENST00000268182 37.188±0.00 15.776±0.00 10.044±0.00 5.054±2.28 20.617±4.75 23.039±5.96 5.509±1.79 3.897±0.94 14.710±12.66 30.982±4.46 5.363±0.00 19.881±7.44 22.792±5.95 6.922±1.89

Conserved Regions

Region IDSub-RegionRegion TypePosition
CIL_0008FE CIL_0008FE_0001 VISTA 15:90100149-90701385

Gene Ontology

GO IDEvidence TypeGO Description
GO:0001817 IEA regulation of cytokine production
GO:0005095 TAS GTPase inhibitor activity
GO:0005096 TAS GTPase activator activity
GO:0005099 IEA Ras GTPase activator activity
GO:0005509 TAS calcium ion binding
GO:0005515 IPI:IEA protein binding
GO:0005516 IPI calmodulin binding
GO:0005547 IDA phosphatidylinositol-3,4,5-trisphosphate binding
GO:0005622 IEA intracellular
GO:0005634 IDA nucleus
GO:0005737 IDA cytoplasm
GO:0005874 IDA microtubule
GO:0005884 TAS actin filament
GO:0005886 IDA plasma membrane
GO:0005911 IEA cell-cell junction
GO:0005925 IDA focal adhesion
GO:0006112 TAS energy reserve metabolic process
GO:0007165 TAS:IEA signal transduction
GO:0007173 IMP epidermal growth factor receptor signaling pathway
GO:0007264 IEA small GTPase mediated signal transduction
GO:0008543 IEA fibroblast growth factor receptor signaling pathway
GO:0015629 ISS actin cytoskeleton
GO:0015630 ISS microtubule cytoskeleton
GO:0016020 IEA membrane
GO:0016328 IEA lateral plasma membrane
GO:0017048 IEA Rho GTPase binding
GO:0019901 IPI protein kinase binding
GO:0019903 IPI protein phosphatase binding
GO:0030054 IDA cell junction
GO:0030424 ISS axon
GO:0030426 ISS growth cone
GO:0030496 IDA midbody
GO:0030529 IEA ribonucleoprotein complex
GO:0031234 IDA extrinsic component of cytoplasmic side of plasma membrane
GO:0031252 IEA cell leading edge
GO:0032318 IEA regulation of Ras GTPase activity
GO:0032320 IEA positive regulation of Ras GTPase activity
GO:0032403 IEA protein complex binding
GO:0035305 IEA negative regulation of dephosphorylation
GO:0036057 ISS slit diaphragm
GO:0036120 IEA cellular response to platelet-derived growth factor stimulus
GO:0036464 IDA cytoplasmic ribonucleoprotein granule
GO:0043005 ISS neuron projection
GO:0043086 TAS negative regulation of catalytic activity
GO:0043234 IEA protein complex
GO:0043539 IDA protein serine/threonine kinase activator activity
GO:0043547 TAS positive regulation of GTPase activity
GO:0044281 TAS small molecule metabolic process
GO:0044344 IEA cellular response to fibroblast growth factor stimulus
GO:0045860 IMP positive regulation of protein kinase activity
GO:0048008 IEA platelet-derived growth factor receptor signaling pathway
GO:0048365 IEA Rac GTPase binding
GO:0050796 TAS regulation of insulin secretion
GO:0070062 IDA extracellular vesicular exosome
GO:0071277 IDA cellular response to calcium ion
GO:0071364 IMP cellular response to epidermal growth factor stimulus
GO:0071902 IDA positive regulation of protein serine/threonine kinase activity
GO:0072015 ISS glomerular visceral epithelial cell development
GO:1990138 IMP neuron projection extension

Homologs

ENSEMBL Accession Gene Name Biotype Species E-Value Bit Score
ENSMUST00000167377 Iqgap1-201 protein_coding Mus_musculus 0 6139

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