C-It-Loci: A knowledge database for tissue-enriched loci.

Institute of Cardiovascular Regeneration, Goethe-University Frankfurt am Main

Transcript Info
Description: IQ motif containing GTPase activating protein 1
Transcript Accession Transcript Name Contained in Gene Tax ID Strand Position Biotype
ENSMUST00000167377 Iqgap1-201 ENSMUSG00000030536 10090 - 7:80711583-80803331 protein_coding

Expression Patterns

Heat Map
Numeric Values
Transcript'; AdiposeAdrenalBladderBrainBreastColonHeartKidneyLiverLungMuscleOvaryPlacentaTestisENSMUST00000167377
Transcript ID Adipose Adrenal Bladder Brain Breast Colon Heart Kidney Liver Lung Muscle Ovary Placenta Testis
ENSMUST00000167377 33.719±10.96 18.147±1.87 24.134±0.44 3.627±0.94 32.474±3.27 50.555±1.41 6.881±1.29 15.483±2.74 3.180±1.93 71.620±17.04 1.691±0.75 25.698±4.33 45.558±19.45 3.667±1.47

Conserved Regions

Region IDSub-RegionRegion TypePosition
CIL_0008AY CIL_0008AY_0002 VISTA 7:80145068-80746500
CIL_0008FE CIL_0008FE_0002 VISTA 7:80488938-81090184
CIL_00073S CIL_00073S_0002 CGP 7:80586627-80803331

Gene Ontology

GO IDEvidence TypeGO Description
GO:0001817 IMP regulation of cytokine production
GO:0005099 IEA Ras GTPase activator activity
GO:0005515 IPI protein binding
GO:0005516 IEA calmodulin binding
GO:0005547 ISS phosphatidylinositol-3,4,5-trisphosphate binding
GO:0005634 IEA nucleus
GO:0005737 IDA cytoplasm
GO:0005874 IEA microtubule
GO:0005886 IEA plasma membrane
GO:0005911 IDA cell-cell junction
GO:0005925 IEA focal adhesion
GO:0007173 IMP epidermal growth factor receptor signaling pathway
GO:0007264 IEA small GTPase mediated signal transduction
GO:0008543 IMP fibroblast growth factor receptor signaling pathway
GO:0015629 ISS actin cytoskeleton
GO:0015630 ISS microtubule cytoskeleton
GO:0016020 IDA membrane
GO:0016328 IDA lateral plasma membrane
GO:0017048 IPI Rho GTPase binding
GO:0019901 IEA protein kinase binding
GO:0019903 IEA protein phosphatase binding
GO:0030054 IEA cell junction
GO:0030424 ISS axon
GO:0030426 ISS growth cone
GO:0030496 IEA midbody
GO:0030529 IDA ribonucleoprotein complex
GO:0031234 ISS extrinsic component of cytoplasmic side of plasma membrane
GO:0031252 IGI cell leading edge
GO:0032320 IEA positive regulation of Ras GTPase activity
GO:0032403 IEA protein complex binding
GO:0035305 IGI negative regulation of dephosphorylation
GO:0036057 ISS slit diaphragm
GO:0036120 IMP cellular response to platelet-derived growth factor stimulus
GO:0036464 IEA cytoplasmic ribonucleoprotein granule
GO:0043005 ISS neuron projection
GO:0043234 IEA protein complex
GO:0043539 IEA protein serine/threonine kinase activator activity
GO:0044344 IMP cellular response to fibroblast growth factor stimulus
GO:0045860 IMP positive regulation of protein kinase activity
GO:0048008 IMP platelet-derived growth factor receptor signaling pathway
GO:0048365 IPI Rac GTPase binding
GO:0070062 IEA extracellular vesicular exosome
GO:0071277 IEA cellular response to calcium ion
GO:0071364 IMP cellular response to epidermal growth factor stimulus
GO:0071902 IEA positive regulation of protein serine/threonine kinase activity
GO:0072015 ISS glomerular visceral epithelial cell development
GO:1990138 IEA neuron projection extension

Homologs

ENSEMBL Accession Gene Name Biotype Species E-Value Bit Score
ENSDART00000110283 iqgap1-201 protein_coding Danio_rerio 0 1247
ENST00000268182 IQGAP1-001 protein_coding Homo_sapiens 0 6139
ENST00000361170 IQGAP3-001 protein_coding Homo_sapiens 0 355
ENST00000491900 IQGAP3-002 nonsense_mediated_decay Homo_sapiens 0 355
ENST00000558003 IQGAP1-009 retained_intron Homo_sapiens 0 211
ENST00000558491 IQGAP1-013 retained_intron Homo_sapiens 0 270
ENST00000558957 IQGAP1-002 retained_intron Homo_sapiens 0 484
ENST00000559031 IQGAP1-015 retained_intron Homo_sapiens 0 558
ENST00000559674 IQGAP1-017 retained_intron Homo_sapiens 0 669
ENST00000559682 IQGAP1-007 retained_intron Homo_sapiens 0 268
ENST00000560218 IQGAP1-012 retained_intron Homo_sapiens 0 494
ENST00000560418 IQGAP1-006 protein_coding Homo_sapiens 0 326
ENST00000560738 IQGAP1-004 protein_coding Homo_sapiens 0 3989
ENST00000561086 IQGAP1-003 retained_intron Homo_sapiens 0 357
ENST00000561132 IQGAP1-016 retained_intron Homo_sapiens 0 603
ENST00000561461 IQGAP1-014 retained_intron Homo_sapiens 0 617

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