C-It-Loci: A knowledge database for tissue-enriched loci.

Institute of Cardiovascular Regeneration, Goethe-University Frankfurt am Main

Transcript Info
Description: transforming growth factor, beta receptor II (70/80kDa)
Transcript Accession Transcript Name Contained in Gene Tax ID Strand Position Biotype
ENST00000295754 TGFBR2-001 ENSG00000163513 9606 + 3:30606502-30694134 protein_coding

Expression Patterns

Heat Map
Numeric Values
Transcript'; AdiposeBladderBrainBreastColonHeartKidneyLiverLungMuscleOvaryPlacentaTestisENST00000295754
Transcript ID Adipose Bladder Brain Breast Colon Heart Kidney Liver Lung Muscle Ovary Placenta Testis
ENST00000295754 57.748±0.00 8.620±0.00 1.808±0.72 35.107±13.51 49.209±36.36 25.213±18.29 25.522±17.02 14.379±2.14 41.600±13.66 7.559±4.45 15.715±4.82 23.578±4.05 11.636±7.27

Conserved Regions

Gene is not located within a conserved region.

Gene Ontology

GO IDEvidence TypeGO Description
GO:0001568 TAS blood vessel development
GO:0001569 ISS patterning of blood vessels
GO:0001570 ISS vasculogenesis
GO:0002053 ISS positive regulation of mesenchymal cell proliferation
GO:0002651 ISS positive regulation of tolerance induction to self antigen
GO:0002663 ISS positive regulation of B cell tolerance induction
GO:0002666 ISS positive regulation of T cell tolerance induction
GO:0004672 IEA protein kinase activity
GO:0004674 IEA protein serine/threonine kinase activity
GO:0004675 IDA transmembrane receptor protein serine/threonine kinase activity
GO:0004702 IEA receptor signaling protein serine/threonine kinase activity
GO:0004713 IEA protein tyrosine kinase activity
GO:0004872 IEA receptor activity
GO:0005024 IC transforming growth factor beta-activated receptor activity
GO:0005026 IEA transforming growth factor beta receptor activity, type II
GO:0005515 IPI protein binding
GO:0005524 IEA ATP binding
GO:0005539 IDA glycosaminoglycan binding
GO:0005829 TAS cytosol
GO:0005886 TAS plasma membrane
GO:0005901 IDA caveola
GO:0006468 IDA:IEA protein phosphorylation
GO:0006915 IDA apoptotic process
GO:0007179 IMP:IEA transforming growth factor beta receptor signaling pathway
GO:0007420 ISS brain development
GO:0007507 ISS heart development
GO:0008284 TAS positive regulation of cell proliferation
GO:0009897 IDA external side of plasma membrane
GO:0016020 IEA membrane
GO:0016021 IDA:IEA integral component of membrane
GO:0016772 IEA transferase activity, transferring phosphorus-containing groups
GO:0018105 IDA peptidyl-serine phosphorylation
GO:0018107 IDA peptidyl-threonine phosphorylation
GO:0023014 IEA signal transduction by phosphorylation
GO:0030512 TAS negative regulation of transforming growth factor beta receptor signaling pathway
GO:0032147 ISS activation of protein kinase activity
GO:0034713 IDA type I transforming growth factor beta receptor binding
GO:0034714 IDA type III transforming growth factor beta receptor binding
GO:0035162 ISS embryonic hemopoiesis
GO:0042127 ISS regulation of cell proliferation
GO:0042493 IDA response to drug
GO:0043011 ISS myeloid dendritic cell differentiation
GO:0043235 IDA:IEA receptor complex
GO:0046332 IDA SMAD binding
GO:0046872 IEA metal ion binding
GO:0048701 ISS embryonic cranial skeleton morphogenesis
GO:0050431 IDA transforming growth factor beta binding
GO:0051138 ISS positive regulation of NK T cell differentiation
GO:0060021 ISS palate development
GO:0060389 IDA pathway-restricted SMAD protein phosphorylation
GO:0070022 IC transforming growth factor beta receptor homodimeric complex
GO:0070723 IDA response to cholesterol
GO:2000379 IMP positive regulation of reactive oxygen species metabolic process

Homologs

ENSEMBL Accession Gene Name Biotype Species E-Value Bit Score
ENSMUST00000035014 Tgfbr2-201 protein_coding Mus_musculus 0 2089
ENSMUST00000061101 Tgfbr2-202 protein_coding Mus_musculus 0 1912

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