C-It-Loci: A knowledge database for tissue-enriched loci.

Institute of Cardiovascular Regeneration, Goethe-University Frankfurt am Main

Transcript Info
Description: transforming growth factor, beta receptor II
Transcript Accession Transcript Name Contained in Gene Tax ID Strand Position Biotype
ENSMUST00000061101 Tgfbr2-202 ENSMUSG00000032440 10090 - 9:116087698-116175363 protein_coding

Expression Patterns

Heat Map
Numeric Values
Transcript'; AdiposeAdrenalBladderBrainBreastColonHeartKidneyLiverLungMuscleOvaryPlacentaTestisENSMUST00000061101
Transcript ID Adipose Adrenal Bladder Brain Breast Colon Heart Kidney Liver Lung Muscle Ovary Placenta Testis
ENSMUST00000061101 26.087±6.87 8.472±1.76 19.296±0.20 1.438±0.11 24.549±1.41 10.937±0.97 5.591±0.53 8.620±1.31 1.248±0.63 28.549±0.08 1.760±0.56 8.532±2.65 5.715±2.09 0.423±0.06

Conserved Regions

Region IDSub-RegionRegion TypePosition
CIL_00028F CIL_00028F_0002 CGP 9:116087698-117629913

Gene Ontology

GO IDEvidence TypeGO Description
GO:0001569 IMP patterning of blood vessels
GO:0001570 IMP vasculogenesis
GO:0001701 IMP in utero embryonic development
GO:0002053 IMP positive regulation of mesenchymal cell proliferation
GO:0002088 IMP lens development in camera-type eye
GO:0002651 IMP positive regulation of tolerance induction to self antigen
GO:0002663 IMP positive regulation of B cell tolerance induction
GO:0002666 IMP positive regulation of T cell tolerance induction
GO:0003417 IGI growth plate cartilage development
GO:0003430 IMP growth plate cartilage chondrocyte growth
GO:0004675 IEA transmembrane receptor protein serine/threonine kinase activity
GO:0004702 IEA receptor signaling protein serine/threonine kinase activity
GO:0005024 IGI transforming growth factor beta-activated receptor activity
GO:0005026 IEA transforming growth factor beta receptor activity, type II
GO:0005515 IPI protein binding
GO:0005524 IEA ATP binding
GO:0005539 IEA glycosaminoglycan binding
GO:0005737 IEA cytoplasm
GO:0005829 IEA cytosol
GO:0005887 IEA integral component of plasma membrane
GO:0005901 ISO caveola
GO:0006468 TAS protein phosphorylation
GO:0006898 IEA receptor-mediated endocytosis
GO:0006915 IEA apoptotic process
GO:0007179 IMP transforming growth factor beta receptor signaling pathway
GO:0007182 IEA common-partner SMAD protein phosphorylation
GO:0007224 IMP smoothened signaling pathway
GO:0007369 IMP gastrulation
GO:0007420 IMP brain development
GO:0007507 IMP heart development
GO:0007566 IEA embryo implantation
GO:0007568 IEA aging
GO:0007584 IEA response to nutrient
GO:0008285 IEA negative regulation of cell proliferation
GO:0009612 IEA response to mechanical stimulus
GO:0009749 IEA response to glucose
GO:0009887 IEA organ morphogenesis
GO:0009897 IDA external side of plasma membrane
GO:0009986 IEA cell surface
GO:0010033 IEA response to organic substance
GO:0010468 IMP regulation of gene expression
GO:0010634 IMP positive regulation of epithelial cell migration
GO:0014070 IEA response to organic cyclic compound
GO:0018105 IEA peptidyl-serine phosphorylation
GO:0018107 IEA peptidyl-threonine phosphorylation
GO:0023014 IEA signal transduction by phosphorylation
GO:0030324 IMP lung development
GO:0031100 IEA organ regeneration
GO:0031435 IEA mitogen-activated protein kinase kinase kinase binding
GO:0032147 IDA activation of protein kinase activity
GO:0034713 IEA type I transforming growth factor beta receptor binding
GO:0034714 IEA type III transforming growth factor beta receptor binding
GO:0035162 IMP embryonic hemopoiesis
GO:0042060 IEA wound healing
GO:0042127 IMP regulation of cell proliferation
GO:0042493 IEA response to drug
GO:0043011 IMP myeloid dendritic cell differentiation
GO:0043415 IEA positive regulation of skeletal muscle tissue regeneration
GO:0043627 IEA response to estrogen
GO:0045121 ISO membrane raft
GO:0045766 IGI positive regulation of angiogenesis
GO:0046332 IDA SMAD binding
GO:0046872 IEA metal ion binding
GO:0048545 IEA response to steroid hormone
GO:0048565 IEA digestive tract development
GO:0048661 IEA positive regulation of smooth muscle cell proliferation
GO:0048701 IMP embryonic cranial skeleton morphogenesis
GO:0050431 IPI transforming growth factor beta binding
GO:0051138 IMP positive regulation of NK T cell differentiation
GO:0051216 IMP cartilage development
GO:0060021 IMP palate development
GO:0060044 IEA negative regulation of cardiac muscle cell proliferation
GO:0060389 IEA pathway-restricted SMAD protein phosphorylation
GO:0060425 IMP lung morphogenesis
GO:0060433 IMP bronchus development
GO:0060434 IMP bronchus morphogenesis
GO:0060439 IMP trachea morphogenesis
GO:0060440 IMP trachea formation
GO:0060443 IMP mammary gland morphogenesis
GO:0060463 IMP lung lobe morphogenesis
GO:0070723 IDA response to cholesterol
GO:1990086 IDA lens fiber cell apoptotic process
GO:2000379 IEA positive regulation of reactive oxygen species metabolic process

Homologs

ENSEMBL Accession Gene Name Biotype Species E-Value Bit Score
ENSDART00000039832 tgfbr2-001 protein_coding Danio_rerio 0 684
ENST00000295754 TGFBR2-001 protein_coding Homo_sapiens 0 1912
ENST00000359013 TGFBR2-002 protein_coding Homo_sapiens 0 2156

Loading