C-It-Loci: A knowledge database for tissue-enriched loci.

Institute of Cardiovascular Regeneration, Goethe-University Frankfurt am Main

Transcript Info
Description: platelet factor 4
Transcript Accession Transcript Name Contained in Gene Tax ID Strand Position Biotype
ENST00000296029 PF4-001 ENSG00000163737 9606 - 4:73981077-73982124 protein_coding

Homo sapiens EnsemblGRCh38

Genome
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Genes
Structures from Ensembl
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Transcripts
Structures from Ensembl
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Expression Patterns

Heat Map
Numeric Values
Transcript'; AdiposeAdrenalBrainBreastColonHeartKidneyLiverLungMuscleOvaryPlacentaTestisENST00000296029
Transcript ID Adipose Adrenal Brain Breast Colon Heart Kidney Liver Lung Muscle Ovary Placenta Testis
ENST00000296029 0.425±0.00 3.073±0.00 0.096±0.00 0.445±0.00 0.126±0.00 0.082±0.01 0.274±0.00 0.059±0.00 3.406±2.95 0.287±0.00 0.574±0.10 3.501±2.13 0.166±0.08

Conserved Regions

Gene is not located within a conserved region.

Gene Ontology

GO IDEvidence TypeGO Description
GO:0002576 TAS platelet degranulation
GO:0005576 IC:IEA extracellular region
GO:0005615 IEA extracellular space
GO:0006955 IEA immune response
GO:0007596 TAS blood coagulation
GO:0008009 TAS:IEA chemokine activity
GO:0008201 IDA heparin binding
GO:0010628 IDA positive regulation of gene expression
GO:0010744 IDA positive regulation of macrophage derived foam cell differentiation
GO:0016525 IDA negative regulation of angiogenesis
GO:0019221 IDA cytokine-mediated signaling pathway
GO:0030168 IDA platelet activation
GO:0030595 IDA leukocyte chemotaxis
GO:0030816 IDA positive regulation of cAMP metabolic process
GO:0031093 TAS platelet alpha granule lumen
GO:0032760 IDA positive regulation of tumor necrosis factor production
GO:0042127 IDA regulation of cell proliferation
GO:0043950 IDA positive regulation of cAMP-mediated signaling
GO:0045347 IDA negative regulation of MHC class II biosynthetic process
GO:0045651 IDA positive regulation of macrophage differentiation
GO:0045653 IDA negative regulation of megakaryocyte differentiation
GO:0045918 IDA negative regulation of cytolysis
GO:0045944 IDA positive regulation of transcription from RNA polymerase II promoter
GO:0048248 IDA CXCR3 chemokine receptor binding
GO:2001240 IDA negative regulation of extrinsic apoptotic signaling pathway in absence of ligand

Homologs

ENSEMBL Accession Gene Name Biotype Species E-Value Bit Score
ENSMUST00000031320 Pf4-201 protein_coding Mus_musculus 5.99756e-43 178

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