C-It-Loci: A knowledge database for tissue-enriched loci.

Institute of Cardiovascular Regeneration, Goethe-University Frankfurt am Main

Transcript Info
Description: nitric oxide synthase 3 (endothelial cell)
Transcript Accession Transcript Name Contained in Gene Tax ID Strand Position Biotype
ENST00000297494 NOS3-001 ENSG00000164867 9606 + 7:150990995-151014588 protein_coding

Expression Patterns

Heat Map
Numeric Values
Transcript'; AdiposeAdrenalBrainBreastColonHeartKidneyLiverLungMuscleOvaryPlacentaTestisENST00000297494
Transcript ID Adipose Adrenal Brain Breast Colon Heart Kidney Liver Lung Muscle Ovary Placenta Testis
ENST00000297494 6.180±0.00 3.001±0.00 1.182±0.00 0.411±0.00 1.002±0.94 2.073±0.00 1.179±0.99 1.300±0.00 3.436±0.00 0.822±0.30 3.139±1.96 4.161±2.21 2.314±0.00

Conserved Regions

Region IDSub-RegionRegion TypePosition
CIL_0008T1 CIL_0008T1_0001 VISTA 7:150668461-151272977
CIL_0004OG CIL_0004OG_0001 CGP 7:150944961-151014588
CIL_0004OH CIL_0004OH_0001 CGP 7:150990995-151024499

Gene Ontology

GO IDEvidence TypeGO Description
GO:0000139 TAS Golgi membrane
GO:0001525 IEA angiogenesis
GO:0001542 IEA ovulation from ovarian follicle
GO:0001701 IEA in utero embryonic development
GO:0001974 ISS blood vessel remodeling
GO:0002028 IEA regulation of sodium ion transport
GO:0003057 IEA regulation of the force of heart contraction by chemical signal
GO:0003100 IMP regulation of systemic arterial blood pressure by endothelin
GO:0003785 IPI actin monomer binding
GO:0003958 IBA NADPH-hemoprotein reductase activity
GO:0004517 IDA:IEA nitric-oxide synthase activity
GO:0005506 IEA iron ion binding
GO:0005515 IPI protein binding
GO:0005516 IEA calmodulin binding
GO:0005634 ISS nucleus
GO:0005737 IDA cytoplasm
GO:0005829 TAS cytosol
GO:0005856 IEA cytoskeleton
GO:0005886 TAS plasma membrane
GO:0005901 IDA caveola
GO:0006527 IDA arginine catabolic process
GO:0006809 IDA:IEA nitric oxide biosynthetic process
GO:0007005 ISS mitochondrion organization
GO:0007263 IBA nitric oxide mediated signal transduction
GO:0007596 TAS blood coagulation
GO:0008217 NAS regulation of blood pressure
GO:0008285 ISS negative regulation of cell proliferation
GO:0009408 NAS response to heat
GO:0010181 IEA:NAS FMN binding
GO:0010544 NAS negative regulation of platelet activation
GO:0014740 ISS negative regulation of muscle hyperplasia
GO:0014806 ISS smooth muscle hyperplasia
GO:0016491 IEA oxidoreductase activity
GO:0020037 IEA:IDA heme binding
GO:0030324 IEA lung development
GO:0030666 TAS endocytic vesicle membrane
GO:0031284 ISS positive regulation of guanylate cyclase activity
GO:0031663 IEA lipopolysaccharide-mediated signaling pathway
GO:0034405 IEP response to fluid shear stress
GO:0034617 IDA tetrahydrobiopterin binding
GO:0034618 IDA arginine binding
GO:0043267 IEA negative regulation of potassium ion transport
GO:0043542 IMP endothelial cell migration
GO:0044281 TAS small molecule metabolic process
GO:0045766 ISS positive regulation of angiogenesis
GO:0045776 IBA negative regulation of blood pressure
GO:0045909 NAS positive regulation of vasodilation
GO:0046209 TAS nitric oxide metabolic process
GO:0046870 NAS cadmium ion binding
GO:0050660 IEA:NAS flavin adenine dinucleotide binding
GO:0050661 IEA:NAS NADP binding
GO:0050880 ISS regulation of blood vessel size
GO:0050999 TAS regulation of nitric-oxide synthase activity
GO:0051346 IEA negative regulation of hydrolase activity
GO:0051701 TAS interaction with host
GO:0051926 IEA negative regulation of calcium ion transport
GO:0055114 IEA oxidation-reduction process
GO:0090382 TAS phagosome maturation
GO:1902042 ISS negative regulation of extrinsic apoptotic signaling pathway via death domain receptors

Homologs

ENSEMBL Accession Gene Name Biotype Species E-Value Bit Score
ENSMUST00000030834 Nos3-001 protein_coding Mus_musculus 0 4301
ENSMUST00000115090 Nos3-002 protein_coding Mus_musculus 0 3888

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