C-It-Loci: A knowledge database for tissue-enriched loci.

Institute of Cardiovascular Regeneration, Goethe-University Frankfurt am Main

Transcript Info
Description: Dab, mitogen-responsive phosphoprotein, homolog 2 (Drosophila)
Transcript Accession Transcript Name Contained in Gene Tax ID Strand Position Biotype
ENST00000320816 DAB2-001 ENSG00000153071 9606 - 5:39371678-39425170 protein_coding

Expression Patterns

Heat Map
Numeric Values
Transcript'; AdiposeAdrenalBladderBrainBreastColonHeartKidneyLiverLungMuscleOvaryPlacentaTestisENST00000320816
Transcript ID Adipose Adrenal Bladder Brain Breast Colon Heart Kidney Liver Lung Muscle Ovary Placenta Testis
ENST00000320816 49.759±0.00 14.522±0.00 12.939±0.00 1.310±0.91 10.449±7.25 9.691±3.21 3.520±0.97 20.253±0.00 10.602±0.00 11.918±2.09 1.451±0.05 13.350±4.74 44.575±6.23 8.089±7.11

Conserved Regions

Gene is not located within a conserved region.

Gene Ontology

GO IDEvidence TypeGO Description
GO:0000904 IEA cell morphogenesis involved in differentiation
GO:0001701 IEA in utero embryonic development
GO:0001921 IEA positive regulation of receptor recycling
GO:0001934 IMP positive regulation of protein phosphorylation
GO:0005178 IEA integrin binding
GO:0005515 IPI:IEA protein binding
GO:0005546 IEA phosphatidylinositol-4,5-bisphosphate binding
GO:0005634 IEA nucleus
GO:0005730 IDA nucleolus
GO:0005737 IEA cytoplasm
GO:0005765 TAS lysosomal membrane
GO:0005886 IDA plasma membrane
GO:0005905 IDA coated pit
GO:0005925 IDA focal adhesion
GO:0006898 IMP receptor-mediated endocytosis
GO:0006907 IEA pinocytosis
GO:0006915 IEA apoptotic process
GO:0007257 IEA activation of JUN kinase activity
GO:0007492 IEA endoderm development
GO:0007588 IEA excretion
GO:0008022 IPI protein C-terminus binding
GO:0008283 TAS cell proliferation
GO:0010718 IDA positive regulation of epithelial to mesenchymal transition
GO:0010862 IDA positive regulation of pathway-restricted SMAD protein phosphorylation
GO:0015031 IEA protein transport
GO:0016055 IEA Wnt signaling pathway
GO:0016324 IEA apical plasma membrane
GO:0030099 IEA myeloid cell differentiation
GO:0030132 IEA clathrin coat of coated pit
GO:0030136 IDA clathrin-coated vesicle
GO:0030276 IEA clathrin binding
GO:0030335 IMP positive regulation of cell migration
GO:0030511 IDA positive regulation of transforming growth factor beta receptor signaling pathway
GO:0032091 IMP negative regulation of protein binding
GO:0032436 IMP positive regulation of proteasomal ubiquitin-dependent protein catabolic process
GO:0032968 IEA positive regulation of transcription elongation from RNA polymerase II promoter
GO:0035026 IMP leading edge cell differentiation
GO:0035091 IEA phosphatidylinositol binding
GO:0035612 IEA AP-2 adaptor complex binding
GO:0035615 IMP clathrin adaptor activity
GO:0038024 IMP cargo receptor activity
GO:0043066 IDA negative regulation of apoptotic process
GO:0043231 IDA intracellular membrane-bounded organelle
GO:0045785 IEA positive regulation of cell adhesion
GO:0045807 IMP positive regulation of endocytosis
GO:0045892 IMP negative regulation of transcription, DNA-templated
GO:0045893 IMP positive regulation of transcription, DNA-templated
GO:0046332 IDA SMAD binding
GO:0048268 IEA clathrin coat assembly
GO:0060391 IDA positive regulation of SMAD protein import into nucleus
GO:0060766 IMP negative regulation of androgen receptor signaling pathway
GO:0061024 TAS membrane organization
GO:0070022 IDA transforming growth factor beta receptor homodimeric complex
GO:0070062 IDA extracellular vesicular exosome
GO:0071560 IEA cellular response to transforming growth factor beta stimulus
GO:0090090 IMP negative regulation of canonical Wnt signaling pathway
GO:1900026 IEA positive regulation of substrate adhesion-dependent cell spreading
GO:1903077 IMP negative regulation of protein localization to plasma membrane
GO:2000096 IMP positive regulation of Wnt signaling pathway, planar cell polarity pathway
GO:2000370 IMP positive regulation of clathrin-mediated endocytosis
GO:2000643 IMP positive regulation of early endosome to late endosome transport
GO:2001046 IEA positive regulation of integrin-mediated signaling pathway
GO:2001237 IEA negative regulation of extrinsic apoptotic signaling pathway

Homologs

ENSEMBL Accession Gene Name Biotype Species E-Value Bit Score
ENSMUST00000080880 Dab2-001 protein_coding Mus_musculus 0 2822
ENSMUST00000110664 Dab2-201 protein_coding Mus_musculus 0 1720
ENSMUST00000163082 Dab2-008 protein_coding Mus_musculus 0 1581
ENSMUST00000160134 Dab2-012 protein_coding Mus_musculus 0 966
ENSMUST00000110663 Dab2-006 protein_coding Mus_musculus 0 966
ENSMUST00000161040 Dab2-004 protein_coding Mus_musculus 0 885
ENSMUST00000078019 Dab2-003 protein_coding Mus_musculus 0 883
ENSMUST00000161812 Dab2-007 protein_coding Mus_musculus 0 859
ENSDART00000142271 BDP1 (1 of 2)-001 protein_coding Danio_rerio 0 235
ENSMUST00000161558 Dab2-013 retained_intron Mus_musculus 0 191

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