C-It-Loci: A knowledge database for tissue-enriched loci.

Institute of Cardiovascular Regeneration, Goethe-University Frankfurt am Main

Transcript Info
Description: purinergic receptor P2X, ligand-gated ion channel, 7
Transcript Accession Transcript Name Contained in Gene Tax ID Strand Position Biotype
ENST00000328963 P2RX7-008 ENSG00000089041 9606 + 12:121132828-121188032 protein_coding

Expression Patterns

Heat Map
Numeric Values
Transcript'; AdiposeBrainBreastColonOvaryPlacentaTestisENST00000328963
Transcript ID Adipose Brain Breast Colon Ovary Placenta Testis
ENST00000328963 0.816±0.00 3.982±2.11 0.501±0.00 0.645±0.00 1.334±0.83 1.009±0.23 0.673±0.02

Conserved Regions

Region IDSub-RegionRegion TypePosition
CIL_0002ZL CIL_0002ZL_0001 CGP 12:121132819-121234106

Gene Ontology

GO IDEvidence TypeGO Description
GO:0000187 IEA activation of MAPK activity
GO:0000287 IEA magnesium ion binding
GO:0000902 IEA cell morphogenesis
GO:0001530 ISS lipopolysaccharide binding
GO:0001614 IDA:IEA purinergic nucleotide receptor activity
GO:0001845 IEA phagolysosome assembly
GO:0001916 IEA positive regulation of T cell mediated cytotoxicity
GO:0001934 IEA positive regulation of protein phosphorylation
GO:0002028 ISS regulation of sodium ion transport
GO:0004872 IEA receptor activity
GO:0004931 IDA extracellular ATP-gated cation channel activity
GO:0005102 ISS receptor binding
GO:0005216 IEA ion channel activity
GO:0005507 IEA copper ion binding
GO:0005515 IEA protein binding
GO:0005524 IC:IEA ATP binding
GO:0005639 IBA integral component of nuclear inner membrane
GO:0005737 ISS cytoplasm
GO:0005886 ISS plasma membrane
GO:0005887 IC integral component of plasma membrane
GO:0005911 IEA cell-cell junction
GO:0006468 IEA protein phosphorylation
GO:0006509 IEA membrane protein ectodomain proteolysis
GO:0006649 IEA phospholipid transfer to membrane
GO:0006811 IEA ion transport
GO:0006812 IDA cation transport
GO:0006816 IEA calcium ion transport
GO:0006884 IEA cell volume homeostasis
GO:0006900 IEA membrane budding
GO:0006954 IEA inflammatory response
GO:0007005 IEA mitochondrion organization
GO:0007009 IEA plasma membrane organization
GO:0007166 ISS cell surface receptor signaling pathway
GO:0008270 IEA zinc ion binding
GO:0009612 IEA response to mechanical stimulus
GO:0009617 IEA response to bacterium
GO:0009897 IEA external side of plasma membrane
GO:0010033 IEA response to organic substance
GO:0010043 IEA response to zinc ion
GO:0010467 IEA gene expression
GO:0010524 IDA positive regulation of calcium ion transport into cytosol
GO:0012501 IEA programmed cell death
GO:0014049 IEA positive regulation of glutamate secretion
GO:0014054 IEA positive regulation of gamma-aminobutyric acid secretion
GO:0014070 IEA response to organic cyclic compound
GO:0015267 IEA channel activity
GO:0016020 IDA:IEA membrane
GO:0016079 IEA synaptic vesicle exocytosis
GO:0016485 IEA protein processing
GO:0019228 IEA neuronal action potential
GO:0019233 ISS sensory perception of pain
GO:0019835 IEA cytolysis
GO:0030501 ISS positive regulation of bone mineralization
GO:0031594 IEA neuromuscular junction
GO:0031668 IEA cellular response to extracellular stimulus
GO:0032059 ISS bleb
GO:0032060 ISS bleb assembly
GO:0032308 IEA positive regulation of prostaglandin secretion
GO:0032496 IEA response to lipopolysaccharide
GO:0032731 IEA positive regulation of interleukin-1 beta production
GO:0032755 IEA positive regulation of interleukin-6 production
GO:0032963 IEA collagen metabolic process
GO:0033198 IDA response to ATP
GO:0034405 IEA response to fluid shear stress
GO:0035590 IEA purinergic nucleotide receptor signaling pathway
GO:0035872 TAS nucleotide-binding domain, leucine rich repeat containing receptor signaling pathway
GO:0042098 IEA T cell proliferation
GO:0042493 IEA response to drug
GO:0042803 NAS protein homodimerization activity
GO:0043005 IEA neuron projection
GO:0043025 IEA neuronal cell body
GO:0043029 IEA T cell homeostasis
GO:0043065 IEA positive regulation of apoptotic process
GO:0043085 IEA positive regulation of catalytic activity
GO:0043132 IEA NAD transport
GO:0043195 IEA terminal bouton
GO:0043234 IEA protein complex
GO:0043409 ISS negative regulation of MAPK cascade
GO:0043410 IEA positive regulation of MAPK cascade
GO:0044254 IEA multicellular organismal protein catabolic process
GO:0045087 TAS innate immune response
GO:0045121 IEA membrane raft
GO:0045202 IEA synapse
GO:0045332 IEA phospholipid translocation
GO:0045778 IEA positive regulation of ossification
GO:0045779 ISS negative regulation of bone resorption
GO:0045919 ISS positive regulation of cytolysis
GO:0046513 IEA ceramide biosynthetic process
GO:0046931 IDA pore complex assembly
GO:0048705 IEA skeletal system morphogenesis
GO:0048873 IEA homeostasis of number of cells within a tissue
GO:0050714 IEA positive regulation of protein secretion
GO:0050715 IEA positive regulation of cytokine secretion
GO:0050717 IEA positive regulation of interleukin-1 alpha secretion
GO:0050718 IDA positive regulation of interleukin-1 beta secretion
GO:0050830 IEA defense response to Gram-positive bacterium
GO:0051209 IEA release of sequestered calcium ion into cytosol
GO:0051259 IEA protein oligomerization
GO:0051495 ISS positive regulation of cytoskeleton organization
GO:0051592 IEA response to calcium ion
GO:0051602 IEA response to electrical stimulus
GO:0051709 NAS regulation of killing of cells of other organism
GO:0051899 IDA membrane depolarization
GO:0051901 IEA positive regulation of mitochondrial depolarization
GO:0055085 IEA transmembrane transport
GO:0070230 IEA positive regulation of lymphocyte apoptotic process
GO:0072593 IEA reactive oxygen species metabolic process
GO:0097110 IEA scaffold protein binding
GO:0097190 ISS apoptotic signaling pathway
GO:0097191 IEA extrinsic apoptotic signaling pathway
GO:0098655 IDA cation transmembrane transport

Homologs

ENSEMBL Accession Gene Name Biotype Species E-Value Bit Score
ENSMUST00000100737 P2rx7-001 protein_coding Mus_musculus 0 1555
ENSMUST00000121489 P2rx7-002 protein_coding Mus_musculus 0 1153
ENSMUST00000031425 P2rx7-003 protein_coding Mus_musculus 0 1144
ENSMUST00000086247 P2rx7-004 protein_coding Mus_musculus 0 375

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