C-It-Loci: A knowledge database for tissue-enriched loci.

Institute of Cardiovascular Regeneration, Goethe-University Frankfurt am Main

Transcript Info
Description: transforming growth factor, beta receptor II (70/80kDa)
Transcript Accession Transcript Name Contained in Gene Tax ID Strand Position Biotype
ENST00000359013 TGFBR2-002 ENSG00000163513 9606 + 3:30606601-30694142 protein_coding

Expression Patterns

Heat Map
Numeric Values
Transcript'; AdiposeAdrenalBladderBrainBreastColonHeartKidneyLiverLungOvaryPlacentaTestisENST00000359013
Transcript ID Adipose Adrenal Bladder Brain Breast Colon Heart Kidney Liver Lung Ovary Placenta Testis
ENST00000359013 54.311±0.00 69.735±0.00 1.019±0.00 1.438±0.96 23.980±0.00 8.817±7.39 8.740±6.45 6.737±4.53 3.220±1.59 11.917±1.68 3.801±0.60 9.737±3.13 6.687±5.59

Conserved Regions

Gene is not located within a conserved region.

Gene Ontology

GO IDEvidence TypeGO Description
GO:0001568 TAS blood vessel development
GO:0001569 ISS patterning of blood vessels
GO:0001570 ISS vasculogenesis
GO:0001701 IEA in utero embryonic development
GO:0002053 ISS positive regulation of mesenchymal cell proliferation
GO:0002088 IEA lens development in camera-type eye
GO:0002651 ISS positive regulation of tolerance induction to self antigen
GO:0002663 ISS positive regulation of B cell tolerance induction
GO:0002666 ISS positive regulation of T cell tolerance induction
GO:0003417 IEA growth plate cartilage development
GO:0003430 IEA growth plate cartilage chondrocyte growth
GO:0004672 IEA protein kinase activity
GO:0004674 IEA protein serine/threonine kinase activity
GO:0004675 IDA transmembrane receptor protein serine/threonine kinase activity
GO:0004702 IEA receptor signaling protein serine/threonine kinase activity
GO:0004713 IEA protein tyrosine kinase activity
GO:0004872 IEA receptor activity
GO:0005024 IC transforming growth factor beta-activated receptor activity
GO:0005026 IEA transforming growth factor beta receptor activity, type II
GO:0005515 IPI protein binding
GO:0005524 IEA ATP binding
GO:0005539 IDA glycosaminoglycan binding
GO:0005737 IEA cytoplasm
GO:0005829 TAS cytosol
GO:0005886 TAS plasma membrane
GO:0005887 IEA integral component of plasma membrane
GO:0005901 IDA caveola
GO:0006468 IDA:IEA protein phosphorylation
GO:0006898 IEA receptor-mediated endocytosis
GO:0006915 IDA apoptotic process
GO:0007179 IMP:IEA transforming growth factor beta receptor signaling pathway
GO:0007182 IEA common-partner SMAD protein phosphorylation
GO:0007224 IEA smoothened signaling pathway
GO:0007369 IEA gastrulation
GO:0007420 ISS brain development
GO:0007507 ISS heart development
GO:0007566 IEA embryo implantation
GO:0007568 IEA aging
GO:0007584 IEA response to nutrient
GO:0008284 TAS positive regulation of cell proliferation
GO:0008285 IEA negative regulation of cell proliferation
GO:0009612 IEA response to mechanical stimulus
GO:0009749 IEA response to glucose
GO:0009887 IEA organ morphogenesis
GO:0009897 IDA external side of plasma membrane
GO:0009986 IEA cell surface
GO:0010033 IEA response to organic substance
GO:0010468 IEA regulation of gene expression
GO:0010634 IEA positive regulation of epithelial cell migration
GO:0014070 IEA response to organic cyclic compound
GO:0016020 IEA membrane
GO:0016021 IDA:IEA integral component of membrane
GO:0016772 IEA transferase activity, transferring phosphorus-containing groups
GO:0018105 IDA peptidyl-serine phosphorylation
GO:0018107 IDA peptidyl-threonine phosphorylation
GO:0023014 IEA signal transduction by phosphorylation
GO:0030324 IEA lung development
GO:0030512 TAS negative regulation of transforming growth factor beta receptor signaling pathway
GO:0031100 IEA organ regeneration
GO:0031435 IEA mitogen-activated protein kinase kinase kinase binding
GO:0032147 ISS activation of protein kinase activity
GO:0034713 IDA type I transforming growth factor beta receptor binding
GO:0034714 IDA type III transforming growth factor beta receptor binding
GO:0035162 ISS embryonic hemopoiesis
GO:0042060 IEA wound healing
GO:0042127 ISS regulation of cell proliferation
GO:0042493 IDA response to drug
GO:0043011 ISS myeloid dendritic cell differentiation
GO:0043235 IDA:IEA receptor complex
GO:0043415 IEA positive regulation of skeletal muscle tissue regeneration
GO:0043627 IEA response to estrogen
GO:0045121 IEA membrane raft
GO:0045766 IEA positive regulation of angiogenesis
GO:0046332 IDA SMAD binding
GO:0046872 IEA metal ion binding
GO:0048545 IEA response to steroid hormone
GO:0048565 IEA digestive tract development
GO:0048661 IEA positive regulation of smooth muscle cell proliferation
GO:0048701 ISS embryonic cranial skeleton morphogenesis
GO:0050431 IDA transforming growth factor beta binding
GO:0051138 ISS positive regulation of NK T cell differentiation
GO:0051216 IEA cartilage development
GO:0060021 ISS palate development
GO:0060044 IEA negative regulation of cardiac muscle cell proliferation
GO:0060389 IDA pathway-restricted SMAD protein phosphorylation
GO:0060425 IEA lung morphogenesis
GO:0060433 IEA bronchus development
GO:0060434 IEA bronchus morphogenesis
GO:0060439 IEA trachea morphogenesis
GO:0060440 IEA trachea formation
GO:0060443 IEA mammary gland morphogenesis
GO:0060463 IEA lung lobe morphogenesis
GO:0070022 IC transforming growth factor beta receptor homodimeric complex
GO:0070723 IDA response to cholesterol
GO:1990086 IEA lens fiber cell apoptotic process
GO:2000379 IMP positive regulation of reactive oxygen species metabolic process

Homologs

ENSEMBL Accession Gene Name Biotype Species E-Value Bit Score
ENSMUST00000061101 Tgfbr2-202 protein_coding Mus_musculus 0 2156
ENSMUST00000035014 Tgfbr2-201 protein_coding Mus_musculus 0 1912

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