C-It-Loci: A knowledge database for tissue-enriched loci.

Institute of Cardiovascular Regeneration, Goethe-University Frankfurt am Main

Transcript Info
Description: myeloid cell leukemia 1
Transcript Accession Transcript Name Contained in Gene Tax ID Strand Position Biotype
ENST00000369026 MCL1-001 ENSG00000143384 9606 - 1:150574556-150579590 protein_coding

Expression Patterns

Heat Map
Numeric Values
Transcript'; AdiposeAdrenalBladderBrainBreastColonHeartKidneyLiverLungMuscleOvaryPlacentaTestisENST00000369026
Transcript ID Adipose Adrenal Bladder Brain Breast Colon Heart Kidney Liver Lung Muscle Ovary Placenta Testis
ENST00000369026 77.815±0.00 58.734±0.00 9.478±0.00 16.083±8.09 63.222±9.02 47.096±28.16 28.411±19.10 39.095±20.77 27.857±4.31 73.868±38.69 30.185±25.20 75.525±48.29 65.730±26.03 31.844±12.25

Conserved Regions

Gene is not located within a conserved region.

Gene Ontology

GO IDEvidence TypeGO Description
GO:0001709 NAS cell fate determination
GO:0005515 IPI protein binding
GO:0005634 IDA nucleus
GO:0005737 TAS cytoplasm
GO:0005739 IDA mitochondrion
GO:0005741 IBA mitochondrial outer membrane
GO:0005759 IEA mitochondrial matrix
GO:0005829 ISS cytosol
GO:0007275 IEA multicellular organismal development
GO:0008630 IBA intrinsic apoptotic signaling pathway in response to DNA damage
GO:0008637 IEA apoptotic mitochondrial changes
GO:0015266 TAS protein channel activity
GO:0016020 ISS membrane
GO:0016021 IEA integral component of membrane
GO:0019725 NAS cellular homeostasis
GO:0034097 IDA response to cytokine
GO:0042803 IBA protein homodimerization activity
GO:0042981 IEA regulation of apoptotic process
GO:0043066 IEA negative regulation of apoptotic process
GO:0046982 IPI protein heterodimerization activity
GO:0051434 IPI BH3 domain binding
GO:0071806 TAS protein transmembrane transport
GO:0097136 IDA Bcl-2 family protein complex
GO:0097192 IMP extrinsic apoptotic signaling pathway in absence of ligand
GO:1903378 IGI positive regulation of oxidative stress-induced neuron intrinsic apoptotic signaling pathway
GO:2000811 IMP negative regulation of anoikis
GO:2001020 IMP regulation of response to DNA damage stimulus
GO:2001240 IMP negative regulation of extrinsic apoptotic signaling pathway in absence of ligand
GO:2001243 IBA negative regulation of intrinsic apoptotic signaling pathway

Homologs

ENSEMBL Accession Gene Name Biotype Species E-Value Bit Score
ENSMUST00000037947 Mcl1-201 protein_coding Mus_musculus 0 830
ENSMUST00000178686 Mcl1-202 protein_coding Mus_musculus 0 743
ENSMUST00000173716 Gm20432-001 processed_pseudogene Mus_musculus 0 291

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