C-It-Loci: A knowledge database for tissue-enriched loci.

Institute of Cardiovascular Regeneration, Goethe-University Frankfurt am Main

Gene Info

Description: myeloid cell leukemia 1
Gene AccessionGene NameTax IDStrandPositionGene Biotype
ENSG00000143384 MCL1 9606 - 1:150574551-150579738 protein_coding
  Transcript Accession Transcript Name Position Transcript Biotype
  ENST00000307940 MCL1-002 150577070-150579530 protein_coding
  ENST00000369026 MCL1-001 150574556-150579590 protein_coding
  ENST00000464132 MCL1-003 150576927-150578777 processed_transcript
  ENST00000620947 MCL1-201 150574551-150579738 protein_coding

Expression Patterns

Heat Map
Numeric Values
Transcript'; AdiposeAdrenalBladderBrainBreastColonHeartKidneyLiverLungMuscleOvaryPlacentaTestisENST00000307940ENST00000369026ENST00000464132ENST00000620947
Transcript ID Adipose Adrenal Bladder Brain Breast Colon Heart Kidney Liver Lung Muscle Ovary Placenta Testis
ENST00000307940 N/A N/A N/A N/A N/A N/A N/A N/A 18.927±0.00 N/A 15.035±0.00 N/A N/A N/A
ENST00000369026 77.815±0.00 58.734±0.00 9.478±0.00 16.083±8.09 63.222±9.02 47.096±28.16 28.411±19.10 39.095±20.77 27.857±4.31 73.868±38.69 30.185±25.20 75.525±48.29 65.730±26.03 31.844±12.25
ENST00000464132 N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A 18.930±0.00
ENST00000620947 N/A N/A 2.699±0.00 2.071±0.00 18.229±0.00 8.971±0.00 2.504±0.00 5.451±0.00 7.749±0.00 14.663±0.00 7.362±0.00 28.325±18.36 18.709±0.00 12.014±0.00

Conserved Regions

Gene is not located within a conserved region.

Gene Ontology
GO IDEvidence TypeGO Description
GO:0001709 NAS cell fate determination
GO:0005515 IPI protein binding
GO:0005634 IDA nucleus
GO:0005737 TAS cytoplasm
GO:0005739 IDA mitochondrion
GO:0005741 IBA mitochondrial outer membrane
GO:0005759 IEA mitochondrial matrix
GO:0005829 ISS cytosol
GO:0007275 IEA multicellular organismal development
GO:0008630 IBA intrinsic apoptotic signaling pathway in response to DNA damage
GO:0008637 IEA apoptotic mitochondrial changes
GO:0015266 TAS protein channel activity
GO:0016020 ISS membrane
GO:0016021 IEA integral component of membrane
GO:0019725 NAS cellular homeostasis
GO:0034097 IDA response to cytokine
GO:0042803 IBA protein homodimerization activity
GO:0042981 IEA regulation of apoptotic process
GO:0043066 IEA negative regulation of apoptotic process
GO:0046982 IPI protein heterodimerization activity
GO:0051434 IPI BH3 domain binding
GO:0071806 TAS protein transmembrane transport
GO:0097136 IDA Bcl-2 family protein complex
GO:0097192 IMP extrinsic apoptotic signaling pathway in absence of ligand
GO:1903378 IGI positive regulation of oxidative stress-induced neuron intrinsic apoptotic signaling pathway
GO:2000811 IMP negative regulation of anoikis
GO:2001020 IMP regulation of response to DNA damage stimulus
GO:2001240 IMP negative regulation of extrinsic apoptotic signaling pathway in absence of ligand
GO:2001243 IBA negative regulation of intrinsic apoptotic signaling pathway

Homologs

ENSEMBL Accession Gene Name Description Biotype Species
ENSDARG00000008363 mcl1b myeloid cell leukemia sequence 1b protein_coding Danio_rerio
ENSDARG00000009779 mcl1a myeloid cell leukemia sequence 1a protein_coding Danio_rerio
ENSMUSG00000038612 Mcl1 myeloid cell leukemia sequence 1 protein_coding Mus_musculus

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