C-It-Loci: A knowledge database for tissue-enriched loci.

Institute of Cardiovascular Regeneration, Goethe-University Frankfurt am Main

Transcript Info
Description: v-akt murine thymoma viral oncogene homolog 1
Transcript Accession Transcript Name Contained in Gene Tax ID Strand Position Biotype
ENST00000407796 AKT1-002 ENSG00000142208 9606 - 14:104769349-104795679 protein_coding

Expression Patterns

Heat Map
Numeric Values
Transcript'; AdiposeAdrenalBrainBreastColonHeartKidneyLiverLungMuscleOvaryPlacentaTestisENST00000407796
Transcript ID Adipose Adrenal Brain Breast Colon Heart Kidney Liver Lung Muscle Ovary Placenta Testis
ENST00000407796 51.456±0.00 73.760±0.00 6.740±1.76 28.263±24.28 35.160±29.35 29.160±26.62 26.385±18.43 25.860±18.82 14.897±12.33 17.090±14.89 42.239±25.38 27.184±10.04 26.552±0.00

Conserved Regions

Region IDSub-RegionRegion TypePosition
CIL_0001G0 CIL_0001G0_0001 CGP 14:104753100-104795751
CIL_00030T CIL_00030T_0001 CGP 14:104769349-104804712

Gene Ontology

GO IDEvidence TypeGO Description
GO:0000060 IMP protein import into nucleus, translocation
GO:0001934 IDA positive regulation of protein phosphorylation
GO:0001938 IMP positive regulation of endothelial cell proliferation
GO:0004672 TAS:IEA protein kinase activity
GO:0004674 IDA:IEA protein serine/threonine kinase activity
GO:0004712 IDA protein serine/threonine/tyrosine kinase activity
GO:0004713 IEA protein tyrosine kinase activity
GO:0005515 IPI protein binding
GO:0005524 IC:IEA ATP binding
GO:0005547 IDA phosphatidylinositol-3,4,5-trisphosphate binding
GO:0005634 IDA nucleus
GO:0005654 TAS nucleoplasm
GO:0005737 ISS cytoplasm
GO:0005829 IDA cytosol
GO:0005886 IDA plasma membrane
GO:0005979 IMP regulation of glycogen biosynthetic process
GO:0006417 IEA regulation of translation
GO:0006464 TAS cellular protein modification process
GO:0006468 IDA:IEA protein phosphorylation
GO:0006469 ISS negative regulation of protein kinase activity
GO:0006809 TAS nitric oxide biosynthetic process
GO:0006915 TAS apoptotic process
GO:0006924 IMP activation-induced cell death of T cells
GO:0006979 ISS response to oxidative stress
GO:0007165 TAS signal transduction
GO:0007173 TAS epidermal growth factor receptor signaling pathway
GO:0007186 TAS G-protein coupled receptor signaling pathway
GO:0007596 TAS blood coagulation
GO:0008283 TAS cell proliferation
GO:0008286 IMP insulin receptor signaling pathway
GO:0008543 TAS fibroblast growth factor receptor signaling pathway
GO:0009408 TAS response to heat
GO:0010467 TAS gene expression
GO:0010507 IMP negative regulation of autophagy
GO:0010748 IMP negative regulation of plasma membrane long-chain fatty acid transport
GO:0010907 IMP positive regulation of glucose metabolic process
GO:0010951 IMP negative regulation of endopeptidase activity
GO:0010975 ISS regulation of neuron projection development
GO:0015630 IDA microtubule cytoskeleton
GO:0016070 TAS RNA metabolic process
GO:0016071 TAS mRNA metabolic process
GO:0016301 IDA kinase activity
GO:0016310 IDA phosphorylation
GO:0016772 IEA transferase activity, transferring phosphorus-containing groups
GO:0018105 IDA peptidyl-serine phosphorylation
GO:0019899 ISS enzyme binding
GO:0030154 TAS cell differentiation
GO:0030168 TAS platelet activation
GO:0030235 IMP nitric-oxide synthase regulator activity
GO:0030307 IDA positive regulation of cell growth
GO:0030334 IMP regulation of cell migration
GO:0031018 TAS endocrine pancreas development
GO:0031295 TAS T cell costimulation
GO:0031659 IDA positive regulation of cyclin-dependent protein serine/threonine kinase activity involved in G1/S transition of mitotic cell cycle
GO:0031999 IMP negative regulation of fatty acid beta-oxidation
GO:0032270 ISS positive regulation of cellular protein metabolic process
GO:0032869 ISS cellular response to insulin stimulus
GO:0033138 IDA positive regulation of peptidyl-serine phosphorylation
GO:0034405 IMP response to fluid shear stress
GO:0035556 IDA intracellular signal transduction
GO:0038095 TAS Fc-epsilon receptor signaling pathway
GO:0042802 IPI identical protein binding
GO:0043066 IDA negative regulation of apoptotic process
GO:0043154 ISS negative regulation of cysteine-type endopeptidase activity involved in apoptotic process
GO:0043325 IDA phosphatidylinositol-3,4-bisphosphate binding
GO:0043536 IDA positive regulation of blood vessel endothelial cell migration
GO:0044281 TAS small molecule metabolic process
GO:0045087 TAS innate immune response
GO:0045429 IMP positive regulation of nitric oxide biosynthetic process
GO:0045600 IMP positive regulation of fat cell differentiation
GO:0045725 IMP positive regulation of glycogen biosynthetic process
GO:0045861 IMP negative regulation of proteolysis
GO:0046209 TAS nitric oxide metabolic process
GO:0046326 IMP positive regulation of glucose import
GO:0046777 TAS protein autophosphorylation
GO:0046889 IMP positive regulation of lipid biosynthetic process
GO:0048009 IMP insulin-like growth factor receptor signaling pathway
GO:0048011 TAS neurotrophin TRK receptor signaling pathway
GO:0048015 TAS phosphatidylinositol-mediated signaling
GO:0050999 TAS regulation of nitric-oxide synthase activity
GO:0051000 IMP positive regulation of nitric-oxide synthase activity
GO:0051091 IDA positive regulation of sequence-specific DNA binding transcription factor activity
GO:0060644 TAS mammary gland epithelial cell differentiation
GO:0061024 TAS membrane organization
GO:0070141 IDA response to UV-A
GO:0071889 IPI 14-3-3 protein binding
GO:0090004 IMP positive regulation of establishment of protein localization to plasma membrane
GO:0090201 ISS negative regulation of release of cytochrome c from mitochondria
GO:0097193 TAS intrinsic apoptotic signaling pathway
GO:1900740 TAS positive regulation of protein insertion into mitochondrial membrane involved in apoptotic signaling pathway
GO:1901215 NAS negative regulation of neuron death
GO:1901976 TAS regulation of cell cycle checkpoint
GO:1902176 NAS negative regulation of oxidative stress-induced intrinsic apoptotic signaling pathway
GO:2001240 TAS negative regulation of extrinsic apoptotic signaling pathway in absence of ligand

Homologs

ENSEMBL Accession Gene Name Biotype Species E-Value Bit Score
ENSMUST00000001780 Akt1-001 protein_coding Mus_musculus 0 2069
ENSMUST00000128300 Akt1-006 protein_coding Mus_musculus 0 1109
ENSMUST00000123563 Akt1-008 retained_intron Mus_musculus 0 857
ENSMUST00000144550 Akt1-002 protein_coding Mus_musculus 0 789
ENSMUST00000130342 Akt1-003 protein_coding Mus_musculus 0 505
ENSMUST00000127588 Akt1-007 retained_intron Mus_musculus 0 392
ENSMUST00000159815 Akt1-009 retained_intron Mus_musculus 0 377
ENSMUST00000139388 Akt1-004 processed_transcript Mus_musculus 0 315
ENSMUST00000127902 Akt1-005 processed_transcript Mus_musculus 1.4013e-45 189

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