C-It-Loci: A knowledge database for tissue-enriched loci.

Institute of Cardiovascular Regeneration, Goethe-University Frankfurt am Main

Transcript Info
Description: ring finger and FYVE-like domain containing E3 ubiquitin protein ligase
Transcript Accession Transcript Name Contained in Gene Tax ID Strand Position Biotype
ENST00000413582 RFFL-003 ENSG00000092871 9606 - 17:35011909-35042297 protein_coding

Expression Patterns

No expression data.

Conserved Regions

Region IDSub-RegionRegion TypePosition
CIL_00055Q CIL_00055Q_0001 CGP 17:34961530-35009743
CIL_00055O CIL_00055O_0001 CGP 17:34980494-35089319

Gene Ontology

GO IDEvidence TypeGO Description
GO:0002020 IPI protease binding
GO:0002039 IPI p53 binding
GO:0002947 IDA tumor necrosis factor receptor superfamily complex
GO:0005515 IPI:IEA protein binding
GO:0005737 IDA cytoplasm
GO:0005886 IDA plasma membrane
GO:0006511 IDA ubiquitin-dependent protein catabolic process
GO:0008270 IEA zinc ion binding
GO:0010008 IDA endosome membrane
GO:0010762 ISS regulation of fibroblast migration
GO:0010804 IMP negative regulation of tumor necrosis factor-mediated signaling pathway
GO:0016020 IDA membrane
GO:0016874 IEA ligase activity
GO:0019901 IPI protein kinase binding
GO:0031625 IPI ubiquitin protein ligase binding
GO:0032006 IC regulation of TOR signaling
GO:0042787 IMP protein ubiquitination involved in ubiquitin-dependent protein catabolic process
GO:0043161 IMP proteasome-mediated ubiquitin-dependent protein catabolic process
GO:0061630 IDA ubiquitin protein ligase activity
GO:0070936 IDA protein K48-linked ubiquitination
GO:1901797 IMP negative regulation of signal transduction by p53 class mediator
GO:1902042 IMP negative regulation of extrinsic apoptotic signaling pathway via death domain receptors
GO:2001271 IMP negative regulation of cysteine-type endopeptidase activity involved in execution phase of apoptosis

Homologs

ENSEMBL Accession Gene Name Biotype Species E-Value Bit Score
ENSMUST00000074515 Rffl-001 protein_coding Mus_musculus 0 1395
ENSMUST00000071152 Rffl-201 protein_coding Mus_musculus 0 1308
ENSMUST00000108173 Rffl-203 protein_coding Mus_musculus 0 1308
ENSMUST00000093975 Rffl-202 protein_coding Mus_musculus 0 1303
ENSMUST00000103218 Rffl-002 protein_coding Mus_musculus 0 811
ENSMUST00000021036 Rffl-003 protein_coding Mus_musculus 0 811
ENSMUST00000126660 Rffl-004 protein_coding Mus_musculus 0 433
ENSDART00000065132 protein_coding Danio_rerio 2e-36 158

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