C-It-Loci: A knowledge database for tissue-enriched loci.

Institute of Cardiovascular Regeneration, Goethe-University Frankfurt am Main

Transcript Info
Description: mitogen-activated protein kinase kinase 4
Transcript Accession Transcript Name Contained in Gene Tax ID Strand Position Biotype
ENST00000415385 MAP2K4-002 ENSG00000065559 9606 + 17:12020834-12143830 protein_coding

Expression Patterns

Heat Map
Numeric Values
Transcript'; AdrenalBrainHeartENST00000415385
Transcript ID Adrenal Brain Heart
ENST00000415385 1.076±0.00 4.019±0.00 0.771±0.00

Conserved Regions

Region IDSub-RegionRegion TypePosition
CIL_0008WK CIL_0008WK_0001 VISTA 17:11924684-12528146

Gene Ontology

GO IDEvidence TypeGO Description
GO:0000165 IEA MAPK cascade
GO:0001934 IEA positive regulation of protein phosphorylation
GO:0002224 TAS toll-like receptor signaling pathway
GO:0002755 TAS MyD88-dependent toll-like receptor signaling pathway
GO:0002756 TAS MyD88-independent toll-like receptor signaling pathway
GO:0004672 TAS:IEA protein kinase activity
GO:0004674 IEA protein serine/threonine kinase activity
GO:0004708 IEA MAP kinase kinase activity
GO:0004713 IEA protein tyrosine kinase activity
GO:0005515 IPI protein binding
GO:0005524 IEA ATP binding
GO:0005634 IEA nucleus
GO:0005829 TAS cytosol
GO:0006468 IEA protein phosphorylation
GO:0006915 IEA apoptotic process
GO:0007165 TAS signal transduction
GO:0007254 TAS JNK cascade
GO:0007257 IEA activation of JUN kinase activity
GO:0008545 IEA JUN kinase kinase activity
GO:0016772 IEA transferase activity, transferring phosphorus-containing groups
GO:0018108 IEA peptidyl-tyrosine phosphorylation
GO:0030424 IEA axon
GO:0031435 IEA mitogen-activated protein kinase kinase kinase binding
GO:0032839 IEA dendrite cytoplasm
GO:0034134 TAS toll-like receptor 2 signaling pathway
GO:0034138 TAS toll-like receptor 3 signaling pathway
GO:0034142 TAS toll-like receptor 4 signaling pathway
GO:0034146 TAS toll-like receptor 5 signaling pathway
GO:0034162 TAS toll-like receptor 9 signaling pathway
GO:0034166 TAS toll-like receptor 10 signaling pathway
GO:0035666 TAS TRIF-dependent toll-like receptor signaling pathway
GO:0038095 TAS Fc-epsilon receptor signaling pathway
GO:0038123 TAS toll-like receptor TLR1:TLR2 signaling pathway
GO:0038124 TAS toll-like receptor TLR6:TLR2 signaling pathway
GO:0043065 IEA positive regulation of apoptotic process
GO:0043204 IEA perikaryon
GO:0043525 IEA positive regulation of neuron apoptotic process
GO:0045087 TAS innate immune response
GO:0045740 IEA positive regulation of DNA replication
GO:0051403 TAS stress-activated MAPK cascade
GO:0051770 IEA positive regulation of nitric-oxide synthase biosynthetic process
GO:0061049 IEA cell growth involved in cardiac muscle cell development
GO:0071260 IEP cellular response to mechanical stimulus
GO:0072709 IEA cellular response to sorbitol

Homologs

ENSEMBL Accession Gene Name Biotype Species E-Value Bit Score
ENSMUST00000046963 Map2k4-005 protein_coding Mus_musculus 0 2662
ENSMUST00000152096 Map2k4-003 protein_coding Mus_musculus 0 1027
ENSMUST00000125598 Map2k4-007 protein_coding Mus_musculus 0 813
ENSMUST00000140301 Map2k4-001 nonsense_mediated_decay Mus_musculus 0 809
ENSDART00000130761 map2k4a-001 protein_coding Danio_rerio 0 684
ENSDART00000093037 map2k4a-003 protein_coding Danio_rerio 0 676
ENSDART00000058834 map2k4a-002 protein_coding Danio_rerio 0 592
ENSMUST00000140740 Map2k4-006 processed_transcript Mus_musculus 0 449
ENSMUST00000138093 Map2k4-004 processed_transcript Mus_musculus 0 427
ENSMUST00000130009 Map2k4-002 nonsense_mediated_decay Mus_musculus 0 385

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