C-It-Loci: A knowledge database for tissue-enriched loci.

Institute of Cardiovascular Regeneration, Goethe-University Frankfurt am Main

Transcript Info
Description: Janus kinase 3
Transcript Accession Transcript Name Contained in Gene Tax ID Strand Position Biotype
ENST00000458235 JAK3-201 ENSG00000105639 9606 - 19:17824786-17848032 protein_coding

Expression Patterns

Heat Map
Numeric Values
Transcript'; AdiposeAdrenalBrainBreastColonHeartKidneyLiverLungMuscleOvaryPlacentaTestisENST00000458235
Transcript ID Adipose Adrenal Brain Breast Colon Heart Kidney Liver Lung Muscle Ovary Placenta Testis
ENST00000458235 5.759±0.00 12.517±0.00 0.436±0.00 1.499±0.00 0.697±0.12 0.417±0.36 0.729±0.00 0.565±0.00 4.521±3.18 0.267±0.00 3.287±2.94 2.606±0.33 3.151±0.00

Conserved Regions

Gene is not located within a conserved region.

Gene Ontology

GO IDEvidence TypeGO Description
GO:0002731 ISS negative regulation of dendritic cell cytokine production
GO:0004672 IEA protein kinase activity
GO:0004713 ISS:IEA protein tyrosine kinase activity
GO:0004715 IEA non-membrane spanning protein tyrosine kinase activity
GO:0005515 IPI protein binding
GO:0005524 IEA ATP binding
GO:0005829 TAS cytosol
GO:0005856 IEA cytoskeleton
GO:0006468 TAS:IEA protein phosphorylation
GO:0007167 ISS enzyme linked receptor protein signaling pathway
GO:0007260 TAS tyrosine phosphorylation of STAT protein
GO:0007262 TAS STAT protein import into nucleus
GO:0016020 IEA membrane
GO:0016772 IEA transferase activity, transferring phosphorus-containing groups
GO:0018108 ISS peptidyl-tyrosine phosphorylation
GO:0019221 IEA cytokine-mediated signaling pathway
GO:0019903 IPI protein phosphatase binding
GO:0030183 ISS B cell differentiation
GO:0032693 ISS negative regulation of interleukin-10 production
GO:0032695 ISS negative regulation of interleukin-12 production
GO:0035556 ISS:IEA intracellular signal transduction
GO:0035771 IDA interleukin-4-mediated signaling pathway
GO:0043029 ISS T cell homeostasis
GO:0045087 IEA innate immune response
GO:0045221 ISS negative regulation of FasL biosynthetic process
GO:0045626 ISS negative regulation of T-helper 1 cell differentiation
GO:0045944 IEA positive regulation of transcription from RNA polymerase II promoter
GO:0050868 ISS negative regulation of T cell activation
GO:0060397 TAS JAK-STAT cascade involved in growth hormone signaling pathway
GO:0070232 ISS regulation of T cell apoptotic process
GO:0070244 ISS negative regulation of thymocyte apoptotic process
GO:0070669 TAS response to interleukin-2
GO:0070670 IDA response to interleukin-4
GO:0070672 TAS response to interleukin-15
GO:0071104 TAS response to interleukin-9
GO:2000670 IEA positive regulation of dendritic cell apoptotic process
GO:2001241 IEA positive regulation of extrinsic apoptotic signaling pathway in absence of ligand

Homologs

ENSEMBL Accession Gene Name Biotype Species E-Value Bit Score
ENSMUST00000110012 Jak3-005 protein_coding Mus_musculus 0 2551
ENSMUST00000051995 Jak3-001 protein_coding Mus_musculus 0 2549
ENSMUST00000110013 Jak3-004 protein_coding Mus_musculus 0 2549
ENSMUST00000130624 Jak3-003 retained_intron Mus_musculus 0 1679
ENSMUST00000133263 Jak3-002 retained_intron Mus_musculus 0 510
ENSMUST00000117445 Spata22-002 protein_coding Mus_musculus 0.000000000000006 88

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