C-It-Loci: A knowledge database for tissue-enriched loci.

Institute of Cardiovascular Regeneration, Goethe-University Frankfurt am Main

Transcript Info
Description: checkpoint kinase 1
Transcript Accession Transcript Name Contained in Gene Tax ID Strand Position Biotype
ENST00000544373 CHEK1-005 ENSG00000149554 9606 + 11:125625977-125655710 protein_coding

Expression Patterns

No expression data.

Conserved Regions

Gene is not located within a conserved region.

Gene Ontology

GO IDEvidence TypeGO Description
GO:0000077 IDA DNA damage checkpoint
GO:0000781 IDA chromosome, telomeric region
GO:0000785 ISS chromatin
GO:0000794 IDA condensed nuclear chromosome
GO:0004672 IEA protein kinase activity
GO:0004674 IDA protein serine/threonine kinase activity
GO:0005515 IPI protein binding
GO:0005524 IEA ATP binding
GO:0005615 IDA extracellular space
GO:0005634 IDA nucleus
GO:0005654 TAS nucleoplasm
GO:0005813 IDA centrosome
GO:0005829 TAS cytosol
GO:0006260 TAS DNA replication
GO:0006281 IMP DNA repair
GO:0006468 IEA protein phosphorylation
GO:0006974 IMP cellular response to DNA damage stimulus
GO:0006975 IDA DNA damage induced protein phosphorylation
GO:0010569 IDA regulation of double-strand break repair via homologous recombination
GO:0010767 ISS regulation of transcription from RNA polymerase II promoter in response to UV-induced DNA damage
GO:0016772 IEA transferase activity, transferring phosphorus-containing groups
GO:0018107 IDA peptidyl-threonine phosphorylation
GO:0031572 IMP G2 DNA damage checkpoint
GO:0035402 IDA histone kinase activity (H3-T11 specific)
GO:0043231 IDA intracellular membrane-bounded organelle
GO:0045839 IDA negative regulation of mitosis
GO:0046602 IDA regulation of mitotic centrosome separation
GO:0048096 ISS chromatin-mediated maintenance of transcription
GO:0071260 IEP cellular response to mechanical stimulus
GO:0090399 NAS replicative senescence
GO:2000615 ISS regulation of histone H3-K9 acetylation

Homologs

ENSEMBL Accession Gene Name Biotype Species E-Value Bit Score
ENSMUST00000174105 Chek1-004 nonsense_mediated_decay Mus_musculus 0 1676
ENSMUST00000034625 Chek1-201 protein_coding Mus_musculus 0 1565
ENSMUST00000172702 Chek1-002 protein_coding Mus_musculus 0 1565
ENSMUST00000173963 Chek1-005 protein_coding Mus_musculus 0 1142
ENSMUST00000173534 Chek1-006 protein_coding Mus_musculus 0 952
ENSMUST00000174794 Chek1-010 retained_intron Mus_musculus 0 798

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