C-It-Loci: A knowledge database for tissue-enriched loci.

Institute of Cardiovascular Regeneration, Goethe-University Frankfurt am Main

Gene Info

Description: checkpoint kinase 1
Gene AccessionGene NameTax IDStrandPositionGene Biotype
ENSG00000149554 CHEK1 9606 + 11:125625136-125676255 protein_coding
  Transcript Accession Transcript Name Position Transcript Biotype
  ENST00000278916 CHEK1-006 125626749-125655713 protein_coding
  ENST00000427383 CHEK1-001 125625726-125655476 protein_coding
  ENST00000428830 CHEK1-002 125625974-125676255 protein_coding
  ENST00000438015 CHEK1-201 125625136-125657145 protein_coding
  ENST00000498122 CHEK1-016 125644572-125676255 nonsense_mediated_decay
  ENST00000524737 CHEK1-007 125626558-125656335 protein_coding
  ENST00000525396 CHEK1-018 125625665-125629437 nonsense_mediated_decay
  ENST00000526937 CHEK1-010 125626005-125633250 protein_coding
  ENST00000527013 CHEK1-011 125626002-125633351 protein_coding
  ENST00000528276 CHEK1-015 125642861-125655586 retained_intron
  ENST00000531062 CHEK1-014 125633287-125636135 retained_intron
  ENST00000531607 CHEK1-012 125626749-125633193 protein_coding
  ENST00000532449 CHEK1-202 125625136-125657145 protein_coding
  ENST00000532669 CHEK1-013 125625993-125637544 protein_coding
  ENST00000533778 CHEK1-009 125626229-125627668 protein_coding
  ENST00000534070 CHEK1-004 125626341-125657147 protein_coding
  ENST00000534685 CHEK1-008 125626007-125629417 protein_coding
  ENST00000544373 CHEK1-005 125625977-125655710 protein_coding

Expression Patterns

No expression data.

Conserved Regions

Gene is not located within a conserved region.

Gene Ontology
GO IDEvidence TypeGO Description
GO:0000077 IDA DNA damage checkpoint
GO:0000086 IEA G2/M transition of mitotic cell cycle
GO:0000781 IDA chromosome, telomeric region
GO:0000785 ISS chromatin
GO:0000794 IDA condensed nuclear chromosome
GO:0004672 IEA protein kinase activity
GO:0004674 IEA protein serine/threonine kinase activity
GO:0004713 IEA protein tyrosine kinase activity
GO:0005515 IPI protein binding
GO:0005524 IEA ATP binding
GO:0005615 IDA extracellular space
GO:0005634 IDA nucleus
GO:0005654 TAS nucleoplasm
GO:0005657 IEA replication fork
GO:0005813 IDA centrosome
GO:0005829 TAS cytosol
GO:0006260 TAS DNA replication
GO:0006281 IMP DNA repair
GO:0006468 IEA protein phosphorylation
GO:0006974 IMP cellular response to DNA damage stimulus
GO:0006975 IDA DNA damage induced protein phosphorylation
GO:0010468 IEA regulation of gene expression
GO:0010569 IDA regulation of double-strand break repair via homologous recombination
GO:0010767 ISS regulation of transcription from RNA polymerase II promoter in response to UV-induced DNA damage
GO:0010972 IEA negative regulation of G2/M transition of mitotic cell cycle
GO:0016772 IEA transferase activity, transferring phosphorus-containing groups
GO:0018107 IDA peptidyl-threonine phosphorylation
GO:0031572 IMP G2 DNA damage checkpoint
GO:0035402 IDA histone kinase activity (H3-T11 specific)
GO:0035407 IEA histone H3-T11 phosphorylation
GO:0042127 IEA regulation of cell proliferation
GO:0043231 IDA intracellular membrane-bounded organelle
GO:0045839 IDA negative regulation of mitosis
GO:0046602 IDA regulation of mitotic centrosome separation
GO:0048096 ISS chromatin-mediated maintenance of transcription
GO:0071260 IEP cellular response to mechanical stimulus
GO:0071310 IEA cellular response to organic substance
GO:0071313 IEA cellular response to caffeine
GO:0090399 NAS replicative senescence
GO:2000279 IEA negative regulation of DNA biosynthetic process
GO:2000615 ISS regulation of histone H3-K9 acetylation

Homologs

ENSEMBL Accession Gene Name Description Biotype Species
ENSDARG00000014385 chek1 CHK1 checkpoint homolog (S. pombe) protein_coding Danio_rerio
ENSMUSG00000032113 Chek1 checkpoint kinase 1 protein_coding Mus_musculus

Loading